SRRM4 and ZNF699

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		SRRM4	ZNF699
Name		serine/arginine repetitive matrix 4	zinc finger protein 699
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus
	Molecular Function	RNA Binding MRNA Binding Protein Binding Identical Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing Nervous System Development Sensory Perception Of Sound RNA Splicing Cell Differentiation Neuron Maturation Regulation Of RNA Splicing	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways		None	Generic Transcription Pathway
GWAS		Cerebrospinal fluid t-tau levels in normal cognition ( 29274321 ) Facial morphology (factor 3, length of philtrum) ( 28441456 ) Loneliness ( 27629369 ) Loneliness (linear analysis) ( 27629369 ) Photic sneeze reflex ( 27182965 ) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576 ) Stroke ( 32693751 )	No GWAS studies recorded
Interacting Genes		34 interacting genes: - AKAP17A ARL6IP4 C16orf87 C1orf35 CACNA1A CDC37 CLK1 CLK4 FAM9B LUC7L LUC7L2 LUZP4 MCRS1 PRPF38A RBM25 RBM39 RBMX2 RNPS1 RSRC1 SNIP1 SNRNP70 SREK1 SRRM1 SRSF11 SRSF4 TBC1D26 U2AF1 WDR5 ZNF124 ZNF286A ZNF699 ZRSR2 ZRSR2P1	7 interacting genes: DVL3 EFEMP2 HEXIM2 HRC KRTAP10-3 KRTAP10-9 SRRM4
Entrez ID		84530	374879
HPRD ID		13897	13429
Ensembl ID		ENSG00000139767	ENSG00000196110
Uniprot IDs		A7MD48 V5T9A0	Q32M78
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing RNA Splicing, Via Transesterification Reactions Nuclear Speck Spliceosomal Complex RNA Binding MRNA Splicing, Via Spliceosome Regulation Of RNA Splicing RNA Metabolic Process Nucleic Acid Binding Nucleic Acid Metabolic Process Nucleus Regulation Of MRNA Splicing, Via Spliceosome Pre-mRNA 3'-splice Site Binding RS Domain Binding U2AF Complex Regulation Of MRNA Processing Nucleobase-containing Compound Metabolic Process U2-type Prespliceosome U1 SnRNP MRNA Binding Regulation Of MRNA Metabolic Process Protein-RNA Complex Assembly U1 SnRNP Binding Spliceosomal Complex Assembly U2-type Precatalytic Spliceosome NSL Complex Regulation Of Alternative MRNA Splicing, Via Spliceosome Nucleoplasm Precatalytic Spliceosome Negative Regulation Of MRNA Splicing, Via Spliceosome Histone Acetyltransferase Complex U2-type Prespliceosome Assembly Negative Regulation Of RNA Splicing U2 SnRNP Protein Serine/threonine/tyrosine Kinase Activity MLL1 Complex Histone H3Q5ser Reader Activity MRNA Splice Site Recognition Macromolecule Metabolic Process Negative Regulation Of Protein Refolding Histone H3K4me1 Reader Activity HSP90-CDC37 Chaperone Complex	None