CLDN5 and MPDZ

Number of citations of the paper that reports this interaction (PubMedID 12403818)
72

Data Source:
HPRD (in vivo)

		CLDN5	MPDZ
Description		claudin 5	multiple PDZ domain crumbs cell polarity complex component
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Cell Junction Cortical Actin Cytoskeleton Paranode Region Of Axon Schmidt-Lanterman Incisure Tight Junction Anchoring Junction	Cytoplasm Plasma Membrane Bicellular Tight Junction Postsynaptic Density Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Dendrite Cell Projection Neuron Projection Apical Part Of Cell Synapse Anchoring Junction
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Outflow Tract Morphogenesis Cell-cell Junction Assembly Cell Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Learning Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Negative Regulation Of Angiogenesis Negative Regulation Of Cell Migration Maintenance Of Blood-brain Barrier Myelination Negative Regulation Of Vascular Permeability Response To Ethanol Roof Of Mouth Development Face Morphogenesis Bicellular Tight Junction Assembly Tight Junction Assembly Positive Regulation Of Establishment Of Endothelial Barrier Positive Regulation Of Bicellular Tight Junction Assembly Establishment Of Blood-retinal Barrier	Tight Junction Assembly
Pathways		Tight junction interactions RUNX1 regulates expression of components of tight junctions
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Central corneal thickness ( 29760442 32528159) Corneal hysteresis ( 30894546 32716492) Corneal structure ( 23291589) Heel bone mineral density ( 28869591 30598549) Refractive astigmatism ( 30306274) Triglyceride levels ( 32203549)
Interacting Genes		40 interacting genes: AQP1 BTNL8 CCDC167 CLDN3 CLRN2 CNPY3 CORIN CTRL CXCL9 CYB561A3 EFNA5 EHHADH ERG28 ERMP1 FXYD6-FXYD2 GYPA LAT LHFPL5 MIP MPDZ PLP2 PLPPR2 PMP22 RPRM SFTPC SGCG SLC35B4 SMIM3 TECR TF TJP1 TMEM128 TMEM140 TMEM14C TMEM182 TMEM190 TMEM222 TSPAN2 VAMP5 YIPF1	19 interacting genes: ABCA1 CAMK2A CCDC88C CLDN1 CLDN5 CRHR1 CSPG4 DRD3 F11R HTR2C KIT MTNR1A PELI2 PLEKHA1 PLEKHA2 RNF5 SYNGAP1 TSC22D2 VANGL2
Entrez ID		7122	8777
HPRD ID		03654	09155
Ensembl ID		ENSG00000184113	ENSG00000107186
Uniprot IDs		D3DX19 O00501	O75970
PDB IDs			2FCF 2FNE 2IWN 2IWO 2IWP 2IWQ 2O2T 2OPG 2QG1
Enriched GO Terms of Interacting Partners?		Membrane	Regulation Of Biological Quality Plasma Membrane Cell-cell Junction Regulation Of Bicellular Tight Junction Assembly PDZ Domain Binding Regulation Of Cell Communication Regulation Of Signaling Maintenance Of Blood-brain Barrier Tight Junction Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Establishment Of Endothelial Barrier Learning Visual Learning Regulation Of Neuronal Synaptic Plasticity Visual Behavior Regulation Of MAPK Cascade Positive Regulation Of Bicellular Tight Junction Assembly Lateral Plasma Membrane Cell Junction Signal Transduction Regulation Of Cellular Component Organization Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Establishment Of Endothelial Intestinal Barrier G Protein-coupled Receptor Signaling Pathway Associative Learning Response To Alcohol Positive Regulation Of Signal Transduction Regulation Of Establishment Of Endothelial Barrier Learning Or Memory Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Plasma Membrane Bounded Cell Projection Organization Response To Ethanol Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Phosphate Metabolic Process Ruffle Organization Cognition Bicellular Tight Junction Regulation Of Long-term Neuronal Synaptic Plasticity Phosphatidylinositol-3,4-bisphosphate Binding Face Morphogenesis Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Platelet-derived Growth Factor Receptor Signaling Pathway Response To Stress
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?