MS4A13 and EDA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MS4A13	EDA
Description		membrane spanning 4-domains A13	ectodysplasin A
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Extracellular Region Collagen Trimer Extracellular Space Endoplasmic Reticulum Membrane Lipid Droplet Cytoskeleton Plasma Membrane Membrane Apical Part Of Cell
	Molecular Function	Protein Binding	Signaling Receptor Binding Death Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Death Receptor Agonist Activity
	Biological Process	Cell Surface Receptor Signaling Pathway	Hair Follicle Development Immune Response Cell-matrix Adhesion Cell Surface Receptor Signaling Pathway Gene Expression Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Cell Differentiation Odontogenesis Of Dentin-containing Tooth Odontogenesis Positive Regulation Of Canonical NF-kappaB Signal Transduction Pigmentation Skin Development Canonical Wnt Signaling Pathway Salivary Gland Cavitation Hair Follicle Placode Formation Trachea Gland Development Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways			TNFs bind their physiological receptors
Drugs
Diseases			Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidrotic Tooth agenesis; Hypodontia
GWAS		Congenital heart disease (maternal effect) ( 28468790) Major depressive disorder ( 29317602) Metabolite levels (X-11787) ( 23934736)	Male-pattern baldness ( 30573740) Metabolite levels ( 23823483) Monobrow ( 27182965) Primary tooth development (number of teeth) ( 20195514 23704328) Primary tooth development (time to first tooth eruption) ( 20195514 23704328) Tooth agenesis (maxillary lateral incisors) ( 29364747)
Interacting Genes		63 interacting genes: AQP2 AQP6 ASGR2 ATP6V0E1 BEST1 BIK CBARP CD79A CLDN7 CREB3L1 CREB3L3 DAGLA EBP EDA EREG ERGIC3 EVA1A FAM209A FAM210B FFAR2 GJA4 GJA5 GJA8 GJB1 GJB5 GJB6 GJC3 GPR152 GPR42 HERPUD2 JSRP1 KCNMB4 KLRC1 LHFPL5 LRRC3B MMGT1 MS4A3 NPDC1 ODF4 POMK RAMP1 RHCG RNF185 SCN3B SLC10A6 SLC12A7 SLC13A4 SLC16A2 SLC18A1 SLC30A2 SLC39A2 SLC7A1 SPAG4 SSMEM1 TBXA2R TLCD4 TM4SF18 TMC4 TMEM14B TMEM237 TMEM52B TMEM74 VSIR	23 interacting genes: ATP6V0C CTXN3 CYB561 DOLK EDA2R EDAR EMP1 EMP3 FURIN GIMAP5 LEPROTL1 LPAR3 MAL MS4A13 OSTC OSTCP1 PLN PMP22 SEC22A SLC38A7 TMEM42 TMEM50B TMEM60
Entrez ID		503497	1896
HPRD ID		17604	02347
Ensembl ID		ENSG00000204979	ENSG00000158813
Uniprot IDs		Q5J8X5	A0A0U5J797 Q92838
PDB IDs			1RJ7 1RJ8 7X9G
Enriched GO Terms of Interacting Partners?		Membrane Transmembrane Transport Connexin Complex Gap Junction Channel Activity Gap Junction Plasma Membrane Monoatomic Ion Transport Protein Binding Inorganic Ion Transmembrane Transport Gap Junction Assembly Cell-cell Signaling Inorganic Cation Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Signaling Cell Communication Metal Ion Transport Cell Communication By Electrical Coupling Inorganic Anion Transmembrane Transport Gap Junction Channel Activity Involved In AV Node Cell-bundle Of His Cell Electrical Coupling AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling Cell-cell Junction Assembly Anchoring Junction Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Inorganic Anion Transport SA Node Cell Action Potential Gap Junction-mediated Intercellular Transport AV Node Cell To Bundle Of His Cell Communication Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Renal Water Transport Endoplasmic Reticulum Membrane Channel Activity Monoatomic Cation Transmembrane Transport Ammonium Channel Activity Chloride Transmembrane Transport Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Transmembrane Transporter Activity Cell-cell Junction Organization Ammonium Transmembrane Transport Intercellular Transport Chloride Transport System Process Amine Transport Transport Vesicle Membrane Water Channel Activity Monoatomic Anion Transmembrane Transport Carbon Dioxide Transport Cell Communication By Electrical Coupling Involved In Cardiac Conduction	Bleb Assembly Membrane Lysosomal Membrane Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Endosome Transport Via Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Epidermis Development Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Dolichol Kinase Activity L-asparagine:sodium Symporter Activity L-glutamine:sodium Symporter Activity
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