TTF1 and QRFP

		TTF1	QRFP
Description		transcription termination factor 1	pyroglutamylated RFamide peptide
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Nucleolus	Extracellular Region
	Molecular Function	DNA Binding Chromatin Binding Protein Binding	G Protein-coupled Receptor Binding Signaling Receptor Binding Neuropeptide Hormone Activity Orexigenic Neuropeptide QRFP Receptor Binding
	Biological Process	Chromatin Remodeling DNA-templated Transcription Termination Transcription By RNA Polymerase I Transcription Initiation At RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Negative Regulation Of DNA Replication	Neuropeptide Signaling Pathway Grooming Behavior Locomotory Behavior Positive Regulation Of Blood Pressure Regulation Of Feeding Behavior
Pathways		ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression Surfactant metabolism RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Termination RNA Polymerase I Transcription Termination	Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events
Drugs
Diseases		Benign hereditary chorea
GWAS
Interacting Genes		6 interacting genes: BAZ2A CAVIN1 KAT2B NFATC3 SMAD1 SMAD7
Entrez ID		7270	347148
HPRD ID		02866	17813
Ensembl ID		ENSG00000125482	ENSG00000188710
Uniprot IDs		A0A087WY09 Q15361	P83859
PDB IDs			8ZH8
Enriched GO Terms of Interacting Partners?		Heteromeric SMAD Protein Complex I-SMAD Binding SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Transcription Regulator Complex Ureteric Bud Development Mesonephric Epithelium Development Mesonephric Tubule Development Regulation Of Cartilage Development Negative Regulation Of Muscle Cell Differentiation Protein-containing Complex Kidney Epithelium Development Beta-catenin Destruction Complex Disassembly Positive Regulation Of Chondrocyte Hypertrophy Orexigenic Neuropeptide QRFP Receptor Binding Regulation Of MiRNA Transcription Homomeric SMAD Protein Complex Regulation Of MiRNA Metabolic Process Positive Regulation Of Chondrocyte Development DN4 Thymocyte Differentiation Negative Regulation Of RRNA Processing Histone H3K9 Acetyltransferase Activity NoRC Complex Cerebellar Purkinje Cell Layer Formation Paranodal Junction Maintenance DNA-templated Transcription Mesodermal Cell Fate Commitment Osteoblast Fate Commitment Transforming Growth Factor Beta Receptor Signaling Pathway Chromatin N-terminal Peptidyl-lysine Acetylation Diamine N-acetyltransferase Activity Stereocilia Ankle Link USH2 Complex Termination Of RNA Polymerase I Transcription RRNA Primary Transcript Binding Regulation Of Muscle Cell Differentiation Positive Regulation Of Neuron Projection Development Anti-Mullerian Hormone Receptor Signaling Pathway Activin Receptor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of RNA Biosynthetic Process Regulation Of Chondrocyte Development Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Ribosome Biogenesis L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Negative Regulation Of Ribosome Biogenesis Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose	Termination Of RNA Polymerase I Transcription Transcription Initiation At RNA Polymerase I Promoter Transcription By RNA Polymerase I DNA-templated Transcription Termination Negative Regulation Of DNA Replication DNA-templated Transcription Initiation Regulation Of DNA Replication Negative Regulation Of DNA Metabolic Process Fibrillar Center
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