H3-3B and NASP

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		H3-3B	NASP
Description		H3.3 histone B	nuclear autoantigenic sperm protein
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromosome, Telomeric Region Chromatin Nucleosome Inner Kinetochore Barr Body Extracellular Region Nucleus Nucleoplasm Chromosome Protein-containing Complex Extracellular Exosome	Chromatin Nucleus Nucleoplasm Cytoplasm Protein-containing Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA Binding Protein Binding Structural Constituent Of Chromatin Nucleosomal DNA Binding Protein Heterodimerization Activity	Protein Binding Histone Binding Protein-containing Complex Binding
	Biological Process	Oocyte Maturation Osteoblast Differentiation Nucleosome Assembly Nucleus Organization Spermatogenesis Spermatid Development Single Fertilization Embryo Implantation Cell Population Proliferation Male Gonad Development Positive Regulation Of Cell Growth Pericentric Heterochromatin Formation Subtelomeric Heterochromatin Formation Telomere Organization Multicellular Organism Growth Muscle Cell Differentiation Oogenesis Regulation Of Centromere Complex Assembly Negative Regulation Of Chromosome Condensation	Blastocyst Development DNA Replication Nucleosome Assembly DNA Replication-dependent Chromatin Assembly Male Gonad Development Protein Transport Response To Testosterone CENP-A Containing Chromatin Assembly
Pathways		Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Assembly of the ORC complex at the origin of replication RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Replacement of protamines by nucleosomes in the male pronucleus Factors involved in megakaryocyte development and platelet production MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS			Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		9 interacting genes: CARM1 DAXX EHMT2 ESR1 FBXO7 HIRA KAT5 NASP TIAM1	22 interacting genes: CDC42 FXR2 H1-1 H1-2 H3-3B H3-4 H3-5 H3C10 H3C13 H3C14 H3C4 H3C8 HDAC6 ITSN1 LUC7L2 MTNR1A OGT PTK2 TERF2 TERF2IP TIAM1 ULK2
Entrez ID		3021	4678
HPRD ID		03036	04423
Ensembl ID		ENSG00000132475	ENSG00000132780
Uniprot IDs		B2R4P9 P84243	P49321 Q5T626
PDB IDs		2L43 3ASK 3ASL 3AV2 3JVK 3MUK 3MUL 3QL9 3QLA 3QLC 3WTP 4GNE 4GNF 4GNG 4GU0 4GUR 4GUS 4GY5 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA 4L58 4N4I 4O62 4QQ4 4TMP 4U7T 4W5A 5B32 5B33 5BNV 5BNX 5DWQ 5DX0 5JA4 5JJY 5JLB 5KDM 5X7X 6A5L 6A5O 6A5P 6A5R 6A5T 6A5U 6HGT 6INQ 6IR9 6J4W 6J4X 6J4Y 6J4Z 6J50 6J51 6J9J 6PZV 6QXZ 6R0C 6RNY 6U04 7A08 7CIZ 7CJ0 7CWH 7OKP 7V1L 7V1M 7VCQ 7W5M 7WBV 7WBW 7WBX 7XSE 7XSX 7XSZ 7XT7 7XTD 7XTI 8JH2 8JH3 8JH4 8KB5 9B3P 9EOZ 9J0N 9J0O 9J0P	7V1K 7V1L 7V1M 7V6P 7V6Q
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromatin Organization Protein-DNA Complex Assembly Nucleosome Assembly Cellular Component Assembly Nucleosome Organization Nucleoplasm Histone Binding Chromatin Regulation Of Macroautophagy Cellular Response To Estradiol Stimulus Histone Methyltransferase Activity Intracellular Receptor Signaling Pathway Protein-containing Complex Assembly Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Negative Regulation Of RNA Metabolic Process Regulation Of Apoptotic Process Transcription Coactivator Activity Protein-containing Complex Organization Chromosome Regulation Of Epithelial Cell Apoptotic Process Organ Growth Protein-containing Complex Transcription Corepressor Binding HIR Complex Histone H2AK5 Acetyltransferase Activity Histone H3K56 Methyltransferase Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite P53 Binding Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Developmental Process Involved In Reproduction Regulation Of Autophagy Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Cellular Response To Diamide Histone H3R2 Methyltransferase Activity Histone H3R17 Methyltransferase Activity Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Crotonyltransferase Activity Positive Regulation Of Macroautophagy Protein Kinase Binding Nuclear Receptor-mediated Signaling Pathway PML Body	Structural Constituent Of Chromatin Nucleosome Nucleosome Assembly Nucleosome Organization Protein-DNA Complex Assembly Chromosome Protein-containing Complex Organization Protein Heterodimerization Activity Protein-containing Complex Assembly Cellular Component Assembly Chromatin Organization Chromatin Remodeling Chromosome Organization Telomere Organization Nucleosomal DNA Binding Negative Regulation Of DNA Recombination Epigenetic Regulation Of Gene Expression Negative Regulation Of DNA Recombination At Telomere Regulation Of Cellular Component Organization Shelterin Complex Organelle Organization Negative Regulation Of Cellular Component Organization Negative Regulation Of DNA Metabolic Process DNA Binding Regulation Of DNA Recombination Protection From Non-homologous End Joining At Telomere Gene Expression Protein-containing Complex Macromolecule Biosynthetic Process Nuclear Telomere Cap Complex Mitophagy Euchromatin Nucleus G-rich Strand Telomeric DNA Binding Chromosome, Telomeric Region Protein Localization To Chromosome, Telomeric Region Nucleoplasm Telomere Capping Autophagy Of Mitochondrion Telomere Maintenance In Response To DNA Damage Negative Regulation Of Chromosome Organization Regulation Of Cell Growth Chromatin DNA Binding Collateral Sprouting Dendritic Spine Morphogenesis Positive Regulation Of Cellular Component Organization RNA-templated DNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Telomeric DNA Binding Negative Regulation Of Protein-containing Complex Assembly
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