TLL1

Gene Name		tolloid-like 1
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Gene Ontology Annotations	Cellular Component	Extracellular Region
	Molecular Function	Metalloendopeptidase Activity Calcium Ion Binding Collagen Binding Zinc Ion Binding
	Biological Process	Skeletal System Development Proteolysis Extracellular Matrix Disassembly Cell Differentiation Extracellular Matrix Organization
Pathways		Collagen formation Crosslinking of collagen fibrils Anchoring fibril formation Collagen biosynthesis and modifying enzymes Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs
Diseases
GWAS		Multiple sclerosis ( 23412934) Obesity-related traits ( 23251661) Post-traumatic stress disorder ( 23726511) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)
Protein-protein Interactions		2 interactors: APP CHRD
Entrez ID		7092
HPRD ID		07074
Ensembl ID		ENSG00000038295
Uniprot IDs		B7ZLW3 E9PD25 O43897
PDB IDs		3EDI
Enriched GO Terms of Interacting Partners?		BMP Signaling Pathway Involved In Spinal Cord Dorsal/ventral Patterning Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Forebrain Development Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Axon Choice Point Recognition Floor Plate Development Neuron Remodeling Negative Regulation Of Cell Differentiation Brain Development Head Development Cellular Copper Ion Homeostasis Central Nervous System Development Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Spinal Cord Dorsal/ventral Patterning Negative Regulation Of Smoothened Signaling Pathway Spinal Cord Patterning Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis RNA Polyadenylation Neuron Recognition Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of BMP Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Osteoblast Differentiation Regulation Of Mesenchymal Cell Proliferation Axon Cargo Transport Mating Neuromuscular Junction Development Regulation Of Cell Differentiation Positive Regulation Of Mitotic Cell Cycle Phase Transition Gastrulation With Mouth Forming Second Neuron Apoptotic Process Positive Regulation Of Cell Cycle Phase Transition Regulation Of Protein Tyrosine Kinase Activity Visual Learning Glutamate Receptor Signaling Pathway Visual Behavior Neuron Death See more
Tagcloud ?		abcc8 acacb cacna1a camk2d cdkal1 chi csmd1 disequilibrium exome glud1 gnas hnf1a hyperinsulinism kcnh6 kcnj10 kcnj11 nos2 notch2 pde4c pik3r3 probands ryr3 scn8a slc24a6 slc37a3 sulf1 tdt trpc5 trpv3