VIPR2 and ADCYAP1

Number of citations of the paper that reports this interaction (PMID 8146174)
17

Data Source:
HPRD (in vitro, in vivo)

		VIPR2	ADCYAP1
Gene Name		vasoactive intestinal peptide receptor 2	adenylate cyclase activating polypeptide 1 (pituitary)
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Extracellular Space Terminal Bouton
	Molecular Function	G-protein Coupled Receptor Activity Vasoactive Intestinal Polypeptide Receptor Activity	Receptor Signaling Protein Activity Receptor Binding Neuropeptide Hormone Activity Pituitary Adenylate Cyclase Activating Polypeptide Activity Pituitary Adenylate Cyclase-activating Polypeptide Receptor Binding Peptide Hormone Receptor Binding
	Biological Process	Signal Transduction G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Cell-cell Signaling Negative Regulation Of Smooth Muscle Cell Proliferation	Ovarian Follicle Development Behavioral Fear Response Histamine Secretion Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Negative Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Cell-cell Signaling Female Pregnancy Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Cell Proliferation Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Sensory Perception Of Pain CAMP-mediated Signaling Pituitary Gland Development Neuron Projection Development Positive Regulation Of Interleukin-6 Production Positive Regulation Of Rap GTPase Activity Regulation Of Protein Localization Negative Regulation Of Rho GTPase Activity Response To Starvation Negative Regulation Of Potassium Ion Transport Response To Ethanol Negative Regulation Of Cell Cycle Positive Regulation Of Protein Kinase Activity Positive Regulation Of Vasodilation Positive Regulation Of Transcription From RNA Polymerase II Promoter ATP Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Positive Regulation Of Growth Hormone Secretion Negative Regulation Of Glial Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Somatostatin Secretion
Pathways		Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Signalling by NGF G alpha (s) signalling events Activation of TRKA receptors Glucagon-type ligand receptors NGF signalling via TRKA from the plasma membrane GPCR ligand binding Metabolic disorders of biological oxidation enzymes GPCR downstream signaling NGF-independant TRKA activation Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Myopia (pathological) ( 23406873)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		4 interactors: ADCYAP1 APP ERBB2IP VIP	8 interactors: ADCYAP1R1 CASP2 CPAMD8 MME SCTR SHH VIPR1 VIPR2
Entrez ID		7434	116
HPRD ID		03576	02369
Ensembl ID		ENSG00000106018	ENSG00000141433
Uniprot IDs		P41587 Q6ZN22	P18509
PDB IDs		2X57	1GEA 2D2P 2JOD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Potassium Ion Transport Positive Regulation Of Vasodilation Positive Regulation Of Adenylate Cyclase Activity Regulation Of Vasodilation Positive Regulation Of Lyase Activity Single-organism Behavior Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Regulation Of Potassium Ion Transport Positive Regulation Of CAMP Biosynthetic Process Regulation Of Cyclase Activity Positive Regulation Of CAMP Metabolic Process Behavior Positive Regulation Of Cyclic Nucleotide Metabolic Process Secretion Regulation Of CAMP Biosynthetic Process Negative Regulation Of Ion Transport Regulation Of CAMP Metabolic Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Somatostatin Secretion Negative Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Growth Cell Surface Receptor Signaling Pathway Basal Protein Localization Synaptic Growth At Neuromuscular Junction Neurological System Process Collateral Sprouting In Absence Of Injury Positive Regulation Of Protein Metabolic Process Learning Or Memory Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Negative Regulation Of Neurogenesis Cognition Cellular Calcium Ion Homeostasis Prolactin Secretion Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Phosphorus Metabolic Process Calcium Ion Homeostasis Positive Regulation Of Catalytic Activity Axon Choice Point Recognition Negative Regulation Of Cell Development Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Penile Erection Positive Regulation Of Growth Hormone Secretion Neuron Remodeling Negative Regulation Of Transport	Activation Of Adenylate Cyclase Activity Protein Processing Positive Regulation Of Adenylate Cyclase Activity Sex Differentiation Positive Regulation Of Lyase Activity Cell Surface Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Positive Regulation Of CAMP Biosynthetic Process Regulation Of Cyclase Activity Positive Regulation Of CAMP Metabolic Process G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cyclic Nucleotide Metabolic Process Negative Regulation Of Ureter Smooth Muscle Cell Differentiation Positive Regulation Of Ureter Smooth Muscle Cell Differentiation Positive Regulation Of Sclerotome Development Multicellular Structure Septum Development Negative Regulation Of Kidney Smooth Muscle Cell Differentiation Positive Regulation Of Kidney Smooth Muscle Cell Differentiation Positive Regulation Of Skeletal Muscle Cell Proliferation Regulation Of Mesenchymal Cell Proliferation Involved In Prostate Gland Development Mesenchymal Smoothened Signaling Pathway Involved In Prostate Gland Development Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Development Of Primary Female Sexual Characteristics Epithelial-mesenchymal Signaling Involved In Prostate Gland Development Right Lung Development Primary Prostatic Bud Elongation Intein-mediated Protein Splicing Polarity Specification Of Anterior/posterior Axis Digestion Cellular Response To Stimulus Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Left Lung Development Cellular Response To UV-A Regulation Of Proteolysis Cerebellar Granule Cell Precursor Proliferation Developmental Process Involved In Reproduction Hormone Metabolic Process Positive Regulation Of Immature T Cell Proliferation In Thymus Cell Proliferation In Hindbrain Positive Regulation Of Smooth Muscle Cell Differentiation Prostate Epithelial Cord Elongation Specification Of Axis Polarity Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Positive Regulation Of Hh Target Transcription Factor Activity Negative Regulation Of Cholesterol Efflux Luteolysis Creatinine Metabolic Process Positive Regulation Of Immature T Cell Proliferation
Tagcloud ?		7q36 7qter affymetrix arise asymptomatic boy condensin delay deletion deletions dysmorphism encompassing esyt2 father grandfather harbored heterozygosity inherited mcph1 microcephaly mother ncapg2 novo paternal prenatal psychomotor retardation snp wdr60
Tagcloud (Difference) ?		7q36 7qter affymetrix arise asymptomatic boy condensin delay deletion deletions dysmorphism encompassing esyt2 father grandfather harbored heterozygosity inherited mcph1 microcephaly mother ncapg2 novo paternal prenatal psychomotor retardation snp wdr60
Tagcloud (Intersection) ?