HIRA and H2BC12

Number of citations of the paper that reports this interaction (PubMedID 9710638)
54

Data Source:
BioGRID (pull down)

		HIRA	H2BC12
Description		histone cell cycle regulator	H2B clustered histone 12
Image
GO Annotations	Cellular Component	HIR Complex Chromatin Nucleus Nucleoplasm PML Body Protein-containing Complex Extracellular Exosome	Nucleosome Extracellular Space Nucleus Nucleoplasm Chromosome Cytosol
	Molecular Function	Transcription Corepressor Activity Protein Binding Nucleosome Binding Histone Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	Osteoblast Differentiation Chromatin Organization Nucleosome Assembly Chromatin Remodeling DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Gastrulation Anatomical Structure Morphogenesis Muscle Cell Differentiation Negative Regulation Of DNA-templated Transcription	Innate Immune Response In Mucosa Antibacterial Humoral Response Killing Of Cells Of Another Organism Defense Response To Bacterium Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		Formation of Senescence-Associated Heterochromatin Foci (SAHF) Replacement of protamines by nucleosomes in the male pronucleus	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Replacement of protamines by nucleosomes in the male pronucleus MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872)
Interacting Genes		18 interacting genes: ASF1A CCNA2 CDK2 H2BC12 H2BC21 H2BC5 H3-3B HIRIP3 HNRNPD NFU1 OGT PAX7 RPA1 RPA2 TRIM55 TRIM63 UBE2I UPF1	3 interacting genes: CLK1 HIRA SRPK2
Entrez ID		7290	85236
HPRD ID		02583	13658
Ensembl ID		ENSG00000100084	ENSG00000197903
Uniprot IDs		P54198	O60814
PDB IDs		2I32 5YJE	2CV5 6KE9 6L9H 6LE9 6T79 6T7A 6T7B 6T7C 6T7D 6V92 6Y5D 7BWD 7DBP 7JZV 7PET 7PEU 7PEV 7PEW 7PEX 7PEY 7PEZ 7PF0 7PF2 7PF3 7PF4 7PF5 7PF6 7PFA 7PFC 7PFD 7PFE 7PFF 7PFT 7PFU 7PFV 7PFW 7PFX 7V90 7V96 7V99 7V9C 7V9J 7V9K 7V9S 7VA4 7XCR 7XCT 7XD1 8GRQ 8HQY 8HR1 8IEG 8IEJ 8JHF 8JHG 8Q36 8Q3E 8Q3M 8Q3X 8W9D 8W9E 8W9F 8WG5 8X7I 8X7J 8X7K 8YV8 9IPU
Enriched GO Terms of Interacting Partners?		Nucleus Nucleoplasm Telomere Organization Cellular Response To Nitric Oxide Cellular Response To Reactive Nitrogen Species Chromatin Organization Chromosome, Telomeric Region Response To Nitric Oxide Structural Constituent Of Chromatin Cyclin A2-CDK2 Complex Telomere Maintenance Telomeric DNA Binding Nucleosome DNA Replication Chromosome Organization G-rich Strand Telomeric DNA Binding Response To Stress DNA Replication Factor A Complex Regulation Of Chromosome Organization DNA Binding Regulation Of DNA Metabolic Process Mitotic G1 DNA Damage Checkpoint Signaling Macromolecule Metabolic Process Mitotic G1/S Transition Checkpoint Signaling DNA Repair Site Of Double-strand Break 3'-UTR-mediated MRNA Destabilization Nucleosome Assembly Protein Localization To Chromosome PML Body Innate Immune Response In Mucosa Regulation Of Chromatin Organization Nucleosome Organization Double-strand Break Repair Via Homologous Recombination Protein Heterodimerization Activity Recombinational Repair Mismatch Repair Mucosal Immune Response Chromatin Remodeling Nucleic Acid Metabolic Process Chromosome Organ Or Tissue Specific Immune Response Chromatin Cell Cycle Phase Transition Condensed Chromosome Cellular Response To Estradiol Stimulus Base-excision Repair Response To Electrical Stimulus DNA Metabolic Process Positive Regulation Of DNA Biosynthetic Process	Regulation Of RNA Splicing HIR Complex Nuclear Speck Organization Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity R-loop Processing
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?