TLR1 and HSP90B1

Number of citations of the paper that reports this interaction (PubMedID 11584270)
0

Data Source:
HPRD (in vivo)

		TLR1	HSP90B1
Description		toll like receptor 1	heat shock protein 90 beta family member 1
Image
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Receptor Complex Membrane Raft	Extracellular Region Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Cytosol Focal Adhesion Membrane Sarcoplasmic Reticulum Midbody Protein-containing Complex Sarcoplasmic Reticulum Lumen Endoplasmic Reticulum Chaperone Complex Melanosome Perinuclear Region Of Cytoplasm Extracellular Exosome Endocytic Vesicle Lumen Sperm Plasma Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Toll-like Receptor 2 Binding Signaling Receptor Activity Identical Protein Binding NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Lipopeptide Binding	Nucleotide Binding RNA Binding Protein Phosphatase Inhibitor Activity Calcium Ion Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein Phosphatase Binding Protein Folding Chaperone Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Microglial Cell Activation Toll-like Receptor Signaling Pathway Immune System Process Defense Response Inflammatory Response Immune Response Signal Transduction Response To Bacterial Lipoprotein Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Macrophage Activation Detection Of Triacyl Bacterial Lipopeptide Innate Immune Response Cellular Response To Triacyl Bacterial Lipopeptide	Response To Hypoxia Protein Folding Protein Transport Positive Regulation Of Wnt Signaling Pathway Retrograde Protein Transport, ER To Cytosol Actin Rod Assembly Positive Regulation Of Toll-like Receptor Signaling Pathway Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress ERAD Pathway Negative Regulation Of Apoptotic Process Sequestering Of Calcium Ion Cellular Response To Manganese Ion Cellular Response To ATP Protein Localization To Plasma Membrane
Pathways		ER-Phagosome pathway Beta defensins MyD88:MAL(TIRAP) cascade initiated on plasma membrane Toll Like Receptor TLR1:TLR2 Cascade MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand SARS-CoV-2 activates/modulates innate and adaptive immune responses	Trafficking and processing of endosomal TLR Scavenging by Class A Receptors Scavenging by Class A Receptors ATF6 (ATF6-alpha) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-4 and Interleukin-13 signaling Post-translational protein phosphorylation
Drugs			Rifabutin 2-Chlorodideoxyadenosine Geldanamycin Diglyme N-Ethyl-5'-Carboxamido Adenosine Radicicol METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE Copper
Diseases
GWAS		Alcohol consumption ( 23743675) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406) Allergic rhinitis ( 30013184 31361310) Allergic sensitization ( 23817571 30013184) Allergy ( 27182965) Asthma ( 34103634 27182965 32296059 31959851 31619474 30929738 31361310) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 30929738 31036433) Asthma and hay fever ( 24388013) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Composite immunoglobulin trait (IgG/IgM) ( 28628107) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) ( 27670767) Helicobacter pylori serologic status ( 23652523) Self-reported allergy ( 23817569) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537)	Metabolite levels ( 23823483) Soluble VCAM-1 levels ( 31217265)
Interacting Genes		9 interacting genes: DHX36 HSP90B1 HSPD1 TLR10 TLR2 TLR4 TLR5 TLR9 TRAP1	40 interacting genes: APOB ASGR1 BIRC2 CACYBP CAMLG CSNK2A1 CSNK2A2 CYSLTR2 EGFR ERBB2 ESR1 FANCC GPR37 GRIK1 HSPA13 HSPA9 LINC01554 LRP1 MAPK6 MDM2 MTTP NKX3-1 NR5A2 OGT POLR2E PTEN PTPN11 PVT1 RNF10 RXFP3 SGTB SIRPA SUPT6H TG TLR1 TLR2 TLR4 TP53 TXNDC11 UBASH3A
Entrez ID		7096	7184
HPRD ID		03119	01860
Ensembl ID		ENSG00000174125	ENSG00000166598
Uniprot IDs		Q15399	P14625 V9HWP2
PDB IDs		1FYV 2Z7X 6NIH 7NT7 7NUW 7NUX	4NH9 7ULL
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Innate Immune Response Activation Of Innate Immune Response Positive Regulation Of Defense Response Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Immune System Process Regulation Of Type I Interferon Production Positive Regulation Of Immune Response Positive Regulation Of Interleukin-12 Production Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Defense Response Positive Regulation Of Interleukin-8 Production Cellular Response To Molecule Of Bacterial Origin Regulation Of Interleukin-12 Production Detection Of Molecule Of Bacterial Origin Regulation Of Immune System Process NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Positive Regulation Of Cytokine Production Regulation Of Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Dendritic Cell Cytokine Production Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-6 Production Innate Immune Response Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Response To Molecule Of Bacterial Origin Detection Of Biotic Stimulus Defense Response To Symbiont Defense Response To Other Organism ATP-dependent Protein Folding Chaperone Lipopolysaccharide Binding Positive Regulation Of Matrix Metallopeptidase Secretion Regulation Of Interleukin-6 Production Regulation Of Cytokine Production Pattern Recognition Receptor Activity Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-10 Production Cellular Response To Oxygen-containing Compound Cell Surface Toll-like Receptor Signaling Pathway Lipopolysaccharide Receptor Complex Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Interferon-beta Production Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Transmembrane Signaling Receptor Activity	Receptor Complex Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Developmental Process Negative Regulation Of Proteolysis Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Metabolic Process Rhythmic Process Negative Regulation Of Developmental Process Negative Regulation Of Multicellular Organismal Process Animal Organ Development Heart Development Detection Of Molecule Of Bacterial Origin Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxygen-containing Compound Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Detection Of Triacyl Bacterial Lipopeptide Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Negative Regulation Of Cell Communication Negative Regulation Of Signaling Ubiquitin Protein Ligase Binding Regulation Of Intracellular Signal Transduction Lipoprotein Transport Intracellular Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Protein Catabolic Process Regulation Of Interferon-beta Production Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase CK2 Complex Cellular Response To Actinomycin D Cellular Response To Triacyl Bacterial Lipopeptide Positive Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Regulation Of Protein Catabolic Process Negative Regulation Of Cell Differentiation Regulation Of Signal Transduction Response To Actinomycin D Detection Of Bacterial Lipoprotein Regulation Of Proteolysis ERBB Signaling Pathway Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Identical Protein Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?