KRTAP2-3 and JOSD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRTAP2-3	JOSD1
Description		keratin associated protein 2-3	Josephin domain containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament Keratin Filament	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Hydrolase Activity Deubiquitinase Activity
	Biological Process		Proteolysis Endocytosis Protein Deubiquitination Membrane Biogenesis Cell Motility Membrane Organization
Pathways		Keratinization Keratinization	Josephin domain DUBs
Drugs
Diseases
GWAS			Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Plateletcrit ( 32888494) Resting heart rate ( 27798624) Sleep duration ( 30846698)
Interacting Genes		94 interacting genes: ADAMTSL3 BAHD1 BCL6B BEX2 C11orf87 CATSPER1 CHIC2 CREB5 CTSZ CXCL16 CYSRT1 DHX57 DMRT3 FAM161A GEMIN4 GGN HAPLN2 HHEX HOXA1 HOXB9 IGSF8 ITGB4 JOSD1 KLHL38 KRTAP1-1 KRTAP10-1 KRTAP12-4 KRTAP2-4 KRTAP4-11 KRTAP4-12 KRTAP4-4 KRTAP5-11 KRTAP5-2 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE5A LNX1 MCRS1 MOBP NBPF19 NKD1 NOTCH2NLA NPDC1 NUFIP2 OTX1 P2RY6 PHLDA1 PIGS PRKAB2 RHBDL1 SDC3 SHFL SPATA3 SPRED2 TFAP2D TNP2 TRIM42 TTPA VASN VWC2 YY1 ZBTB24 ZDHHC1 ZIM2 ZNF165 ZNF264 ZNF440 ZNF491 ZNF524 ZNF564 ZNF575 ZNF578 ZNF581 ZNF587 ZNF672 ZNF764 ZNF786 ZNF792	38 interacting genes: ADAMTSL4 CARD10 CYSRT1 FBLN2 KRT27 KRT31 KRT34 KRT40 KRT86 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-4 KRTAP10-8 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP5-9 KRTAP9-2 KRTAP9-3 LNX1 MDFI MID2 MTUS2 NBPF19 NOTCH2NLA PJA1 STUB1 TGM1 TRAF1 TRIM23 TRIM27 TRIM54 TRIM63 UBC USP15 USP21 USP28
Entrez ID		730755	9929
HPRD ID			08823
Ensembl ID		ENSG00000212724	ENSG00000100221
Uniprot IDs		P0C7H8 Q9BYR9	Q15040
PDB IDs
Enriched GO Terms of Interacting Partners?		Keratinization Epidermis Development Intermediate Filament Keratin Filament Tissue Development Protein Binding DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Hair Cycle Zinc Ion Binding Regulation Of Transcription By RNA Polymerase II	Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Identical Protein Binding Intermediate Filament Organization Ubiquitin Protein Ligase Activity Post-translational Protein Modification Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Cytosol Protein Modification Process Ubiquitin-protein Transferase Activity Epidermis Development Negative Regulation Of Viral Transcription Positive Regulation Of Autophagy Suppression Of Viral Release By Host Structural Molecule Activity Supramolecular Fiber Organization Regulation Of Viral Transcription Microtubule Cysteine-type Deubiquitinase Activity Protein Deubiquitination Deubiquitinase Activity
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