COQ3 and NDRG4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		COQ3	NDRG4
Description		coenzyme Q3, methyltransferase	NDRG family member 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane Extrinsic Component Of Mitochondrial Inner Membrane Ubiquinone Biosynthesis Complex	Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Cell Projection Membrane
	Molecular Function	Protein Binding Methyltransferase Activity O-methyltransferase Activity Polyprenyldihydroxybenzoate Methyltransferase Activity Transferase Activity 3-demethylubiquinol 3-O-methyltransferase Activity 3-demethylubiquinone 3-O-methyltransferase Activity	Molecular_function Protein Binding
	Biological Process	Glycerol Metabolic Process Ubiquinone Biosynthetic Process Methylation	Heart Looping Signal Transduction Visual Learning Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Neuron Projection Development Negative Regulation Of Smooth Muscle Cell Migration Cell Differentiation Embryonic Heart Tube Development Vesicle Docking Negative Regulation Of Smooth Muscle Cell Proliferation Cardiac Muscle Cell Proliferation Cell Migration Involved In Heart Development Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Endocytic Recycling
Pathways		Ubiquinol biosynthesis
Drugs
Diseases
GWAS		Regular attendance at a religious group ( 29970889)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 20062063) Liver enzyme levels (alanine transaminase) ( 33972514) Oily fish consumption ( 32066663) Pork consumption ( 32066663) QT interval ( 19305408 19305409 22726844) Schizophrenia ( 29483656)
Interacting Genes		4 interacting genes: NDRG4 PTPN9 SNX1 TTPA	37 interacting genes: AGTRAP APLNR ARFIP2 ARL6IP1 ATP5PF BCL2L13 CACFD1 CDR1 CIDEB CMTM5 COQ3 CPLX2 DERL3 DGAT2L6 ERGIC3 LEUTX LIME1 LRRC59 MAL2 MTIF3 PLP2 PRAF2 RABAC1 REEP6 RTN3 SCAMP1 SDR16C5 SFT2D2 SGK1 SIN3A SMPD2 SYNGR1 SYNGR3 SYP THAP4 TMEM208 YIF1A
Entrez ID		51805	65009
HPRD ID		07283	14817
Ensembl ID		ENSG00000132423	ENSG00000103034
Uniprot IDs		Q9NZJ6	A0A0S2Z5L7 A0A0S2Z5R7 B7Z9X4 Q9ULP0
PDB IDs
Enriched GO Terms of Interacting Partners?		Retromer, Tubulation Complex Leptin Receptor Binding Negative Regulation Of Establishment Of Blood-brain Barrier Regulation Of Establishment Of Blood-brain Barrier Vitamin E Binding Vitamin E Metabolic Process Non-membrane Spanning Protein Tyrosine Phosphatase Activity Regulation Of Cellular Localization Regulation Of Neuron Projection Development Neuron Projection Terminus Peptidyl-tyrosine Dephosphorylation Lipid Binding Transferrin Receptor Binding Early Endosome To Golgi Transport Lamellipodium Morphogenesis Retromer Complex Insulin Receptor Binding Phosphatidylinositol Bisphosphate Binding Lipid Transfer Activity Positive Regulation Of Amyloid-beta Clearance Regulation Of Amyloid-beta Clearance Regulation Of Endocytic Recycling Embryonic Heart Tube Development Cell Projection Membrane Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Cell Migration Involved In Heart Development Embryonic Placenta Development Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Synaptic Vesicle Vesicle-mediated Transport Endoplasmic Reticulum Tubular Network Formation Cytoplasmic Vesicle Endoplasmic Reticulum Tubular Network Membrane Organization Synaptic Vesicle Membrane Regulation Of Synaptic Vesicle Priming Protein Binding Regulation Of Short-term Neuronal Synaptic Plasticity Endoplasmic Reticulum Organization Synaptic Vesicle Membrane Organization Endoplasmic Reticulum Membrane Organization
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