PRR20C and ATXN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PRR20C	ATXN1
Description		proline rich 20C	ataxin 1
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Matrix Protein-containing Complex Nuclear Inclusion Body Postsynapse
	Molecular Function	Protein Binding	DNA Binding Chromatin Binding RNA Binding Protein Binding Poly(U) RNA Binding POZ Domain Binding Poly(G) Binding Identical Protein Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II RNA Processing Brain Development Learning Memory Adult Locomotory Behavior Visual Learning Social Behavior Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Insulin-like Growth Factor Receptor Signaling Pathway Lung Alveolus Development Nuclear Export Excitatory Postsynaptic Potential Positive Regulation Of Glial Cell Proliferation
Pathways
Drugs
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS			Amyotrophic lateral sclerosis ( 19451621) Atrial fibrillation ( 30061737 29892015) Breast cancer ( 29059683) Central corneal thickness ( 32528159) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Cortical amyloid beta load ( 29860282) Fish- and plant-related diet ( 32066663) Gambling ( 22780124) General cognitive ability ( 29844566) Generalized epilepsy ( 30531953) Granulocyte count ( 27863252) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Gut microbiota relative abundance (Ruminococcus belonging to family Lachnospiraceae) ( 33208821) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Household income (MTAG) ( 31844048) Immature fraction of reticulocytes ( 32888494) Lymphocyte percentage of white cells ( 32888494) Major depressive disorder ( 23377640) Metabolite levels ( 23823483) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494 29403010) Neutrophil percentage of white cells ( 32888494) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Subcutaneous adipose tissue attenuation (Hounsfield unit scale) ( 27918534) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 28714469) Total body bone mineral density ( 30172743) Visceral adipose tissue attenuation (Hounslow unit scale) ( 27918534) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 29403010 27863252 32888494)
Interacting Genes		89 interacting genes: ABI2 ANKHD1 ARID5A ATXN1 BANP BEND2 BHLHE40 BICRAL C10orf55 C1orf94 C3orf36 CABP2 CCNK CDC37 CELF4 DAZAP2 DMRT3 DVL3 EIF4ENIF1 ESRP1 FAM168A FAM222B FAM9A FOXH1 FOXP3 GLIS2 GTF2A1 HIVEP1 HLX HYPK KRTAP19-1 KRTAP19-5 LASP1 MAGED1 MBNL3 NCK2 NFYC NOTCH3 NTAQ1 OXER1 PATZ1 PHF1 PITX1 POGZ POU2F1 POU6F2 PRR20A PRR20B PRR20D PRR20E PRR34 PRR35 PTTG2 RBM23 RBM42 RBPMS RBPMS2 RHOXF2 RIPPLY1 RNF4 ROR2 SAMD11 SH3RF1 SIAH1 SMAP1 SNRPB SNRPC SP4 SRPK2 TBX3 TBX6 TCF7L2 TFG THAP1 TIAL1 TLX3 TOLLIP TPRX1 TRIM35 VAC14 VENTX VEZF1 VPS37C YPEL3 ZBTB32 ZC3H10 ZCCHC14 ZNF385C ZNF683	289 interacting genes: - ACACA ACOT7 ADAM15 ADCY6 ADD3 AHDC1 AKT1 ANKHD1 ANP32A APBB1 ARHGAP32 ARID5A ASNS ATF5 ATP1A3 ATP6V0D1 ATXN1L ATXN2 ATXN2L BAALC BASP1 BATF2 BEND2 BHLHE40 BICRAL BLTP3B BRD10 BTG3 C10orf55 C1orf94 CAMK1 CAMK2B CCDC136 CCNK CDIP1 CDK6 CDRT15P3 CFL1 CHRNA7 CIC CIRBP CLASRP CLCN2 CLEC4F COIL CPSF7 CREM CRIP2 CRK CRX CRY2 CST3 CUTC DAZ2 DAZAP2 DCTN3 DHRSX DHX37 DIXDC1 DMPK DNAJA3 DOCK5 DZIP3 EFEMP2 