TLL1 and CHRD

Number of citations of the paper that reports this interaction (PMID 10479448)
49

Data Source:
HPRD (in vitro)

		TLL1	CHRD
Gene Name		tolloid-like 1	chordin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region	Extracellular Space
	Molecular Function	Metalloendopeptidase Activity Calcium Ion Binding Collagen Binding Zinc Ion Binding	Protein Binding Heparin Binding Cytokine Binding Syndecan Binding
	Biological Process	Skeletal System Development Proteolysis Extracellular Matrix Disassembly Cell Differentiation Extracellular Matrix Organization	Skeletal System Development Osteoblast Differentiation Gastrulation With Mouth Forming Second Mesoderm Formation Positive Regulation Of Mesenchymal Cell Proliferation BMP Signaling Pathway Involved In Spinal Cord Dorsal/ventral Patterning Negative Regulation Of Cell Migration Negative Regulation Of BMP Signaling Pathway Forebrain Development Floor Plate Development Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Adhesion
Pathways		Collagen formation Crosslinking of collagen fibrils Anchoring fibril formation Collagen biosynthesis and modifying enzymes Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs
Diseases
GWAS		Multiple sclerosis ( 23412934) Obesity-related traits ( 23251661) Post-traumatic stress disorder ( 23726511) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)	Platelet counts ( 20139978)
Protein-Protein Interactions		2 interactors: APP CHRD	26 interactors: ATN1 BMP1 BMP2 CATSPER1 CD36 F2R HOXA1 HRG KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 KRTAP9-2 MEOX2 NOTCH2NL NR0B2 OTX1 PLSCR1 SMAD3 SPRY2 TLL1 TWSG1
Entrez ID		7092	8646
HPRD ID		07074	04592
Ensembl ID		ENSG00000038295	ENSG00000090539
Uniprot IDs		B7ZLW3 E9PD25 O43897	E7ESX1 Q9H2X0
PDB IDs		3EDI
Enriched GO Terms of Interacting Partners?		BMP Signaling Pathway Involved In Spinal Cord Dorsal/ventral Patterning Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Forebrain Development Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Axon Choice Point Recognition Floor Plate Development Neuron Remodeling Negative Regulation Of Cell Differentiation Brain Development Head Development Cellular Copper Ion Homeostasis Central Nervous System Development Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Spinal Cord Dorsal/ventral Patterning Negative Regulation Of Smoothened Signaling Pathway Spinal Cord Patterning Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis RNA Polyadenylation Neuron Recognition Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of BMP Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Osteoblast Differentiation Regulation Of Mesenchymal Cell Proliferation Axon Cargo Transport Mating Neuromuscular Junction Development Regulation Of Cell Differentiation Positive Regulation Of Mitotic Cell Cycle Phase Transition Gastrulation With Mouth Forming Second Neuron Apoptotic Process Positive Regulation Of Cell Cycle Phase Transition Regulation Of Protein Tyrosine Kinase Activity Visual Learning Glutamate Receptor Signaling Pathway Visual Behavior Neuron Death	Developmental Process Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Anatomical Structure Development Positive Regulation Of Gene Expression Anterior/posterior Pattern Specification Positive Regulation Of Blood Coagulation Regulation Of Wound Healing Anatomical Structure Morphogenesis Positive Regulation Of Coagulation Positive Regulation Of Cartilage Development Sensory Organ Development Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Wound Healing Organ Morphogenesis System Development Regulation Of Transcription, DNA-templated Positive Regulation Of Cell-matrix Adhesion Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Inner Ear Development Embryo Development Platelet Activation Pattern Specification Process Embryonic Organ Development Ear Development Positive Regulation Of Transcription, DNA-templated Response To Organic Substance Regulation Of Cartilage Development Positive Regulation Of Cellular Metabolic Process Skeletal System Development Regulation Of Blood Coagulation Ossification Positive Regulation Of Metabolic Process Inner Ear Morphogenesis Wound Healing Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cell Motility Embryonic Organ Morphogenesis Regulation Of Cell-matrix Adhesion Embryonic Morphogenesis Regulation Of Protein Phosphorylation Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Cellular Biosynthetic Process Regulation Of Osteoblast Proliferation Negative Regulation Of Cell Proliferation
Tagcloud ?		abcc8 acacb cacna1a camk2d cdkal1 chi csmd1 disequilibrium exome glud1 gnas hnf1a hyperinsulinism kcnh6 kcnj10 kcnj11 nos2 notch2 pde4c pik3r3 probands ryr3 scn8a slc24a6 slc37a3 sulf1 tdt trpc5 trpv3	affymetrix axin2 bglap2 bmp bridge chrdl2 cooperatively cpz csnk2a1 deformities fgfr1 fibrogenic fzd1 fzd2 groupings hgn id1 lef1 microdissection mmp9 osteogenic plate remodelling repaired sfrp1 sfrp4 spp1 tcf7 wisp1
Tagcloud (Difference) ?		abcc8 acacb cacna1a camk2d cdkal1 chi csmd1 disequilibrium exome glud1 gnas hnf1a hyperinsulinism kcnh6 kcnj10 kcnj11 nos2 notch2 pde4c pik3r3 probands ryr3 scn8a slc24a6 slc37a3 sulf1 tdt trpc5 trpv3	affymetrix axin2 bglap2 bmp bridge chrdl2 cooperatively cpz csnk2a1 deformities fgfr1 fibrogenic fzd1 fzd2 groupings hgn id1 lef1 microdissection mmp9 osteogenic plate remodelling repaired sfrp1 sfrp4 spp1 tcf7 wisp1
Tagcloud (Intersection) ?