KRTAP2-3 and NKD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRTAP2-3	NKD1
Description		keratin associated protein 2-3	NKD inhibitor of Wnt signaling pathway 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament Keratin Filament	Protein Phosphatase Type 2A Complex Cytoplasm Plasma Membrane Membrane
	Molecular Function	Protein Binding	Calcium Ion Binding Protein Binding PDZ Domain Binding Metal Ion Binding
	Biological Process		Eye Photoreceptor Cell Differentiation Axis Elongation Somatic Muscle Development Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Catabolic Process Convergent Extension Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cell Migration Involved In Somitogenic Axis Elongation Positive Regulation Of Non-canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways		Keratinization Keratinization
Drugs
Diseases
GWAS			Copper levels ( 26025379) Crohn's disease ( 22412388 28067908) Inflammatory bowel disease ( 28067908) Systolic blood pressure ( 30224653)
Interacting Genes		94 interacting genes: ADAMTSL3 BAHD1 BCL6B BEX2 C11orf87 CATSPER1 CHIC2 CREB5 CTSZ CXCL16 CYSRT1 DHX57 DMRT3 FAM161A GEMIN4 GGN HAPLN2 HHEX HOXA1 HOXB9 IGSF8 ITGB4 JOSD1 KLHL38 KRTAP1-1 KRTAP10-1 KRTAP12-4 KRTAP2-4 KRTAP4-11 KRTAP4-12 KRTAP4-4 KRTAP5-11 KRTAP5-2 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE5A LNX1 MCRS1 MOBP NBPF19 NKD1 NOTCH2NLA NPDC1 NUFIP2 OTX1 P2RY6 PHLDA1 PIGS PRKAB2 RHBDL1 SDC3 SHFL SPATA3 SPRED2 TFAP2D TNP2 TRIM42 TTPA VASN VWC2 YY1 ZBTB24 ZDHHC1 ZIM2 ZNF165 ZNF264 ZNF440 ZNF491 ZNF524 ZNF564 ZNF575 ZNF578 ZNF581 ZNF587 ZNF672 ZNF764 ZNF786 ZNF792	15 interacting genes: AKT1 CYSRT1 DVL3 KRTAP10-1 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP5-9 KRTAP9-8 MDFI MORF4L1
Entrez ID		730755	85407
HPRD ID			08482
Ensembl ID		ENSG00000212724	ENSG00000140807
Uniprot IDs		P0C7H8 Q9BYR9	Q969G9
PDB IDs
Enriched GO Terms of Interacting Partners?		Keratinization Epidermis Development Intermediate Filament Keratin Filament Tissue Development Protein Binding DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Hair Cycle Zinc Ion Binding Regulation Of Transcription By RNA Polymerase II	Intermediate Filament Keratin Filament Cytosol
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