CCR2 and PCMT1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		CCR2	PCMT1
Description		C-C motif chemokine receptor 2	protein-L-isoaspartate (D-aspartate) O-methyltransferase
Image
GO Annotations	Cellular Component	Fibrillar Center Cytoplasm Plasma Membrane External Side Of Plasma Membrane Membrane Dendrite Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Extracellular Exosome Extracellular Vesicle
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity Cytokine Binding C-C Chemokine Binding CCR2 Chemokine Receptor Binding Chemokine (C-C Motif) Ligand 2 Binding Chemokine (C-C Motif) Ligand 12 Binding Chemokine (C-C Motif) Ligand 7 Binding Identical Protein Binding	Protein-L-isoaspartate (D-aspartate) O-methyltransferase Activity Protein Binding Methyltransferase Activity Transferase Activity Cadherin Binding
	Biological Process	Blood Vessel Remodeling Dendritic Cell Chemotaxis Monocyte Chemotaxis Regulation Of T Cell Cytokine Production Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Type 2 Immune Response Intracellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Humoral Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Wounding Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of T Cell Chemotaxis Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Sensory Perception Of Pain Calcium-mediated Signaling Cellular Homeostasis Hemopoiesis Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Tumor Necrosis Factor Production Monocyte Extravasation T-helper 17 Cell Chemotaxis Negative Regulation Of Eosinophil Degranulation Regulation Of T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Homeostasis Of Number Of Cells Within A Tissue Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of T Cell Activation Positive Regulation Of Synaptic Transmission, Glutamatergic Cell Chemotaxis Leukocyte Adhesion To Vascular Endothelial Cell Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Mononuclear Cell Migration Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Inflammatory Response To Wounding Neutrophil Clearance Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Leukocyte Tethering Or Rolling Macrophage Migration Regulation Of Macrophage Migration Regulation Of T Cell Migration Positive Regulation Of Thymocyte Migration Positive Regulation Of Monocyte Extravasation Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Positive Regulation Of Astrocyte Chemotaxis Positive Regulation Of Hematopoietic Stem Cell Migration	Protein Methylation Protein Repair Methylation
Pathways		Beta defensins Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling	Protein repair
Drugs		INCB3284 CCX915 Cenicriviroc Plozalizumab	S-adenosyl-L-homocysteine
Diseases
GWAS		Blood protein levels ( 23696881) Celiac disease ( 22057235 20190752 24999842 25920553) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 26192919) Monocyte count ( 32888494 27863252 29403010) Monocyte percentage of white cells ( 32888494 27863252) Obesity-related traits ( 23251661) Rheumatoid arthritis ( 32868391) Ulcerative colitis ( 28067908 26192919)	Brain morphology (MOSTest) ( 32665545) Serum metabolite levels ( 33031748) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		40 interacting genes: APP ARL6IP5 ATP2B1 B3GAT3 BLOC1S6 CACYBP CD59 CD81 CDIP1 CLPTM1 DMWD EMC10 ERGIC3 GOT1 GPR161 HERPUD1 HMOX2 JPH3 NDFIP1 NOTCH2 NTNG2 PCMT1 PLLP PTPN9 RGR RHOG RTN3 S1PR5 SCG5 SLC2A1 SLC41A3 SRSF5 SUMO1 SVOP TECPR2 TMEM161A TMEM63A TSPAN7 VMA12 WLS	15 interacting genes: AGTR1 APOA1 APOE CCR2 CEBPA CHD3 CLP1 CREBBP CYSLTR2 DLG4 IQCB1 RPIA TAAR1 VKORC1 WEE2-AS1
Entrez ID		729230	5110
HPRD ID		19667	08908
Ensembl ID		ENSG00000121807	ENSG00000120265
Uniprot IDs		P41597	A0A384MDK7 A0A3F2YNX8 B7Z972 F6S8N6 P22061
PDB IDs		2MLO 2MLQ 5T1A 7P8X 7XA3	1I1N 1KR5
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Regulation Of Protein Transport Positive Regulation Of Protein Localization Plasma Membrane Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Catabolic Process Regulation Of Protein Localization Regulation Of Transport Golgi Membrane Nuclear Envelope Lumen Positive Regulation Of Protein Transport Regulation Of Intracellular Protein Transport	Protein-containing Complex Remodeling Positive Regulation Of Cholesterol Metabolic Process Plasma Lipoprotein Particle Remodeling Positive Regulation Of Phospholipid Efflux Positive Regulation Of Steroid Metabolic Process AMPA Glutamate Receptor Clustering Regulation Of Cholesterol Metabolic Process Phosphatidylcholine-sterol O-acyltransferase Activator Activity Lipoprotein Biosynthetic Process High-density Lipoprotein Particle Clearance Regulation Of Inflammatory Response Lipoprotein Particle Binding G Protein-coupled Receptor Signaling Pathway High-density Lipoprotein Particle Assembly Energy Homeostasis Regulation Of Defense Response Intracellular Signaling Cassette Chylomicron Phospholipid Efflux Regulation Of Cdc42 Protein Signal Transduction Neurotransmitter-gated Ion Channel Clustering Positive Regulation Of Phospholipid Transport Low-density Lipoprotein Particle Locomotory Exploration Behavior Low-density Lipoprotein Particle Remodeling Protein-containing Complex Organization Regulation Of Steroid Metabolic Process Reverse Cholesterol Transport Endocytic Vesicle Lumen Cholesterol Metabolic Process Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Remodeling Sterol Metabolic Process High-density Lipoprotein Particle Plasma Lipoprotein Particle Assembly Lipid Transporter Activity Cholesterol Transfer Activity Amyloid Precursor Protein Metabolic Process Regulation Of Lipid Transport Protein-lipid Complex Assembly Positive Regulation Of Lipid Metabolic Process G Protein-coupled Receptor Activity Positive Regulation Of Cholesterol Efflux Plasma Lipoprotein Particle Clearance Positive Regulation Of Cytosolic Calcium Ion Concentration Cholesterol Efflux Positive Regulation Of Small Molecule Metabolic Process Lipoprotein Metabolic Process Lipid Homeostasis Exploration Behavior
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