CIDEA and UCP1

Number of citations of the paper that reports this interaction (PMID 12910269)
74

Data Source:
HPRD (in vitro)

		CIDEA	UCP1
Gene Name		cell death-inducing DFFA-like effector a	uncoupling protein 1 (mitochondrial, proton carrier)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Envelope Lipid Particle	Mitochondrion Mitochondrial Inner Membrane Integral Component Of Membrane
	Molecular Function	Protein Homodimerization Activity	Oxidative Phosphorylation Uncoupler Activity
	Biological Process	Temperature Homeostasis Transcription, DNA-templated Regulation Of Transcription, DNA-templated Lipid Metabolic Process Apoptotic Process Cell Death Positive Regulation Of Sequestering Of Triglyceride Lipid Storage Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Tumor Necrosis Factor Production Response To Stilbenoid Regulation Of Apoptotic Process Negative Regulation Of Cytokine Secretion Negative Regulation Of Lipid Catabolic Process Negative Regulation Of Execution Phase Of Apoptosis Regulation Of Apoptotic DNA Fragmentation	Regulation Of Transcription From RNA Polymerase II Promoter Mitochondrial Transport Proton Transport Respiratory Electron Transport Chain Cellular Metabolic Process Small Molecule Metabolic Process Brown Fat Cell Differentiation
Pathways			Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. The proton buffering model Mitochondrial Uncoupling Proteins The fatty acid cycling model The citric acid (TCA) cycle and respiratory electron transport
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: CIDEB UCP1 ZBTB16	2 interactors: CIDEA TOMM20
Entrez ID		1149	7350
HPRD ID		08380	00221
Ensembl ID
Uniprot IDs		O60543 Q8N5P9	P25874 Q4KMT7
PDB IDs		2EEL
Enriched GO Terms of Interacting Partners?		Positive Regulation Of NK T Cell Differentiation Male Germ-line Stem Cell Asymmetric Division	Positive Regulation Of Sequestering Of Triglyceride Regulation Of Apoptotic DNA Fragmentation Negative Regulation Of Execution Phase Of Apoptosis Response To Stilbenoid Negative Regulation Of Lipid Catabolic Process Temperature Homeostasis Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Lipid Storage Negative Regulation Of Cytokine Secretion Lipid Storage Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Lipid Catabolic Process Regulation Of Lipid Storage Protein Transmembrane Transport Protein Targeting To Mitochondrion Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Localization To Mitochondrion Negative Regulation Of Lipid Metabolic Process Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Protein Secretion Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cytokine Secretion
Tagcloud ?		acot11 adipose adiposity beige bfit brite brown chow contributor cpt1beta dexa dio2 ehmt1 erralpha lean littermates orphan pparalpha prdm16 resist roralpha sg stabilizes staggerer thermogenesis thermogenic thermography ucp1 uncoupling	1s adipocyte adipose ap2 bip carbonylation chop concomitant enigmatic equilibrium fabp fabp4 fatty ffa herein hts01037 indirectly lipopolysaccharide macrophages negated null palmitate pharmacologic r126q ucp2 ucp3 uncouples uncoupling xbp
Tagcloud (Difference) ?		acot11 adiposity beige bfit brite brown chow contributor cpt1beta dexa dio2 ehmt1 erralpha lean littermates orphan pparalpha prdm16 resist roralpha sg stabilizes staggerer thermogenesis thermogenic thermography	1s adipocyte ap2 bip carbonylation chop concomitant enigmatic equilibrium fabp fabp4 fatty ffa herein hts01037 indirectly lipopolysaccharide macrophages negated null palmitate pharmacologic r126q ucp2 ucp3 uncouples xbp
Tagcloud (Intersection) ?		adipose ucp1 uncoupling