MS4A13 and KCNMB4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MS4A13	KCNMB4
Description		membrane spanning 4-domains A13	potassium calcium-activated channel subfamily M regulatory beta subunit 4
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Synapse
	Molecular Function	Protein Binding	Protein Binding Calcium-activated Potassium Channel Activity Potassium Channel Regulator Activity Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential
	Biological Process	Cell Surface Receptor Signaling Pathway	Action Potential Detection Of Calcium Ion Monoatomic Ion Transport Potassium Ion Transport Chemical Synaptic Transmission Neuronal Action Potential Regulation Of Vasoconstriction Monoatomic Ion Transmembrane Transport Regulation Of Neurotransmitter Secretion Potassium Ion Transmembrane Transport Regulation Of Presynaptic Membrane Potential
Pathways			Ca2+ activated K+ channels cGMP effects
Drugs			Procaine Ritodrine Nitrendipine Miconazole Colforsin Trimebutine
Diseases
GWAS		Congenital heart disease (maternal effect) ( 28468790) Major depressive disorder ( 29317602) Metabolite levels (X-11787) ( 23934736)	Appendicular lean mass ( 33097823) Gut microbiota relative abundance (unassigned genus belonging to family Clostridiales) ( 33208821) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Metabolite levels ( 23823483)
Interacting Genes		63 interacting genes: AQP2 AQP6 ASGR2 ATP6V0E1 BEST1 BIK CBARP CD79A CLDN7 CREB3L1 CREB3L3 DAGLA EBP EDA EREG ERGIC3 EVA1A FAM209A FAM210B FFAR2 GJA4 GJA5 GJA8 GJB1 GJB5 GJB6 GJC3 GPR152 GPR42 HERPUD2 JSRP1 KCNMB4 KLRC1 LHFPL5 LRRC3B MMGT1 MS4A3 NPDC1 ODF4 POMK RAMP1 RHCG RNF185 SCN3B SLC10A6 SLC12A7 SLC13A4 SLC16A2 SLC18A1 SLC30A2 SLC39A2 SLC7A1 SPAG4 SSMEM1 TBXA2R TLCD4 TM4SF18 TMC4 TMEM14B TMEM237 TMEM52B TMEM74 VSIR	3 interacting genes: MAL MS4A13 SNCA
Entrez ID		503497	27345
HPRD ID		17604	05564
Ensembl ID		ENSG00000204979	ENSG00000135643
Uniprot IDs		Q5J8X5	Q86W47
PDB IDs			5Y7L 6V22 6V35 9CZH 9CZJ 9CZK 9CZM 9CZO 9CZQ 9D18 9D19
Enriched GO Terms of Interacting Partners?		Membrane Transmembrane Transport Connexin Complex Gap Junction Channel Activity Gap Junction Plasma Membrane Monoatomic Ion Transport Protein Binding Inorganic Ion Transmembrane Transport Gap Junction Assembly Cell-cell Signaling Inorganic Cation Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Signaling Cell Communication Metal Ion Transport Cell Communication By Electrical Coupling Inorganic Anion Transmembrane Transport Gap Junction Channel Activity Involved In AV Node Cell-bundle Of His Cell Electrical Coupling AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling Cell-cell Junction Assembly Anchoring Junction Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Inorganic Anion Transport SA Node Cell Action Potential Gap Junction-mediated Intercellular Transport AV Node Cell To Bundle Of His Cell Communication Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Renal Water Transport Endoplasmic Reticulum Membrane Channel Activity Monoatomic Cation Transmembrane Transport Ammonium Channel Activity Chloride Transmembrane Transport Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Transmembrane Transporter Activity Cell-cell Junction Organization Ammonium Transmembrane Transport Intercellular Transport Chloride Transport System Process Amine Transport Transport Vesicle Membrane Water Channel Activity Monoatomic Anion Transmembrane Transport Carbon Dioxide Transport Cell Communication By Electrical Coupling Involved In Cardiac Conduction	Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Protein Localization To Paranode Region Of Axon Membrane Raft Polarization Peptidase Activator Activity Involved In Apoptotic Process Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Negative Regulation Of Chaperone-mediated Autophagy Regulation Of Serotonin Uptake MCRD-mediated MRNA Stability Complex RISC Complex Binding Dopamine Uptake Involved In Synaptic Transmission Nuclear-transcribed MRNA Catabolic Process, No-go Decay CRD-mediated MRNA Stability Complex Membrane Raft Distribution Response To Iron(II) Ion Membrane Raft Localization Regulation Of Chaperone-mediated Autophagy Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Oxidative Phosphorylation Protein Localization To Axon Schmidt-Lanterman Incisure Structural Constituent Of Myelin Sheath Mitochondrial ATP Synthesis Coupled Electron Transport Cuprous Ion Binding Catecholamine Uptake Dopamine Uptake Dopamine Biosynthetic Process Regulation Of Acyl-CoA Biosynthetic Process Positive Regulation Of Inositol Phosphate Biosynthetic Process Negative Regulation Of Cellular Respiration Supramolecular Fiber IRES-dependent Viral Translational Initiation CRD-mediated MRNA Stabilization Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors SNARE Complex Assembly Cellular Response To Epinephrine Stimulus Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Lipid Binding
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