CTSZ and KRTAP6-3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CTSZ	KRTAP6-3
Description		cathepsin Z	keratin associated protein 6-3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Plasma Membrane Cell Cortex Cell Surface COPII-coated ER To Golgi Transport Vesicle Growth Cone Extracellular Matrix Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Specific Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Cytosol Intermediate Filament
	Molecular Function	Carboxypeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Cysteine-type Carboxypeptidase Activity	Protein Binding
	Biological Process	Angiotensin Maturation Proteolysis Negative Regulation Of Plasminogen Activation Proteolysis Involved In Protein Catabolic Process Epithelial Tube Branching Involved In Lung Morphogenesis	Keratinization
Pathways		Metabolism of Angiotensinogen to Angiotensins COPII-mediated vesicle transport Lysosome Vesicle Biogenesis Cargo concentration in the ER Neutrophil degranulation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Heel bone mineral density x serum urate levels interaction ( 34046847) Hematocrit ( 32888494) Inflammatory bowel disease ( 23128233) Lymphocyte count ( 32888494) Mean platelet volume ( 22139419 24026423 27863252 32888494) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494)
Interacting Genes		21 interacting genes: BACH2 BANP CYSRT1 FHL5 HSF2BP KRT35 KRT40 KRTAP1-1 KRTAP10-1 KRTAP10-10 KRTAP2-3 KRTAP2-4 KRTAP3-3 KRTAP5-9 KRTAP6-3 MID2 MTUS2 NBPF19 NOTCH2NLA PLSCR1 TNS2	160 interacting genes: ADAMTSL4 AGXT ARID5A ARMC7 ATOSB ATPAF2 AUTS2 BAG4 BEX2 BSCL2 C11orf87 CAMK2A CAMK2B CAMK2G CARHSP1 CCDC120 CCDC24 CCER1 CELF5 CHRD CLCNKA CNNM3 COL8A1 CREB5 CRY2 CTSZ CYSRT1 DALRD3 DHRS1 DMRT3 FADS6 FAM83A FBXW5 FCHO1 FOXD2 FOXD4L1 GATA2 GATA3 GLYCTK GNE GPS2 HAPLN2 HHEX HOXA1 HOXB5 HOXB9 HOXC8 HR HYAL2 ILF2 INCA1 INPP5D ITGB4 KANK2 KPRP KRT20 KRTAP11-1 KRTAP12-2 KRTAP19-2 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP26-1 KRTAP4-4 KRTAP6-1 KRTAP6-2 LAGE3 LCE1A LCE1B LCE1C LCE1E LCE1F LCE2A LCE2B LCE2C LCE3A LCE3C LCE3D LCE3E LCE5A LGALS9 LNX1 MAGED1 MAPK1IP1L MAPKBP1 MBD3L2 MED25 MEIS2 MEOX2 MGAT5B NODAL NOTO NR4A3 OLIG3 OTX1 OXER1 P4HB PATZ1 PCDHB14 PGAP6 PHETA1 PHLDA1 PIGS PITX1 PLSCR4 POU4F2 POU4F3 PPP1R37 PRMT8 PROP1 PRPF31 PRR13 PRR3 PRR35 PSMA1 PVR RAB3IL1 RAD54L2 RASD1 RHBDL1 RUNX1T1 SAMD7 SAXO4 SAXO5 SEMA4C SH3KBP1 SLC15A2 SLC22A5 SMARCC1 SMARCE1 SMCP SNRPB SNRPC SNX18 STK16 STRA6 TAOK2 TBX2 TBX6 TCAF1 TCF7L2 TEKT4 TENT2 TFAP2D TLE5 TLX3 TNIP1 TNS2 TSPYL6 TYK2 VASN VENTX VSTM4 WDR25 ZBTB32 ZIC1 ZNF414 ZNF497 ZNF575 ZNF79
Entrez ID		1522	337968
HPRD ID		04410	11220
Ensembl ID		ENSG00000101160	ENSG00000212938
Uniprot IDs		Q9UBR2
PDB IDs		1DEU 1EF7
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament	Protein Binding Keratinization Epidermis Development Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Chromatin Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Tissue Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Intermediate Filament Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription DNA Binding Developmental Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Calcium- And Calmodulin-dependent Protein Kinase Complex Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Inner Ear Morphogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process System Development Transcription Regulator Complex Pattern Specification Process Cell Fate Specification Regulation Of Gene Expression Anatomical Structure Morphogenesis Embryonic Morphogenesis Regulation Of Primary Metabolic Process Embryonic Pattern Specification Myoblast Fate Commitment SnRNP Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Dendritic Cell Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
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