TTF1 and AMPH

Data Source: HiPPIP (Novel)

		TTF1	AMPH
Name		transcription termination factor 1	amphiphysin
Structure		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Nucleolus	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Synaptic Vesicle Actin Cytoskeleton Membrane Synaptic Vesicle Membrane Leading Edge Membrane Cytoplasmic Vesicle Synapse
	Molecular Function	DNA Binding Chromatin Binding Protein Binding	Protein Binding Phospholipid Binding
	Biological Process	Chromatin Remodeling DNA-templated Transcription Termination Transcription By RNA Polymerase I Transcription Initiation At RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Negative Regulation Of DNA Replication	Endocytosis Chemical Synaptic Transmission Synaptic Vesicle Endocytosis
Pathways		ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression Surfactant metabolism RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Termination RNA Polymerase I Transcription Termination	Clathrin-mediated endocytosis
Diseases		Benign hereditary chorea	None
GWAS		No GWAS studies recorded	Ankylosing spondylitis ( 30946743 ) Bitter non-alcoholic beverage consumption ( 31046077 ) Cerebral microbleeds ( 31209788 ) Post bronchodilator FEV1 ( 26634245 )
Novel Interactors		3 novel interactors: AMPH QRFP WHRN	1 novel interactors: TTF1
Interacting Genes		6 interacting genes: BAZ2A CAVIN1 KAT2B NFATC3 SMAD1 SMAD7	29 interacting genes: AP2A2 ARL16 BIN1 CABIN1 CDK1 CDK5 CDK5R1 CLTC DEUP1 DNM1 DNM2 DYRK1A EGFR ITSN2 KHDRBS1 LGMN MAPK6 MAPT NECAP1 PLD2 PPP3CA PPP3CC SH3GL2 SH3GLB1 SYN1 SYNJ1 TERF1 UBC VTN
Entrez ID		7270	273
HPRD ID		02866	02687
Ensembl ID		ENSG00000125482	ENSG00000078053
Uniprot IDs		A0A087WY09 Q15361	P49418
PDB IDs		Not available	1KY7 1UTC 3SOG 4ATM 5M5S 5M61
GO Terms Enriched among Interactors		Heteromeric SMAD Protein Complex I-SMAD Binding SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Transcription Regulator Complex Ureteric Bud Development Mesonephric Epithelium Development Mesonephric Tubule Development Regulation Of Cartilage Development Negative Regulation Of Muscle Cell Differentiation Protein-containing Complex Kidney Epithelium Development Beta-catenin Destruction Complex Disassembly Positive Regulation Of Chondrocyte Hypertrophy Orexigenic Neuropeptide QRFP Receptor Binding Regulation Of MiRNA Transcription Homomeric SMAD Protein Complex Regulation Of MiRNA Metabolic Process Positive Regulation Of Chondrocyte Development DN4 Thymocyte Differentiation Negative Regulation Of RRNA Processing Histone H3K9 Acetyltransferase Activity NoRC Complex Cerebellar Purkinje Cell Layer Formation Paranodal Junction Maintenance DNA-templated Transcription Mesodermal Cell Fate Commitment Osteoblast Fate Commitment Transforming Growth Factor Beta Receptor Signaling Pathway Chromatin N-terminal Peptidyl-lysine Acetylation Diamine N-acetyltransferase Activity Stereocilia Ankle Link USH2 Complex Termination Of RNA Polymerase I Transcription RRNA Primary Transcript Binding Regulation Of Muscle Cell Differentiation Positive Regulation Of Neuron Projection Development Anti-Mullerian Hormone Receptor Signaling Pathway Activin Receptor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of RNA Biosynthetic Process Regulation Of Chondrocyte Development Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Ribosome Biogenesis L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Negative Regulation Of Ribosome Biogenesis Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose	Presynaptic Endocytosis Vesicle-mediated Transport In Synapse Presynapse Synaptic Vesicle Endocytosis Endocytosis Import Into Cell Vesicle-mediated Transport Regulation Of Cellular Component Organization Clathrin-coated Pit Receptor-mediated Endocytosis Establishment Of Localization In Cell Tau Protein Binding Vesicle Scission Regulation Of Vesicle-mediated Transport Receptor Catabolic Process Clathrin-coated Endocytic Vesicle Membrane Receptor Internalization Negative Regulation Of Macromolecule Metabolic Process Protein Kinase 5 Complex Protein Polymerization Protein Kinase Binding Positive Regulation Of Cellular Component Organization Cytosol Regulation Of Developmental Growth Negative Regulation Of Metabolic Process Identical Protein Binding Clathrin-dependent Endocytosis Positive Regulation Of Organelle Organization Positive Regulation Of Protein-containing Complex Assembly Microtubule Negative Regulation Of ERBB Signaling Pathway Clathrin Coat Disassembly Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Calmodulin-dependent Protein Phosphatase Activity Synaptic Vesicle Transport Negative Regulation Of Calcium Ion Transmembrane Transport Vesicle Uncoating Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Regulation Of DNA Replication Axon Regulation Of Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Vesicle Localization Clathrin Coat Of Coated Pit Regulation Of Growth Membrane Fission Cell Projection Organization Cytoplasmic Vesicle