POMP and DCPH1

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		POMP	DCPH1
Description		proteasome maturation protein	damage control phosphatase 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Membrane Nuclear Speck
	Molecular Function	Protein Binding	Protein Binding Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Protein-glutamate O-methyltransferase Activity Transferase Activity Hydrolase Activity Phosphatase Activity Enzyme Binding Metal Ion Binding Protein Carboxyl O-methyltransferase Activity Fructose 6-phosphate Aldolase Activity Fructose-1-phosphatase Activity
	Biological Process	Proteasome Assembly	DNA Damage Response Methylation
Pathways		Proteasome assembly Proteasome assembly
Drugs
Diseases		Keratosis linearis with ichthyosis congenita and sclerosing keratoderma; KLICK syndrome
GWAS		Breast cancer (menopausal hormone therapy interaction) ( 24080446) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Red blood cell count ( 32888494) Refractive error ( 32231278)
Interacting Genes		24 interacting genes: ATXN1 CAPN3 DCPH1 ECT2 FAM107A GPD1 GRB2 KCNA10 KIF1B KLHL41 MPPED2 PSMA3 PSMB1 PSMB10 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PYGM RBM5 SSR4 TTN VCL	3 interacting genes: HSPB1 POMP PPP3CA
Entrez ID		51371	79624
HPRD ID		12613	09854
Ensembl ID		ENSG00000132963	ENSG00000146476
Uniprot IDs		Q9Y244	B4DPT6 F5GZY1 Q9H993
PDB IDs		8QYJ 8QYL 8QYM 8QYN 8QYS 8QZ9 8TM4 8TM5 8TM6 8YIX 8YIY	6UMQ 6UMR
Enriched GO Terms of Interacting Partners?		Proteasome Core Complex Proteasome Core Complex, Beta-subunit Complex Threonine-type Endopeptidase Activity Proteasome Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Endopeptidase Activity Protein Catabolic Process Proteasomal Protein Catabolic Process Spermatoproteasome Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Peptidase Activity Proteolysis Catabolic Process Extracellular Exosome Myofibril Assembly Cytosol Cytoplasm Hydrolase Activity Actomyosin Structure Organization M Band Secretory Granule Lumen Ficolin-1-rich Granule Lumen Response To Calcium Ion Insulin-like Growth Factor Receptor Signaling Pathway Calcium-dependent Self Proteolysis Protein-containing Complex Assembly Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Glycerol-3-phosphate Dehydrogenase (NAD+) Activity Guanyl-nucleotide Exchange Factor Adaptor Activity Inner Dense Plaque Of Desmosome Podosome Ring Outer Dense Plaque Of Desmosome Protein Carboxyl O-methyltransferase Activity Protein-glutamate O-methyltransferase Activity Fructose 6-phosphate Aldolase Activity Actin Cytoskeleton Organization Sarcomere Organization Structural Constituent Of Muscle Myofibril Actin Filament-based Process Ligase Regulator Activity Positive Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Protein-containing Complex Organization Cell-cell Junction Glycerol-3-phosphate Dehydrogenase [NAD(P)+] Activity Glycerol-3-phosphate Catabolic Process Glycerol-3-phosphate Shuttle	Regulation Of Protein Kinase C Signaling Positive Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of Gene Expression Protein Transport Along Microtubule Regulation Of Multicellular Organismal Development Negative Regulation Of Protein Kinase C Signaling Positive Regulation Of Developmental Process Anterograde Axonal Protein Transport Protein Kinase C Inhibitor Activity Contractile Muscle Fiber Z Disc Negative Regulation Of Calcium Ion Import Across Plasma Membrane Negative Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Synaptic Vesicle Exocytosis Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Leukocyte Differentiation Regulation Of T Cell Activation Calcineurin Complex Positive Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Kidney Development Positive Regulation Of Saliva Secretion Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Dendrite Morphogenesis Positive Regulation Of Connective Tissue Replacement Positive Regulation Of Glomerulus Development Positive Regulation Of Calcium Ion Import Across Plasma Membrane Transition Between Fast And Slow Fiber Regulation Of Cell Proliferation Involved In Kidney Morphogenesis Regulation Of Skeletal Muscle Adaptation Regulation Of Connective Tissue Replacement Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Protein Serine/threonine Phosphatase Complex Negative Regulation Of Calcium Ion Import Positive Regulation Of T Cell Activation Regulation Of Calcium Ion Import Across Plasma Membrane Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Digestive System Process Peptidyl-serine Dephosphorylation Extrinsic Component Of Plasma Membrane Calmodulin-dependent Protein Phosphatase Activity Regulation Of Saliva Secretion Proteasome Assembly BBAF Complex Brahma Complex
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