HIRA and H3F3B

Number of citations of the paper that reports this interaction (PMID 9731536)
29

Data Source:
HPRD (in vitro, two hybrid)

		HIRA	H3F3B
Gene Name		histone cell cycle regulator	H3 histone, family 3B (H3.3B)
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm PML Body Protein Complex Extracellular Vesicular Exosome	Nuclear Chromosome Nuclear Nucleosome Extracellular Region Nucleus Nucleoplasm Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Protein Binding Nucleosomal DNA Binding Protein Heterodimerization Activity
	Biological Process	Osteoblast Differentiation DNA Replication-independent Nucleosome Assembly Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Gastrulation Anatomical Structure Morphogenesis Chromatin Modification Muscle Cell Differentiation Negative Regulation Of Nucleic Acid-templated Transcription	Chromatin Silencing At RDNA DNA Replication-independent Nucleosome Assembly Blood Coagulation Gene Expression Positive Regulation Of Cell Growth DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic
Pathways		DNA Damage/Telomere Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Cellular Senescence	RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Cellular Senescence Signaling by Wnt M Phase Amyloids NoRC negatively regulates rRNA expression RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression Factors involved in megakaryocyte development and platelet production PRC2 methylates histones and DNA Cell Cycle, Mitotic Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: ASF1A ASF1B CCNA2 CDK2 H3F3B HIRIP3 HIST1H2BD HIST1H2BK HIST2H2BE HNRNPD NFU1 PAX7 SUMO1 UBN1 UPF1	6 interactors: CARM1 EHMT2 HIRA KAT5 NASP UHRF1
Entrez ID		7290	3021
HPRD ID		02583	03036
Ensembl ID		ENSG00000100084	ENSG00000132475
Uniprot IDs		P54198	B2R4P9 P84243
PDB IDs		2I32	2L43 3ASK 3ASL 3AV2 3JVK 3MUK 3MUL 3QL9 3QLA 3QLC 4GNE 4GNF 4GNG 4GU0 4GUR 4GUS 4GY5 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA 4L58
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromosome Organization Chromatin Assembly Or Disassembly DNA Replication-independent Nucleosome Assembly Nucleosome Assembly Organelle Organization Chromatin Assembly Nucleosome Organization Protein-DNA Complex Assembly DNA Packaging DNA Conformation Change DNA Replication-dependent Nucleosome Assembly Chromatin Modification Cellular Macromolecular Complex Assembly Innate Immune Response In Mucosa Response To Stress Regulation Of Gene Silencing Cellular Response To DNA Damage Stimulus Antibacterial Humoral Response Regulation Of Gene Expression Antimicrobial Humoral Response Mucosal Immune Response Regulation Of Gene Expression, Epigenetic Protein Complex Assembly Regulation Of Transcription, DNA-templated DNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process DNA Repair Regulation Of RNA Metabolic Process Cellular Component Assembly Skeletal Muscle Satellite Cell Commitment Regulation Of Cellular Protein Metabolic Process Defense Response To Gram-positive Bacterium Positive Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Metabolic Process Mitotic DNA Damage Checkpoint Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Mitotic DNA Integrity Checkpoint Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process PML Body Organization Positive Regulation Of DNA-dependent DNA Replication Initiation G2/M Transition Of Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Protein Localization To Nuclear Pore Positive Regulation Of Myoblast Proliferation	Chromatin Modification Chromatin Organization Chromosome Organization Histone Modification DNA Methylation On Cytosine Organelle Organization DNA Replication-independent Nucleosome Assembly Nucleobase-containing Compound Metabolic Process DNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process DNA Methylation Cellular Nitrogen Compound Metabolic Process Methylation Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process DNA Modification Histone H3-R17 Methylation Nucleosome Assembly Histone Methylation Cellular Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Assembly Macromolecule Biosynthetic Process Histone H3-R2 Methylation Nucleosome Organization Chromatin Assembly Or Disassembly Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein-DNA Complex Assembly Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Protein Methylation Negative Regulation Of Cellular Metabolic Process DNA Packaging DNA Methylation On Cytosine Within A CG Sequence Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Regulation Of Transcription, DNA-templated Intracellular Receptor Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Regulation Of Gene Expression, Epigenetic Peptidyl-amino Acid Modification Regulation Of RNA Metabolic Process RNA Biosynthetic Process Peptidyl-lysine Modification Negative Regulation Of Transcription, DNA-templated Biosynthetic Process
Tagcloud ?		actively cabin1 caf calcineurin concomitantly constituting coordinated copyright crosses deposit extractable fertility heterochromatic impacts imply inheritance nucleosome occupancy orthologs pericentromeric preserve rescues reserved rights transcribed transposons ubinuclein ubn	abnormal additionally disruption diverse dynamics encoding exhibited germ incorporation infertility knockout modifications morphology notably null occurring phenotypic prominent protamine reorganization reprogramming sperm spermatocytes spermatogenesis spermatogonia testes translational variant
Tagcloud (Difference) ?		actively cabin1 caf calcineurin concomitantly constituting coordinated copyright crosses deposit extractable fertility heterochromatic impacts imply inheritance nucleosome occupancy orthologs pericentromeric preserve rescues reserved rights transcribed transposons ubinuclein ubn	abnormal additionally disruption diverse dynamics encoding exhibited germ incorporation infertility knockout modifications morphology notably null occurring phenotypic prominent protamine reorganization reprogramming sperm spermatocytes spermatogenesis spermatogonia testes translational variant
Tagcloud (Intersection) ?