CCR2 and BLOC1S6

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		CCR2	BLOC1S6
Description		C-C motif chemokine receptor 2	biogenesis of lysosomal organelles complex 1 subunit 6
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Cytoplasm Plasma Membrane External Side Of Plasma Membrane Membrane Dendrite Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm	Stress Fiber Ruffle Cytoplasm Endosome Cytosol Focal Adhesion Membrane Transport Vesicle BLOC-1 Complex Cytoplasmic Vesicle Filamentous Actin Cell-cell Contact Zone Contractile Ring Presynapse Axon Cytoplasm Microvesicle
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity Cytokine Binding C-C Chemokine Binding CCR2 Chemokine Receptor Binding Chemokine (C-C Motif) Ligand 2 Binding Chemokine (C-C Motif) Ligand 12 Binding Chemokine (C-C Motif) Ligand 7 Binding Identical Protein Binding	Protein Binding Syntaxin Binding Identical Protein Binding Protein Homodimerization Activity Actin Filament Binding Molecular Adaptor Activity
	Biological Process	Blood Vessel Remodeling Dendritic Cell Chemotaxis Monocyte Chemotaxis Regulation Of T Cell Cytokine Production Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Type 2 Immune Response Intracellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Humoral Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Wounding Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of T Cell Chemotaxis Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Sensory Perception Of Pain Calcium-mediated Signaling Cellular Homeostasis Hemopoiesis Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Tumor Necrosis Factor Production Monocyte Extravasation T-helper 17 Cell Chemotaxis Negative Regulation Of Eosinophil Degranulation Regulation Of T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Homeostasis Of Number Of Cells Within A Tissue Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of T Cell Activation Positive Regulation Of Synaptic Transmission, Glutamatergic Cell Chemotaxis Leukocyte Adhesion To Vascular Endothelial Cell Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Mononuclear Cell Migration Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Inflammatory Response To Wounding Neutrophil Clearance Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Leukocyte Tethering Or Rolling Macrophage Migration Regulation Of Macrophage Migration Regulation Of T Cell Migration Positive Regulation Of Thymocyte Migration Positive Regulation Of Monocyte Extravasation Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Positive Regulation Of Astrocyte Chemotaxis Positive Regulation Of Hematopoietic Stem Cell Migration	Kidney Development Bradykinin Biosynthetic Process Respiratory System Process Endothelium Development Amino Acid Metabolic Process Glutamate Metabolic Process Glutamine Metabolic Process Protein Targeting Lipid Metabolic Process Phospholipid Metabolic Process Blood Coagulation Memory Anterograde Axonal Transport Protein Secretion Response To Xenobiotic Stimulus Gene Expression Response To Activity Synaptic Vesicle Docking Dentate Gyrus Development Hypothalamus Development Melanocyte Differentiation Lung Development Neuron Projection Development Melanosome Transport Melanosome Organization Positive Regulation Of Natural Killer Cell Activation Secretion Of Lysosomal Enzymes Intracellular Nitric Oxide Homeostasis Multicellular Organism Growth Endosome To Melanosome Transport Vasodilation Circadian Sleep/wake Cycle Pigmentation ATP Metabolic Process Adenosine Metabolic Process Intracellular Transport Lung Alveolus Development Anterograde Synaptic Vesicle Transport Homeostasis Of Number Of Cells Positive Regulation Of Pigment Cell Differentiation Actin Filament Bundle Assembly Lipid Homeostasis Cilium Assembly Membrane Fusion Cellular Response To Epidermal Growth Factor Stimulus Protein Transmembrane Transport Response To Acetylcholine
Pathways		Beta defensins Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling	Golgi Associated Vesicle Biogenesis
Drugs		INCB3284 CCX915 Cenicriviroc Plozalizumab
Diseases
GWAS		Blood protein levels ( 23696881) Celiac disease ( 22057235 20190752 24999842 25920553) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 26192919) Monocyte count ( 32888494 27863252 29403010) Monocyte percentage of white cells ( 32888494 27863252) Obesity-related traits ( 23251661) Rheumatoid arthritis ( 32868391) Ulcerative colitis ( 28067908 26192919)
Interacting Genes		40 interacting genes: APP ARL6IP5 ATP2B1 B3GAT3 BLOC1S6 CACYBP CD59 CD81 CDIP1 CLPTM1 DMWD EMC10 ERGIC3 GOT1 GPR161 HERPUD1 HMOX2 JPH3 NDFIP1 NOTCH2 NTNG2 PCMT1 PLLP PTPN9 RGR RHOG RTN3 S1PR5 SCG5 SLC2A1 SLC41A3 SRSF5 SUMO1 SVOP TECPR2 TMEM161A TMEM63A TSPAN7 VMA12 WLS	49 interacting genes: ABI2 AGGF1 ANK1 APP BLOC1S1 BLOC1S2 BLOC1S4 C4orf46 CCDC136 CCDC22 CCHCR1 CCR2 CDK5R1 CEP44 CORO6 DCTN2 DTNBP1 EPS8 EXOC8 HAUS1 IFT20 INSYN1 KRT13 KRT72 LURAP1 MED21 MLPH NDC80 NDN NTAQ1 NUP62 OLFM2 PLEKHA5 PLEKHF2 RABGEF1 RINT1 SKA1 SLC4A1 SMN1 SMN2 SNAPIN STX11 STX12 STX1A SYCE3 TPM1 TPM3 TRAK1 WASHC3
Entrez ID		729230	26258
HPRD ID		19667	16055
Ensembl ID		ENSG00000121807	ENSG00000104164
Uniprot IDs		P41597	B3KY40 H3BST1 Q9UL45
PDB IDs		2MLO 2MLQ 5T1A 7P8X 7XA3
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Regulation Of Protein Transport Positive Regulation Of Protein Localization Plasma Membrane Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Catabolic Process Regulation Of Protein Localization Regulation Of Transport Golgi Membrane Nuclear Envelope Lumen Positive Regulation Of Protein Transport Regulation Of Intracellular Protein Transport	Organelle Localization BLOC-1 Complex Establishment Of Localization In Cell Intracellular Transport Cellular Localization Axo-dendritic Transport Organelle Organization Establishment Of Organelle Localization Microtubule-based Process Establishment Of Vesicle Localization Anterograde Synaptic Vesicle Transport Vesicle Organization Transport Along Microtubule Vesicle Localization Vesicle Transport Along Microtubule Cytoskeleton-dependent Intracellular Transport Microtubule-based Transport Vesicle Cytoskeletal Trafficking Axon Cytoplasm Axonal Transport Protein Transport Establishment Of Protein Localization Synaptic Vesicle Transport Melanosome Organization Pigment Granule Organization Vesicle-mediated Transport Anterograde Axonal Transport Organelle Transport Along Microtubule Intracellular Protein Localization Cytoplasm Cytosol Neuron Projection Neuron Projection Development Regulation Of Lysosome Size BORC Complex Microtubule-based Movement Exocytosis Growth Cone Cytoskeleton Organization Perikaryon Regulation Of Endosome Size Cytoplasmic Side Of Lysosomal Membrane Cell Projection Organization Supramolecular Fiber Organization Regulation Of Supramolecular Fiber Organization Centrosome Secretion By Cell Regulation Of Vesicle Size Lysosome Localization PTB Domain Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?