KRTAP2-3 and CTSZ

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRTAP2-3	CTSZ
Description		keratin associated protein 2-3	cathepsin Z
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament Keratin Filament	Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Plasma Membrane Cell Cortex Cell Surface COPII-coated ER To Golgi Transport Vesicle Growth Cone Extracellular Matrix Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Specific Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding	Carboxypeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Cysteine-type Carboxypeptidase Activity
	Biological Process		Angiotensin Maturation Proteolysis Negative Regulation Of Plasminogen Activation Proteolysis Involved In Protein Catabolic Process Epithelial Tube Branching Involved In Lung Morphogenesis
Pathways		Keratinization Keratinization	Metabolism of Angiotensinogen to Angiotensins COPII-mediated vesicle transport Lysosome Vesicle Biogenesis Cargo concentration in the ER Neutrophil degranulation
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) Heel bone mineral density x serum urate levels interaction ( 34046847) Hematocrit ( 32888494) Inflammatory bowel disease ( 23128233) Lymphocyte count ( 32888494) Mean platelet volume ( 22139419 24026423 27863252 32888494) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494)
Interacting Genes		94 interacting genes: ADAMTSL3 BAHD1 BCL6B BEX2 C11orf87 CATSPER1 CHIC2 CREB5 CTSZ CXCL16 CYSRT1 DHX57 DMRT3 FAM161A GEMIN4 GGN HAPLN2 HHEX HOXA1 HOXB9 IGSF8 ITGB4 JOSD1 KLHL38 KRTAP1-1 KRTAP10-1 KRTAP12-4 KRTAP2-4 KRTAP4-11 KRTAP4-12 KRTAP4-4 KRTAP5-11 KRTAP5-2 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE5A LNX1 MCRS1 MOBP NBPF19 NKD1 NOTCH2NLA NPDC1 NUFIP2 OTX1 P2RY6 PHLDA1 PIGS PRKAB2 RHBDL1 SDC3 SHFL SPATA3 SPRED2 TFAP2D TNP2 TRIM42 TTPA VASN VWC2 YY1 ZBTB24 ZDHHC1 ZIM2 ZNF165 ZNF264 ZNF440 ZNF491 ZNF524 ZNF564 ZNF575 ZNF578 ZNF581 ZNF587 ZNF672 ZNF764 ZNF786 ZNF792	21 interacting genes: BACH2 BANP CYSRT1 FHL5 HSF2BP KRT35 KRT40 KRTAP1-1 KRTAP10-1 KRTAP10-10 KRTAP2-3 KRTAP2-4 KRTAP3-3 KRTAP5-9 KRTAP6-3 MID2 MTUS2 NBPF19 NOTCH2NLA PLSCR1 TNS2
Entrez ID		730755	1522
HPRD ID			04410
Ensembl ID		ENSG00000212724	ENSG00000101160
Uniprot IDs		P0C7H8 Q9BYR9	Q9UBR2
PDB IDs			1DEU 1EF7
Enriched GO Terms of Interacting Partners?		Keratinization Epidermis Development Intermediate Filament Keratin Filament Tissue Development Protein Binding DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Hair Cycle Zinc Ion Binding Regulation Of Transcription By RNA Polymerase II	Intermediate Filament Keratin Filament
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