POMP and KLHL41

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		POMP	KLHL41
Description		proteasome maturation protein	kelch like family member 41
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Membrane Nuclear Speck	Ruffle Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Membrane Sarcoplasmic Reticulum Pseudopodium M Band Cul3-RING Ubiquitin Ligase Complex Sarcoplasmic Reticulum Membrane Cell Projection
	Molecular Function	Protein Binding	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Proteasome Assembly	Striated Muscle Contraction Protein Ubiquitination Myofibril Assembly Skeletal Muscle Cell Differentiation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Myoblast Differentiation Regulation Of Myoblast Proliferation Regulation Of Skeletal Muscle Cell Differentiation
Pathways		Proteasome assembly Proteasome assembly	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Keratosis linearis with ichthyosis congenita and sclerosing keratoderma; KLICK syndrome
GWAS		Breast cancer (menopausal hormone therapy interaction) ( 24080446) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Red blood cell count ( 32888494) Refractive error ( 32231278)
Interacting Genes		24 interacting genes: ATXN1 CAPN3 DCPH1 ECT2 FAM107A GPD1 GRB2 KCNA10 KIF1B KLHL41 MPPED2 PSMA3 PSMB1 PSMB10 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PYGM RBM5 SSR4 TTN VCL	9 interacting genes: IFRD1 MYBPC1 NRAP POMP RBM4 RCHY1 SLC2A4 SPMIP2 TCAP
Entrez ID		51371	10324
HPRD ID		12613	07610
Ensembl ID		ENSG00000132963	ENSG00000239474
Uniprot IDs		Q9Y244	O60662
PDB IDs		8QYJ 8QYL 8QYM 8QYN 8QYS 8QZ9 8TM4 8TM5 8TM6 8YIX 8YIY
Enriched GO Terms of Interacting Partners?		Proteasome Core Complex Proteasome Core Complex, Beta-subunit Complex Threonine-type Endopeptidase Activity Proteasome Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Endopeptidase Activity Protein Catabolic Process Proteasomal Protein Catabolic Process Spermatoproteasome Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Peptidase Activity Proteolysis Catabolic Process Extracellular Exosome Myofibril Assembly Cytosol Cytoplasm Hydrolase Activity Actomyosin Structure Organization M Band Secretory Granule Lumen Ficolin-1-rich Granule Lumen Response To Calcium Ion Insulin-like Growth Factor Receptor Signaling Pathway Calcium-dependent Self Proteolysis Protein-containing Complex Assembly Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Glycerol-3-phosphate Dehydrogenase (NAD+) Activity Guanyl-nucleotide Exchange Factor Adaptor Activity Inner Dense Plaque Of Desmosome Podosome Ring Outer Dense Plaque Of Desmosome Protein Carboxyl O-methyltransferase Activity Protein-glutamate O-methyltransferase Activity Fructose 6-phosphate Aldolase Activity Actin Cytoskeleton Organization Sarcomere Organization Structural Constituent Of Muscle Myofibril Actin Filament-based Process Ligase Regulator Activity Positive Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Protein-containing Complex Organization Cell-cell Junction Glycerol-3-phosphate Dehydrogenase [NAD(P)+] Activity Glycerol-3-phosphate Catabolic Process Glycerol-3-phosphate Shuttle	Titin Binding
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