VBP1 and PFDN2

Number of citations of the paper that reports this interaction (PubMedID 31839598)
57

Data Source:
BioGRID (cross-linking study, cross-linking study)
HPRD (in vitro)

		VBP1	PFDN2
Description		VHL binding protein 1	prefoldin subunit 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Prefoldin Complex Protein-containing Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Prefoldin Complex Protein-containing Complex Protein Folding Chaperone Complex RPAP3/R2TP/prefoldin-like Complex
	Molecular Function	Amyloid-beta Binding Protein Binding Tubulin Binding Unfolded Protein Binding	Amyloid-beta Binding Protein Binding Protein Folding Chaperone Unfolded Protein Binding
	Biological Process	Protein Folding Microtubule-based Process Tubulin Complex Assembly Negative Regulation Of Amyloid Fibril Formation	Protein Folding Protein Stabilization Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Amyloid Fibril Formation
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC	Prefoldin mediated transfer of substrate to CCT/TriC
Drugs
Diseases
GWAS
Interacting Genes		31 interacting genes: AIRIM DDIT4L EFHC1 ENKD1 FGF1 GLIS2 GPANK1 HIF1A IKZF3 LMO1 LMO2 LMO3 MEOX2 MISP MKNK2 MSH4 MYOZ1 PFDN2 PIK3R3 PNMA1 PRKAB2 SUOX TCEANC TSC22D4 UBC UBL7 VEZF1 VHL XRCC6 ZNF410 ZNF576	10 interacting genes: CEBPA DBI ERBB3 MAP3K3 PFDN1 PFDN4 PKNOX1 UBASH3A VBP1 ZNF726
Entrez ID		7411	5202
HPRD ID		02135	09658
Ensembl ID		ENSG00000155959	ENSG00000143256
Uniprot IDs		P61758 Q6FH24	B1AQP2 Q9UHV9
PDB IDs		6NR8 6NR9 6NRB 6NRC 6NRD 7WU7	6NR8 6NR9 6NRB 6NRC 6NRD 7WU7
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Gene Expression Positive Regulation Of Phosphate Metabolic Process Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT	Prefoldin Complex Negative Regulation Of Amyloid Fibril Formation Regulation Of Amyloid Fibril Formation Amyloid-beta Binding Unfolded Protein Binding Protein-containing Complex Regulation Of Supramolecular Fiber Organization Negative Regulation Of Supramolecular Fiber Organization Protein Folding Negative Regulation Of Protein Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process Response To Vitamin B2 C/EBP Complex Protein-lipid Complex Negative Regulation Of Protein Lipidation Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Negative Regulation Of Glycine Import Across Plasma Membrane Regulation Of Protein Metabolic Process CHOP-C/EBP Complex Regulation Of Metabolic Process Neuregulin Receptor Activity Negative Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process White Fat Cell Proliferation Benzodiazepine Receptor Binding Long-chain Fatty Acyl-CoA Binding Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Negative Regulation Of Lipoprotein Metabolic Process ErbB-3 Class Receptor Binding Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Dorsal Root Ganglion Development
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