TMEFF2 and TRHR

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEFF2	TRHR
Description		transmembrane protein with EGF like and two follistatin like domains 2	thyrotropin releasing hormone receptor
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Membrane	Plasma Membrane Membrane
	Molecular Function	Protein Binding	G Protein-coupled Receptor Activity Thyrotropin-releasing Hormone Receptor Activity Protein Binding
	Biological Process	Response To Stress Cell Differentiation Negative Regulation Of Cell Migration Wound Healing, Spreading Of Cells Negative Regulation Of Integrin Biosynthetic Process Negative Regulation Of Stress Fiber Assembly	Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Pathways			Peptide ligand-binding receptors G alpha (q) signalling events
Drugs			Protirelin
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Adverse response to drug ( 30420678) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Diabetes (incident) ( 17903298) Schizophrenia ( 33169155) Sudden cardiac arrest ( 21658281)	Body mass (lean) ( 19268274) Daytime sleep phenotypes ( 27126917) LDL cholesterol levels ( 32203549) Night sleep phenotypes ( 27126917) Pulse pressure ( 30224653) Type 2 diabetes ( 30297969)
Interacting Genes		10 interacting genes: DRD2 HSF2BP HTR4 NBPF19 NOTCH2NLA RIC3 TMEM237 TRHR UBIAD1 ZDHHC15	19 interacting genes: ARRB1 C1QL4 COMT EFNA5 FAM241B FXYD6-FXYD2 GJB2 IER3IP1 NIPAL4 PEDS1-UBE2V1 SLC39A2 SLC39A9 SLC41A1 TMEFF2 TMEM218 TMEM239 TRH UBE2J1 YIPF6
Entrez ID		23671	7201
HPRD ID		05760	11767
Ensembl ID		ENSG00000144339	ENSG00000174417
Uniprot IDs		Q9UIK5	P34981
PDB IDs			7WKD 7X1T 7X1U 7XW9
Enriched GO Terms of Interacting Partners?			Magnesium Ion Transport Magnesium Ion Transmembrane Transport Magnesium Ion Transmembrane Transporter Activity Zinc Ion Transport Zinc Ion Transmembrane Transporter Activity Metal Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transport
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