CLDN5 and CLDN3

Number of citations of the paper that reports this interaction (PubMedID 12909588)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		CLDN5	CLDN3
Description		claudin 5	claudin 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Cell Junction Cortical Actin Cytoskeleton Paranode Region Of Axon Schmidt-Lanterman Incisure Tight Junction Anchoring Junction	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Protein-containing Complex Apical Junction Complex Tight Junction Anchoring Junction
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding	Transmembrane Signaling Receptor Activity Structural Molecule Activity Protein Binding Identical Protein Binding Cell-cell Adhesion Mediator Activity
	Biological Process	Outflow Tract Morphogenesis Cell-cell Junction Assembly Cell Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Learning Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Negative Regulation Of Angiogenesis Negative Regulation Of Cell Migration Maintenance Of Blood-brain Barrier Myelination Negative Regulation Of Vascular Permeability Response To Ethanol Roof Of Mouth Development Face Morphogenesis Bicellular Tight Junction Assembly Tight Junction Assembly Positive Regulation Of Establishment Of Endothelial Barrier Positive Regulation Of Bicellular Tight Junction Assembly Establishment Of Blood-retinal Barrier	Response To Hypoxia Epithelial Cell Morphogenesis Retinal Pigment Epithelium Development Cell Adhesion Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Establishment Of Endothelial Blood-brain Barrier Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Regulation Of Cell Morphogenesis Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Cell Junction Assembly Cell Junction Maintenance Maintenance Of Blood-brain Barrier Cell-cell Junction Maintenance Response To Ethanol Bicellular Tight Junction Assembly Positive Regulation Of Wound Healing Regulation Of Membrane Permeability Response To Gram-positive Bacterium Regulation Of Transepithelial Transport Negative Regulation Of Phosphate Transmembrane Transport
Pathways		Tight junction interactions RUNX1 regulates expression of components of tight junctions	Tight junction interactions
Drugs
Diseases
GWAS			Mean platelet volume ( 27863252) Platelet distribution width ( 27863252)
Interacting Genes		40 interacting genes: AQP1 BTNL8 CCDC167 CLDN3 CLRN2 CNPY3 CORIN CTRL CXCL9 CYB561A3 EFNA5 EHHADH ERG28 ERMP1 FXYD6-FXYD2 GYPA LAT LHFPL5 MIP MPDZ PLP2 PLPPR2 PMP22 RPRM SFTPC SGCG SLC35B4 SMIM3 TECR TF TJP1 TMEM128 TMEM140 TMEM14C TMEM182 TMEM190 TMEM222 TSPAN2 VAMP5 YIPF1	7 interacting genes: APP CLDN1 CLDN5 POM121 PRKACA TJP1 WNK4
Entrez ID		7122	1365
HPRD ID		03654	04219
Ensembl ID		ENSG00000184113	ENSG00000165215
Uniprot IDs		D3DX19 O00501	O15551 Q75L79
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane	Regulation Of Bicellular Tight Junction Assembly Regulation Of Cell Junction Assembly Bicellular Tight Junction Maintenance Of Blood-brain Barrier Tight Junction Multicellular Organismal-level Homeostasis Homeostatic Process Positive Regulation Of Bicellular Tight Junction Assembly Cell Adhesion Establishment Of Endothelial Intestinal Barrier Cell-cell Junction Assembly Anchoring Junction Response To Lead Ion Cell Junction Organization Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cell-cell Junction Organization Anatomical Structure Homeostasis Tissue Homeostasis Cell Junction Establishment Of Endothelial Barrier Endothelial Cell Development System Process Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Vascular Permeability Cell Junction Assembly Bicellular Tight Junction Assembly Regulation Of Glycolytic Process Regulation Of Monoatomic Ion Transmembrane Transport Protein-containing Complex Cell Junction Maintenance Tight Junction Assembly Tight Junction Organization Positive Regulation Of Calcium-mediated Signaling Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Macrophage Activation Amylin Binding Positive Regulation Of Toll Signaling Pathway Cell Development Regulation Of Metal Ion Transport Cellular Component Maintenance Lateral Plasma Membrane Xenobiotic Transport Across Blood-nerve Barrier Aldosterone Secretion Regulation Of ATP Metabolic Process Membrane Regulation Of Cell Migration Cell Body
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