MS4A13 and TMEM74

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MS4A13	TMEM74
Description		membrane spanning 4-domains A13	transmembrane protein 74
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Autophagosome Membrane Lysosome Lysosomal Membrane Plasma Membrane Membrane Cytoplasmic Vesicle
	Molecular Function	Protein Binding	Protein Binding Transmembrane Transporter Binding
	Biological Process	Cell Surface Receptor Signaling Pathway	Autophagy Macroautophagy General Adaptation Syndrome, Behavioral Process
Pathways
Drugs
Diseases
GWAS		Congenital heart disease (maternal effect) ( 28468790) Major depressive disorder ( 29317602) Metabolite levels (X-11787) ( 23934736)	Male-pattern baldness ( 27182965)
Interacting Genes		63 interacting genes: AQP2 AQP6 ASGR2 ATP6V0E1 BEST1 BIK CBARP CD79A CLDN7 CREB3L1 CREB3L3 DAGLA EBP EDA EREG ERGIC3 EVA1A FAM209A FAM210B FFAR2 GJA4 GJA5 GJA8 GJB1 GJB5 GJB6 GJC3 GPR152 GPR42 HERPUD2 JSRP1 KCNMB4 KLRC1 LHFPL5 LRRC3B MMGT1 MS4A3 NPDC1 ODF4 POMK RAMP1 RHCG RNF185 SCN3B SLC10A6 SLC12A7 SLC13A4 SLC16A2 SLC18A1 SLC30A2 SLC39A2 SLC7A1 SPAG4 SSMEM1 TBXA2R TLCD4 TM4SF18 TMC4 TMEM14B TMEM237 TMEM52B TMEM74 VSIR	7 interacting genes: AQP6 FATE1 LIME1 LMNA MS4A13 SPCS1 TMEM42
Entrez ID		503497	157753
HPRD ID		17604	08702
Ensembl ID		ENSG00000204979	ENSG00000164841
Uniprot IDs		Q5J8X5	Q96NL1
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Transmembrane Transport Connexin Complex Gap Junction Channel Activity Gap Junction Plasma Membrane Monoatomic Ion Transport Protein Binding Inorganic Ion Transmembrane Transport Gap Junction Assembly Cell-cell Signaling Inorganic Cation Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Signaling Cell Communication Metal Ion Transport Cell Communication By Electrical Coupling Inorganic Anion Transmembrane Transport Gap Junction Channel Activity Involved In AV Node Cell-bundle Of His Cell Electrical Coupling AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling Cell-cell Junction Assembly Anchoring Junction Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Inorganic Anion Transport SA Node Cell Action Potential Gap Junction-mediated Intercellular Transport AV Node Cell To Bundle Of His Cell Communication Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Renal Water Transport Endoplasmic Reticulum Membrane Channel Activity Monoatomic Cation Transmembrane Transport Ammonium Channel Activity Chloride Transmembrane Transport Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Transmembrane Transporter Activity Cell-cell Junction Organization Ammonium Transmembrane Transport Intercellular Transport Chloride Transport System Process Amine Transport Transport Vesicle Membrane Water Channel Activity Monoatomic Anion Transmembrane Transport Carbon Dioxide Transport Cell Communication By Electrical Coupling Involved In Cardiac Conduction	PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Lamin Filament Nuclear Pore Localization Signal Peptidase Complex B Cell Receptor Complex Negative Regulation Of Mitochondrial Calcium Ion Concentration Monoatomic Anion Channel Activity Renal Water Transport Negative Regulation Of Mesenchymal Cell Proliferation Virion Assembly Ammonium Channel Activity Signal Peptide Processing Ammonium Transmembrane Transport Ventricular Cardiac Muscle Cell Development
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