EHMT1 EIF1AY EIF1B EIF3F EIF4ENIF1 ELP5 EML3 ENTPD6 EPN2 ESRP1 ESRRA ETV4 EXTL3 FAM153B FAM168A FAM193B FAR1 FAT4 FDPS FHL2 FNDC9 FOSL1 FOXN4 FUBP3 FYN GAPDH GATAD1 GCA GCFC2 GGA2 GMEB2 GPATCH8 GSPT1 H2AP H3C1 HACL2 HEY2 HEYL HIVEP1 HNRNPLL HOTAIR HPCAL1 HSFX1 HSFY1 HSFY2 HSPA1A IGF2R IL34 IMMT IPO8 IST1 ITGB4 KAT5 KAT6A KCNAB2 KCTD15 KIAA1549L KIF22 KLF11 KLHL12 KLHL8 KMT2B KRTAP12-4 KRTAP13-3 LASP1 LDB1 LITAF LOXL1 LPAR2 LRSAM1 MAGEB18 MAGEB2 MAGEB6 MATN2 MBP MED15 METTL17 METTL27 MLST8 MSMO1 MSX2 MTERF4 MYO18A NARS1 NCAM1 NCOR1 NCOR2 NFYA NHSL2 NLGN3 NLK NPHP3 NR4A1 NUDT21 NUMBL NUTM2B OAZ1 OPCML OTX2 PANX2 PEPD PHPT1 PIAS1 PICALM PIM2 PLA2G10 PLEKHB1 PLEKHN1 PML POGZ POM121 POMP PPAT PPP6R2 PQBP1 PRDM1 PRR20A PRR20B PRR20C PRR20D PRR20E PRRC2A PRRC2B PSMC3 PSPH PTGDS PUM1 QKI QRICH1 R3HDM1 R3HDM2 RAD54L2 RAI2 RAPGEF1 RAPGEF4 RBFOX1 RBFOX2 RBM26 RBPMS RCC1L RCN1 REL RHOXF2 RNF10 RNF31 RNF4 SAR1A SEMA4G SETD2 SETD6 SF1 SGMS1 SIX5 SLC25A51 SLC4A2 SLC51A SLC6A13 SMARCC2 SORCS3 SOX3 SPEN SREBF1 SREBF2 ST6GALNAC6 STAC2 STAM2 SUGP2 SUMO1 SUPT20H SV2A SYBU TBC1D5 TBX15 TCAP TCEANC TCTA TDP2 TENT5A TENT5B TMX2 TOLLIP TOMM20 TOX4 TP53I11 TPRX1 TRAF2 TRIM32 TRIM38 TRIP6 TSC1 TTC19 U2AF2 UBAP2L UBE2E3 UBE2I UBQLN4 UHRF2 UNK USP54 USP7 VCP VSNL1 VSTM2L WASHC2C WNK1 WNK2 YWHAE YWHAZ YY1AP1 ZBTB32 ZC3H10 ZC3H7B ZCCHC13 ZHX1 ZHX2 ZHX3 ZNF276 ZNF488 ZNF609 ZNF804A ZSCAN1 ZSWIM8 ZXDC ZYX
Entrez ID		729240	6310
HPRD ID		19669	03333
Ensembl ID		ENSG00000229665	ENSG00000124788
Uniprot IDs		P86478 P86479 P86480 P86481 P86496	A0A2R8YCF3 P54253 Q96FF1
PDB IDs			1OA8 2M41 4APT 4AQP 4J2J 4J2L 6QIU
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process DNA Binding Nucleus Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Splicing Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Regulation Of MRNA Splicing, Via Spliceosome Sequence-specific DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Binding Sequence-specific Double-stranded DNA Binding Negative Regulation Of Biosynthetic Process Regulation Of MRNA Processing Myoblast Fate Commitment Nucleoplasm Identical Protein Binding Regulation Of MRNA Metabolic Process MRNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Embryonic Axis Specification U1 SnRNP Binding	Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleus Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Protein Binding Chromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process DNA Binding Positive Regulation Of Macromolecule Metabolic Process RNA Binding Negative Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Cytoplasmic Stress Granule Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process MRNA Binding Stress Granule Assembly Nucleoplasm PML Body Nuclear Body Sequence-specific Double-stranded DNA Binding Regulation Of MRNA Stability DNA-binding Transcription Factor Activity Post-transcriptional Regulation Of Gene Expression DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleic Acid Binding Regulation Of MRNA Metabolic Process Regulation Of RNA Stability RNA Stabilization Regulation Of RNA Splicing Membraneless Organelle Assembly Positive Regulation Of Catabolic Process
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