CCNB1IP1 and NF2

Number of citations of the paper that reports this interaction (PubMedID 16532029)
0

Data Source:
BioGRID (two hybrid)

		CCNB1IP1	NF2
Description		cyclin B1 interacting protein 1	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor
Image		No pdb structure
GO Annotations	Cellular Component	Condensed Nuclear Chromosome Synaptonemal Complex Nucleus Chromosome	Ruffle Nucleus Nucleolus Cytoplasm Early Endosome Cytosol Cytoskeleton Plasma Membrane Adherens Junction Membrane Lamellipodium Filopodium Cortical Actin Cytoskeleton Filopodium Membrane Cleavage Furrow Ruffle Membrane Cell Projection Neuron Projection Cell Body Apical Part Of Cell Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Actin Binding Integrin Binding Protein Binding Cytoskeletal Protein Binding
	Biological Process	Blastocyst Formation Reciprocal Meiotic Recombination Spermatid Development Protein Ubiquitination Chiasma Assembly Meiotic Cell Cycle	MAPK Cascade Mesoderm Formation Negative Regulation Of Cell-matrix Adhesion Ectoderm Development Brain Development Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Negative Regulation Of Schwann Cell Proliferation Schwann Cell Proliferation Regulation Of Gliogenesis Hippocampus Development Negative Regulation Of Cell-cell Adhesion Actin Cytoskeleton Organization Cell Differentiation Negative Regulation Of Cell Migration Regulation Of Protein Stability Osteoblast Proliferation Negative Regulation Of Osteoblast Proliferation Regulation Of Hippo Signaling Regulation Of Cell Population Proliferation Odontogenesis Of Dentin-containing Tooth Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Cell-cell Junction Organization Positive Regulation Of Cell Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Neurogenesis Positive Regulation Of Stress Fiber Assembly Regulation Of Cell Cycle Lens Fiber Cell Differentiation Regulation Of Stem Cell Proliferation Regulation Of Protein Localization To Nucleus Regulation Of Organelle Assembly Positive Regulation Of Protein Localization To Early Endosome Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Early Endosome To Late Endosome Transport
Pathways			Regulation of actin dynamics for phagocytic cup formation RHO GTPases activate PAKs
Drugs
Diseases			Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS) Malignant pleural mesothelioma
GWAS			Carotid atherosclerosis in HIV infection ( 20009918)
Interacting Genes		12 interacting genes: APP CCNB1 CDK1 CUL5 EPM2AIP1 KEAP1 KRT15 NF2 NTAQ1 PRKAA2 SYT17 UBE2L3	72 interacting genes: AGAP2 AKT1 AMOTL2 ARAF ARNT AURKA BDKRB1 BECN1 BYSL CBLC CCNB1IP1 CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2B CDKN2C CTNNB1 DACH1 DCAF1 DSCAM EGFR EIF3B EMD EPHA2 ERBB2 EZR FGFR4 FZR1 GLIS2 GRM1 HGF HGS HIF1A IGF1R ITGB1 KAT2A KDELR2 MAP2K3 MAP2K5 MAP3K5 MAPK14 MDM4 MED28 MET MYBPC2 MYC NHERF1 PAK1 PDGFRA PRKCA PXN PYGO2 RAF1 RALGDS RASSF1 RSPH1 SCHIP1 SDCBP SGSM3 SOX3 SOX4 SPTBN1 STK11 TARBP2 TERT TP53 TSC1 TTYH2 TXLNB XPO1
Entrez ID		57820	4771
HPRD ID		07000	06980
Ensembl ID		ENSG00000100814	ENSG00000186575
Uniprot IDs		A0A384MR52 Q9NPC3	A0A5K1VW66 P35240
PDB IDs			1H4R 3U8Z 4ZRI 4ZRJ 6CDS 7LWH
Enriched GO Terms of Interacting Partners?		Regulation Of Generation Of Precursor Metabolites And Energy Cyclin B1-CDK1 Complex Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Cell Cycle Phase Transition Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Ventricular Cardiac Muscle Cell Development Protein Polyubiquitination Regulation Of Developmental Growth Response To Metal Ion Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Small Molecule Metabolic Process Regulation Of Protein Localization To Nucleus Positive Regulation Of Glycolytic Process Nucleus Positive Regulation Of Protein Localization Mitotic Cell Cycle Phase Transition Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Developmental Growth Positive Regulation Of Cardiac Muscle Cell Proliferation Post-translational Protein Modification Positive Regulation Of Chromosome Segregation Cellular Response To Metal Ion Positive Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Protein Localization Response To Copper Ion Positive Regulation Of ATP Metabolic Process Positive Regulation Of Heart Growth Cytosol Negative Regulation Of Cell-matrix Adhesion Cardiac Muscle Cell Development Protein K11-linked Ubiquitination Cellular Response To Oxidative Stress Regulation Of Cardiac Muscle Cell Proliferation Protein Modification Process Cardiac Cell Development Regulation Of Developmental Process Positive Regulation Of Cellular Component Organization Amyloid-beta Complex Regulation Of Cellular Component Organization Growth Cone Lamellipodium Regulation Of Growth Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Organ Growth Response To DDT Cell Cycle G2/M Phase Transition	Regulation Of Cell Population Proliferation Regulation Of Intracellular Signal Transduction Regulation Of Cell Cycle Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Population Proliferation Kinase Activity Protein Kinase Activity Regulation Of MAPK Cascade Signal Transduction Positive Regulation Of Signal Transduction Animal Organ Development Regulation Of Cell Cycle Process Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Differentiation Regulation Of Cellular Component Organization Response To Growth Factor Positive Regulation Of Intracellular Signal Transduction Regulation Of Fibroblast Proliferation Negative Regulation Of Apoptotic Process Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Cell Population Proliferation Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Developmental Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Phosphate Metabolic Process Regulation Of Developmental Process Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Cellular Developmental Process Regulation Of Protein Localization Regulation Of Protein Modification Process Negative Regulation Of Cell Population Proliferation Regulation Of Programmed Cell Death Protein Serine Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Phosphorylation Regulation Of Mitotic Cell Cycle
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