HIRA

Name	histone cell cycle regulator
Structure
Interactors	18 interactors: ASF1A CCNA2 CDK2 H2BC12 H2BC21 H2BC5 H3-3B HIRIP3 HNRNPD NFU1 OGT PAX7 RPA1 RPA2 TRIM55 TRIM63 UBE2I UPF1
GO Annotations	Cellular Component	HIR Complex Chromatin Nucleus Nucleoplasm PML Body Protein-containing Complex Extracellular Exosome
	Molecular Function	Transcription Corepressor Activity Protein Binding Nucleosome Binding Histone Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Osteoblast Differentiation Chromatin Organization Nucleosome Assembly Chromatin Remodeling DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Gastrulation Anatomical Structure Morphogenesis Muscle Cell Differentiation Negative Regulation Of DNA-templated Transcription
Pathways	Formation of Senescence-Associated Heterochromatin Foci (SAHF) Replacement of protamines by nucleosomes in the male pronucleus
GWAS	Cognitive decline rate in late mild cognitive impairment ( 26252872 )
Entrez ID	7290
HPRD ID	02583
Ensembl ID	ENSG00000100084
Uniprot IDs	P54198
PDB IDs	2I32 5YJE
GO Terms Enriched among Interactors ?	Nucleus Nucleoplasm Telomere Organization Cellular Response To Nitric Oxide Cellular Response To Reactive Nitrogen Species Chromatin Organization Chromosome, Telomeric Region Response To Nitric Oxide Structural Constituent Of Chromatin Cyclin A2-CDK2 Complex Telomere Maintenance Telomeric DNA Binding Nucleosome DNA Replication Chromosome Organization G-rich Strand Telomeric DNA Binding Response To Stress DNA Replication Factor A Complex Regulation Of Chromosome Organization DNA Binding Regulation Of DNA Metabolic Process Mitotic G1 DNA Damage Checkpoint Signaling Macromolecule Metabolic Process Mitotic G1/S Transition Checkpoint Signaling DNA Repair Site Of Double-strand Break 3'-UTR-mediated MRNA Destabilization Nucleosome Assembly Protein Localization To Chromosome PML Body Innate Immune Response In Mucosa Regulation Of Chromatin Organization Nucleosome Organization Double-strand Break Repair Via Homologous Recombination Protein Heterodimerization Activity Recombinational Repair Mismatch Repair Mucosal Immune Response Chromatin Remodeling Nucleic Acid Metabolic Process Chromosome Organ Or Tissue Specific Immune Response Chromatin Cell Cycle Phase Transition Condensed Chromosome Cellular Response To Estradiol Stimulus Base-excision Repair Response To Electrical Stimulus DNA Metabolic Process Positive Regulation Of DNA Biosynthetic Process