ATP1A2

Name	ATPase Na+/K+ transporting subunit alpha 2
Structure	No pdb structure
Interactors	2 interactors: TIAM1 TPT1
GO Annotations	Cellular Component	Cytoplasm Endosome Endoplasmic Reticulum Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Cell Surface Intercalated Disc Membrane T-tubule Organelle Membrane Protein-containing Complex Sarcolemma Cell Projection Neuronal Cell Body Dendritic Spine Extracellular Vesicle
	Molecular Function	Nucleotide Binding P-type Sodium:potassium-exchanging Transporter Activity Steroid Binding Protein Binding ATP Binding P-type Potassium Transmembrane Transporter Activity Phosphatase Activity ATP Hydrolysis Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Potassium Ion Binding Sodium Ion Binding Metal Ion Binding Protein Heterodimerization Activity Protein-folding Chaperone Binding Steroid Hormone Binding
	Biological Process	Neurotransmitter Uptake Behavioral Fear Response Regulation Of The Force Of Heart Contraction Regulation Of Respiratory Gaseous Exchange By Nervous System Process Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Regulation Of Muscle Contraction Regulation Of Smooth Muscle Contraction Regulation Of Striated Muscle Contraction Cell Communication Blood Circulation Regulation Of Heart Contraction Regulation Of Blood Pressure Adult Locomotory Behavior Visual Learning Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Response To Auditory Stimulus Neuronal Action Potential Propagation Regulation Of Vasoconstriction L-ascorbic Acid Metabolic Process Amygdala Development Olfactory Cortex Development Intracellular Monoatomic Cation Homeostasis Intracellular Potassium Ion Homeostasis Response To Nicotine Locomotory Exploration Behavior Sodium Ion Transmembrane Transport Response To Potassium Ion Sodium Ion Export Across Plasma Membrane Locomotion Fear Response Negative Regulation Of Heart Contraction Positive Regulation Of Heart Contraction Negative Regulation Of Striated Muscle Contraction ATP Metabolic Process Negative Regulation Of Cytosolic Calcium Ion Concentration Membrane Depolarization Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Regulation Of Synaptic Transmission, Glutamatergic Relaxation Of Cardiac Muscle Cardiac Muscle Contraction Cellular Response To Mechanical Stimulus Cellular Response To Steroid Hormone Stimulus Potassium Ion Transmembrane Transport Regulation Of Cardiac Muscle Cell Contraction Membrane Repolarization Membrane Depolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Monoatomic Cation Transmembrane Transport Transport Across Blood-brain Barrier Proton Transmembrane Transport Negative Regulation Of Calcium Ion Transmembrane Transport Response To Glycoside Potassium Ion Import Across Plasma Membrane
Pathways	Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs	Ouabain Bisacodyl Tegoprazan
Diseases	Familial or sporadic hemiplegic migraine Alternating hemiplegia of childhood
GWAS	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Response to antipsychotic treatment ( 23241943 )
Entrez ID	477
HPRD ID	01665
Ensembl ID	ENSG00000018625
Uniprot IDs	A0A0S2Z3W6 B4DIQ8 P50993
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Negative Regulation Of Ectoderm Development