CLDN5 and TSPAN2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLDN5	TSPAN2
Description		claudin 5	tetraspanin 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Cell Junction Cortical Actin Cytoskeleton Paranode Region Of Axon Schmidt-Lanterman Incisure Tight Junction Anchoring Junction	Nucleoplasm Plasma Membrane Membrane Myelin Sheath
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Outflow Tract Morphogenesis Cell-cell Junction Assembly Cell Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Learning Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Negative Regulation Of Angiogenesis Negative Regulation Of Cell Migration Maintenance Of Blood-brain Barrier Myelination Negative Regulation Of Vascular Permeability Response To Ethanol Roof Of Mouth Development Face Morphogenesis Bicellular Tight Junction Assembly Tight Junction Assembly Positive Regulation Of Establishment Of Endothelial Barrier Positive Regulation Of Bicellular Tight Junction Assembly Establishment Of Blood-retinal Barrier	Inflammatory Response Astrocyte Development Microglia Development Myelination Oligodendrocyte Differentiation Axon Development
Pathways		Tight junction interactions RUNX1 regulates expression of components of tight junctions
Drugs
Diseases
GWAS			Dysmenorrheic pain ( 27454463) Ischemic stroke (large artery atherosclerosis) ( 26708676) Large artery stroke (CCS and TOAST classification) ( 32047268) Large artery stroke (CCS or TOAST classification) ( 32047268) Large artery stroke (CCSp classification)j ( 32047268) Migraine ( 23793025 27182965 27322543) Migraine without aura ( 23793025 27322543) Mild obesity-related type 2 diabetes ( 34737425)
Interacting Genes		40 interacting genes: AQP1 BTNL8 CCDC167 CLDN3 CLRN2 CNPY3 CORIN CTRL CXCL9 CYB561A3 EFNA5 EHHADH ERG28 ERMP1 FXYD6-FXYD2 GYPA LAT LHFPL5 MIP MPDZ PLP2 PLPPR2 PMP22 RPRM SFTPC SGCG SLC35B4 SMIM3 TECR TF TJP1 TMEM128 TMEM140 TMEM14C TMEM182 TMEM190 TMEM222 TSPAN2 VAMP5 YIPF1	35 interacting genes: ABHD16A ATP1B4 BSCL2 CD79A CLDN5 CLEC14A CREB3 CREB3L1 DCBLD2 FAM209A FKBP7 FOS GRB2 IFNGR2 KDELR3 LEPROTL1 LMNA MFF MGST3 PGRMC2 PIK3R3 RABGAP1L REEP4 RNF19B SCN3B SLC10A6 SLC30A8 SLC35H1 TMEM130 TMEM14B TMEM31 TMX2 TSPAN31 VSIR ZFYVE27
Entrez ID		7122	10100
HPRD ID		03654	18233
Ensembl ID		ENSG00000184113	ENSG00000134198
Uniprot IDs		D3DX19 O00501	B1AKP1 B2RD31 O60636
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane	Membrane Endoplasmic Reticulum Identical Protein Binding Endoplasmic Reticulum Membrane Protein Binding
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