TLR1 and DHX36

Number of citations of the paper that reports this interaction (PubMedID 16482509)
45

Data Source:
HPRD (two hybrid)

		TLR1	DHX36
Description		toll like receptor 1	DEAH-box helicase 36
Image
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Receptor Complex Membrane Raft	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Cytoplasm Mitochondrion Cytosol Cytoplasmic Stress Granule Nuclear Speck Axon Dendrite Cell Projection Perikaryon Extracellular Exosome
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Toll-like Receptor 2 Binding Signaling Receptor Activity Identical Protein Binding NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Lipopeptide Binding	Nucleotide Binding Magnesium Ion Binding Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding G-quadruplex RNA Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity Single-stranded DNA Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding MRNA 3'-UTR Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity MRNA 3'-UTR AU-rich Region Binding Histone Deacetylase Binding Metal Ion Binding MRNA 5'-UTR Binding G-quadruplex DNA Binding Telomerase RNA Binding Pre-miRNA Binding Catalytic Activity, Acting On A Nucleic Acid
	Biological Process	Microglial Cell Activation Toll-like Receptor Signaling Pathway Immune System Process Defense Response Inflammatory Response Immune Response Signal Transduction Response To Bacterial Lipoprotein Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Macrophage Activation Detection Of Triacyl Bacterial Lipopeptide Innate Immune Response Cellular Response To Triacyl Bacterial Lipopeptide	Ossification Immune System Process Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Regulation Of Transcription By RNA Polymerase III Regulation Of Translation Spermatogenesis Response To Virus Positive Regulation Of Gene Expression Negative Regulation Of Translation Cell Differentiation Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Telomere Maintenance Positive Regulation Of Interferon-alpha Production Cellular Response To Heat Cellular Response To UV Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Exogenous DsRNA Regulation Of MRNA Stability Innate Immune Response Positive Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Defense Response To Virus Positive Regulation Of Cardioblast Differentiation Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Dendritic Spine Morphogenesis 3'-UTR-mediated MRNA Destabilization Telomerase RNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Cellular Response To Arsenite Ion Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Intracellular MRNA Localization Positive Regulation Of Cytoplasmic Translation
Pathways		ER-Phagosome pathway Beta defensins MyD88:MAL(TIRAP) cascade initiated on plasma membrane Toll Like Receptor TLR1:TLR2 Cascade MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand SARS-CoV-2 activates/modulates innate and adaptive immune responses	DEx/H-box helicases activate type I IFN and inflammatory cytokines production
Drugs
Diseases
GWAS		Alcohol consumption ( 23743675) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406) Allergic rhinitis ( 30013184 31361310) Allergic sensitization ( 23817571 30013184) Allergy ( 27182965) Asthma ( 34103634 27182965 32296059 31959851 31619474 30929738 31361310) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 30929738 31036433) Asthma and hay fever ( 24388013) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Composite immunoglobulin trait (IgG/IgM) ( 28628107) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) ( 27670767) Helicobacter pylori serologic status ( 23652523) Self-reported allergy ( 23817569) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537)	Body mass index ( 29273807) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		9 interacting genes: DHX36 HSP90B1 HSPD1 TLR10 TLR2 TLR4 TLR5 TLR9 TRAP1	72 interacting genes: DUX4 IL7R MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F2 MIRLET7G MIRLET7I RNF10 TLR1 ZFP36
Entrez ID		7096	170506
HPRD ID		03119	09918
Ensembl ID		ENSG00000174125	ENSG00000174953
Uniprot IDs		Q15399	Q9H2U1
PDB IDs		1FYV 2Z7X 6NIH 7NT7 7NUW 7NUX	2N16 2N21 6Q6R
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Innate Immune Response Activation Of Innate Immune Response Positive Regulation Of Defense Response Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Immune System Process Regulation Of Type I Interferon Production Positive Regulation Of Immune Response Positive Regulation Of Interleukin-12 Production Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Defense Response Positive Regulation Of Interleukin-8 Production Cellular Response To Molecule Of Bacterial Origin Regulation Of Interleukin-12 Production Detection Of Molecule Of Bacterial Origin Regulation Of Immune System Process NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Positive Regulation Of Cytokine Production Regulation Of Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Dendritic Cell Cytokine Production Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-6 Production Innate Immune Response Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Response To Molecule Of Bacterial Origin Detection Of Biotic Stimulus Defense Response To Symbiont Defense Response To Other Organism ATP-dependent Protein Folding Chaperone Lipopolysaccharide Binding Positive Regulation Of Matrix Metallopeptidase Secretion Regulation Of Interleukin-6 Production Regulation Of Cytokine Production Pattern Recognition Receptor Activity Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-10 Production Cellular Response To Oxygen-containing Compound Cell Surface Toll-like Receptor Signaling Pathway Lipopolysaccharide Receptor Complex Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Interferon-beta Production Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Transmembrane Signaling Receptor Activity	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Angiogenesis Negative Regulation Of Cell Migration Regulation Of Vasculature Development Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Regulation Of Metabolic Process Negative Regulation Of Locomotion Regulation Of Translation Regulation Of MRNA Stability Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Developmental Process Regulation Of RNA Stability Negative Regulation Of Protein Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Endothelial Cell Migration Extracellular Space Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Regulation Of MRNA Metabolic Process Regulation Of Cytokine Production Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Anatomical Structure Morphogenesis
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