TLR1 and TLR9

Number of citations of the paper that reports this interaction (PubMedID 12600829)
0

Data Source:
HPRD (in vitro)

		TLR1	TLR9
Description		toll like receptor 1	toll like receptor 9
Image
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Receptor Complex Membrane Raft	Golgi Membrane Extracellular Region Cytoplasm Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Endosome Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Cytoplasmic Vesicle Early Endosome Membrane Early Phagosome Endolysosome Endolysosome Membrane Phagocytic Vesicle
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Toll-like Receptor 2 Binding Signaling Receptor Activity Identical Protein Binding NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Lipopeptide Binding	Interleukin-1 Receptor Binding SiRNA Binding Pattern Recognition Receptor Activity Protein Homodimerization Activity Unmethylated CpG Binding
	Biological Process	Microglial Cell Activation Toll-like Receptor Signaling Pathway Immune System Process Defense Response Inflammatory Response Immune Response Signal Transduction Response To Bacterial Lipoprotein Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Macrophage Activation Detection Of Triacyl Bacterial Lipopeptide Innate Immune Response Cellular Response To Triacyl Bacterial Lipopeptide	Microglial Cell Activation Positive Regulation Of Cytokine Production Activation Of Innate Immune Response Toll-like Receptor Signaling Pathway Immune System Process Positive Regulation Of Immunoglobulin Production Regulation Of Dendritic Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response Signal Transduction Canonical NF-kappaB Signal Transduction Male Gonad Development Response To Virus Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Maintenance Of Gastrointestinal Epithelium Positive Regulation Of B Cell Proliferation Positive Regulation Of Type I Interferon Production Detection Of Molecule Of Bacterial Origin Positive Regulation Of Chemokine Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Innate Immune Response Regulation Of B Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Regulation Of B Cell Activation Positive Regulation Of B Cell Activation Defense Response To Virus Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Metal Ion Defense Response To Other Organism Endolysosomal Toll-like Receptor Signaling Pathway Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Cellular Response To Chloroquine Positive Regulation Of Intestinal Epithelial Cell Development
Pathways		ER-Phagosome pathway Beta defensins MyD88:MAL(TIRAP) cascade initiated on plasma membrane Toll Like Receptor TLR1:TLR2 Cascade MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand SARS-CoV-2 activates/modulates innate and adaptive immune responses	PI3K Cascade Trafficking and processing of endosomal TLR Toll Like Receptor 9 (TLR9) Cascade Potential therapeutics for SARS TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome
Drugs			Chloroquine Hydroxychloroquine ISS-1018 Golotimod CPG 10101 Tilsotolimod
Diseases
GWAS		Alcohol consumption ( 23743675) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406) Allergic rhinitis ( 30013184 31361310) Allergic sensitization ( 23817571 30013184) Allergy ( 27182965) Asthma ( 34103634 27182965 32296059 31959851 31619474 30929738 31361310) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 30929738 31036433) Asthma and hay fever ( 24388013) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Composite immunoglobulin trait (IgG/IgM) ( 28628107) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) ( 27670767) Helicobacter pylori serologic status ( 23652523) Self-reported allergy ( 23817569) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537)	A body shape index ( 34021172) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Colon cancer ( 33632709) Distal colorectal cancer ( 33632709) Feeling nervous ( 29500382) General cognitive ability ( 29844566) Parkinson's disease ( 28892059) Schizophrenia ( 23974872) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		9 interacting genes: DHX36 HSP90B1 HSPD1 TLR10 TLR2 TLR4 TLR5 TLR9 TRAP1	6 interacting genes: BTK HRAS MAPK8IP3 RNF216 SIGIRR TLR1
Entrez ID		7096	54106
HPRD ID		03119	05685
Ensembl ID		ENSG00000174125	ENSG00000239732
Uniprot IDs		Q15399	Q9NR96
PDB IDs		1FYV 2Z7X 6NIH 7NT7 7NUW 7NUX	8AR3
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Innate Immune Response Activation Of Innate Immune Response Positive Regulation Of Defense Response Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Immune System Process Regulation Of Type I Interferon Production Positive Regulation Of Immune Response Positive Regulation Of Interleukin-12 Production Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Defense Response Positive Regulation Of Interleukin-8 Production Cellular Response To Molecule Of Bacterial Origin Regulation Of Interleukin-12 Production Detection Of Molecule Of Bacterial Origin Regulation Of Immune System Process NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Positive Regulation Of Cytokine Production Regulation Of Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Dendritic Cell Cytokine Production Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-6 Production Innate Immune Response Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Response To Molecule Of Bacterial Origin Detection Of Biotic Stimulus Defense Response To Symbiont Defense Response To Other Organism ATP-dependent Protein Folding Chaperone Lipopolysaccharide Binding Positive Regulation Of Matrix Metallopeptidase Secretion Regulation Of Interleukin-6 Production Regulation Of Cytokine Production Pattern Recognition Receptor Activity Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-10 Production Cellular Response To Oxygen-containing Compound Cell Surface Toll-like Receptor Signaling Pathway Lipopolysaccharide Receptor Complex Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Interferon-beta Production Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Transmembrane Signaling Receptor Activity	Regulation Of Cytokine Production Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Regulation Of B Cell Cytokine Production Monocyte Proliferation Positive Regulation Of Interleukin-17A Production Negative Regulation Of Gene Expression Immune Response-regulating Signaling Pathway Cytoplasmic Vesicle Activation Of Immune Response Toll-like Receptor Signaling Pathway Negative Regulation Of Cytokine Production Immune Response-activating Signaling Pathway Positive Regulation Of Type I Hypersensitivity Positive Regulation Of Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6 Production Defense Response T Cell Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production B Cell Affinity Maturation Positive Regulation Of JNK Cascade GTPase Complex Detection Of Triacyl Bacterial Lipopeptide Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Negative Regulation Of Toll Signaling Pathway Regulation Of Signal Transduction Response To Stress Positive Regulation Of Immune Response Eosinophil Homeostasis Positive Regulation Of Type III Hypersensitivity Regulation Of Multicellular Organismal Process Positive Regulation Of Signal Transduction Regulation Of Type I Interferon Production Phospholipase C Activator Activity Regulation Of JNK Cascade Cellular Response To Triacyl Bacterial Lipopeptide Antigen Receptor-mediated Signaling Pathway Regulation Of Interleukin-6 Production Positive Regulation Of Synoviocyte Proliferation Pattern Recognition Receptor Signaling Pathway Perinuclear Region Of Cytoplasm Cellular Response To Molecule Of Fungal Origin Toll-like Receptor 2 Binding Detection Of Bacterial Lipoprotein Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Tumor Necrosis Factor Production Innate Immune Response-activating Signaling Pathway Defense Response To Other Organism Regulation Of Cell Communication
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