TLR1 and TLR9

Number of citations of the paper that reports this interaction (PMID 12600829)
11

Data Source:
HPRD (in vitro)

		TLR1	TLR9
Gene Name		toll-like receptor 1	toll-like receptor 9
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Phagocytic Vesicle Membrane Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex	Golgi Membrane Extracellular Region Cytoplasm Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Endosome Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Early Phagosome Endolysosome Membrane
	Molecular Function	Receptor Activity Transmembrane Signaling Receptor Activity Protein Heterodimerization Activity	Transmembrane Signaling Receptor Activity Interleukin-1 Receptor Binding SiRNA Binding
	Biological Process	MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response Signal Transduction Toll-like Receptor 1 Signaling Pathway Macrophage Activation Detection Of Triacyl Bacterial Lipopeptide Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Innate Immune Response Positive Regulation Of Interleukin-6 Biosynthetic Process Regulation Of Cytokine Secretion Cellular Response To Triacyl Bacterial Lipopeptide	Toll-like Receptor Signaling Pathway Response To Molecule Of Bacterial Origin MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response I-kappaB Phosphorylation Insulin Receptor Signaling Pathway Maintenance Of Gastrointestinal Epithelium Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of NF-kappaB Import Into Nucleus Defense Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JUN Kinase Activity Positive Regulation Of Interferon-gamma Biosynthetic Process Innate Immune Response Positive Regulation Of Interferon-alpha Biosynthetic Process Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Regulation Of Cytokine Secretion Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Pathways			Insulin receptor signalling cascade IRS-mediated signalling Toll Like Receptor 7/8 (TLR7/8) Cascade IRS-related events IGF1R signaling cascade IRS-related events triggered by IGF1R Trafficking and processing of endosomal TLR Toll-Like Receptors Cascades IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Toll Like Receptor 9 (TLR9) Cascade PI3K Cascade PI3K Cascade Innate Immune System Signaling by Insulin receptor
Drugs			Chloroquine Hydroxychloroquine
Diseases
GWAS		Alcohol consumption ( 23743675) Helicobacter pylori serologic status ( 23652523)	Bipolar disorder ( 21926972)
Protein-Protein Interactions		9 interactors: DHX36 HSP90B1 HSPD1 TLR10 TLR2 TLR4 TLR5 TLR9 TRAP1	6 interactors: BTK HRAS MAPK8IP3 RNF216 SIGIRR TLR1
Entrez ID		7096	54106
HPRD ID		03119	05685
Ensembl ID		ENSG00000174125	ENSG00000239732
Uniprot IDs		Q15399 Q32MK4	Q9NR96
PDB IDs		1FYV 2Z7X
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of Type I Interferon Production Immune Response-regulating Signaling Pathway Regulation Of Cytokine Production Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Immune Response Regulation Of Cytokine Secretion Immune Response Positive Regulation Of Cytokine Production Positive Regulation Of Interleukin-12 Production Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process I-kappaB Phosphorylation Positive Regulation Of Inflammatory Response Positive Regulation Of Interferon-alpha Production Response To Stress Immune System Process Regulation Of Interleukin-6 Production Regulation Of Immune System Process Positive Regulation Of NF-kappaB Import Into Nucleus Defense Response Positive Regulation Of Interferon-beta Production Regulation Of Protein Secretion Regulation Of Reactive Oxygen Species Metabolic Process Inflammatory Response Positive Regulation Of Interleukin-18 Production Positive Regulation Of Transcription Factor Import Into Nucleus Regulation Of Interferon-beta Production Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Chemokine Production Defense Response To Bacterium Positive Regulation Of Interferon-gamma Production Regulation Of Chemokine Production	Regulation Of Cytokine Production Inflammatory Response Lung Morphogenesis Regulation Of Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Defense Response Immune Response-regulating Signaling Pathway Toll-like Receptor 1 Signaling Pathway Regulation Of B Cell Cytokine Production Regulation Of Cytokine Biosynthetic Process Toll-like Receptor Signaling Pathway Response To Stress Positive Regulation Of JNK Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Response To External Stimulus Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Cellular Response To Molecule Of Fungal Origin Detection Of Triacyl Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide Activation Of Innate Immune Response Regulation Of JNK Cascade Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Immune Response Regulation Of Stress-activated MAPK Cascade Regulation Of Protein Metabolic Process Response To Molecule Of Fungal Origin Positive Regulation Of MAP Kinase Activity Positive Regulation Of Rac Protein Signal Transduction Negative Regulation Of Chemokine Biosynthetic Process Apoptotic Process Fc-epsilon Receptor Signaling Pathway MAPK Cascade Programmed Cell Death Positive Regulation Of MiRNA Metabolic Process Regulation Of Innate Immune Response Cell Death Death Positive Regulation Of Ruffle Assembly Detection Of Bacterial Lipoprotein Lung Development Respiratory Tube Development Fc Receptor Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation Respiratory System Development Regulation Of MAP Kinase Activity
Tagcloud ?		bed cd14 constitutively fibroblast immunoassay immunocytochemistry lamina lipopolysaccharide lps md measuring microorganisms nucleus p65 polyp propria quantified respond responsiveness scar strategic supernatant tlr4 tlr9 tlrs toll vff vffs vocal	bed cd14 constitutively fibroblast immunoassay immunocytochemistry lamina lipopolysaccharide lps md measuring microorganisms nucleus p65 polyp propria quantified respond responsiveness scar strategic supernatant tlr1 tlr4 tlrs toll vff vffs vocal
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		bed cd14 constitutively fibroblast immunoassay immunocytochemistry lamina lipopolysaccharide lps md measuring microorganisms nucleus p65 polyp propria quantified respond responsiveness scar strategic supernatant tlr1 tlr4 tlr9 tlrs toll vff vffs vocal