SLC6A3 and TGFB1I1

Number of citations of the paper that reports this interaction (PubMedID 12177201)
46

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		SLC6A3	TGFB1I1
Description		solute carrier family 6 member 3	transforming growth factor beta 1 induced transcript 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Surface Membrane Flotillin Complex Axon Presynaptic Membrane Cell Projection Neuron Projection Neuronal Cell Body Axon Terminus Membrane Raft Postsynaptic Membrane Dopaminergic Synapse	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Nuclear Matrix Extracellular Matrix Anchoring Junction
	Molecular Function	Protease Binding Signaling Receptor Binding Neurotransmitter Transmembrane Transporter Activity Dopamine:sodium Symporter Activity Norepinephrine:sodium Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Symporter Activity Transmembrane Transporter Activity Dopamine Binding Amine Binding Protein-containing Complex Binding Metal Ion Binding Protein Phosphatase 2A Binding Heterocyclic Compound Binding	Transcription Coactivator Activity Protein Binding Metal Ion Binding Roundabout Binding Nuclear Androgen Receptor Binding I-SMAD Binding
	Biological Process	Neurotransmitter Uptake Neurotransmitter Transport Amino Acid Transport Lactation Sensory Perception Of Smell Locomotory Behavior Response To Xenobiotic Stimulus Response To Iron Ion Monoamine Transport Dopamine Transport Adenohypophysis Development Response To Nicotine Sodium Ion Transmembrane Transport Positive Regulation Of Multicellular Organism Growth Regulation Of Dopamine Metabolic Process Response To Cocaine Dopamine Biosynthetic Process Dopamine Catabolic Process Response To Ethanol Cognition Dopamine Uptake Involved In Synaptic Transmission Response To CAMP Norepinephrine Uptake Prepulse Inhibition Dopamine Uptake Hyaloid Vascular Plexus Regression	Cell Adhesion Negative Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Wnt Signaling Pathway Morphogenesis Of Embryonic Epithelium Cell Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Epithelial Cell Differentiation Cell Fate Commitment Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Dopamine clearance from the synaptic cleft SLC-mediated transport of neurotransmitters Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)
Drugs		Amphetamine Phentermine Benzatropine Venlafaxine Loxapine Methylphenidate Meperidine Imipramine Duloxetine Amoxapine Mazindol Procaine Trimipramine Modafinil Phenmetrazine Pseudoephedrine Benzphetamine Cocaine Diethylpropion Dopamine Sertraline Sibutramine Chlorpheniramine Diphenylpyraline Nefazodone Bupropion Chloroprocaine Escitalopram Aripiprazole Ephedra sinica root MMDA Midomafetamine Fencamfamin 4-Methoxyamphetamine Dextroamphetamine Metamfetamine Vanoxerine Nomifensine Altropane Mianserin Tesofensine Trodusquemine Armodafinil Desvenlafaxine Dexmethylphenidate Dasotraline Solriamfetol Serdexmethylphenidate
Diseases
GWAS		Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Pancreatic cancer ( 25086665)	Metabolite levels ( 23823483)
Interacting Genes		9 interacting genes: DRD2 MTNR1A NEDD4 PICK1 RACK1 SNCA SNTA1 STX1A TGFB1I1	33 interacting genes: AR CBLB CBLC CDKN2B CRKL CSK EP300 FKBP1A GIT1 GIT2 GP1BB HIPK3 HOXA1 HSPB1 ITCH ITGA4 MAPK15 NEDD4 NEDD4L NR3C1 PLA2G3 PTK2 PTK2B PTPN12 SDC4 SLC6A3 SMAD7 SVIL TGFBR2 TRAF4 UBQLN4 VCL YAP1
Entrez ID		6531	7041
HPRD ID		00543	03831
Ensembl ID		ENSG00000142319	ENSG00000140682
Uniprot IDs		Q01959	O43294
PDB IDs		8VBY 8Y2C 8Y2D 8Y2E 8Y2F 8Y2G 9EO4
Enriched GO Terms of Interacting Partners?		Regulation Of Membrane Potential Monoamine Transport Regulation Of Catecholamine Secretion Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Transport Regulation Of Sodium Ion Transport Receptor Internalization Regulation Of Vesicle-mediated Transport Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Transport Regulation Of Amine Transport Catecholamine Uptake Dopamine Uptake SNARE Complex Assembly Neurotransmitter Transport Regulation Of Endocytosis Synaptic Transmission, Dopaminergic Behavioral Response To Cocaine Regulation Of Metal Ion Transport Presynaptic Membrane Dopamine Transport Neurotransmitter Reuptake Synaptic Vesicle Membrane Regulation Of Neurotransmitter Uptake Positive Regulation Of Neurotransmitter Secretion Synaptic Vesicle Transmembrane Transporter Binding Positive Regulation Of Synaptic Transmission Regulation Of Dopamine Secretion Regulation Of Monoatomic Ion Transport Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Transport Regulation Of Protein Transport Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Endocytosis Endocytosis Regulation Of Insulin Secretion Regulation Of Protein Localization Positive Regulation Of Receptor Internalization Neurotransmitter Uptake Receptor-mediated Endocytosis Dopamine Metabolic Process Ionotropic Glutamate Receptor Binding Response To Iron Ion Modulation Of Chemical Synaptic Transmission Synaptic Vesicle Exocytosis Ribosome Regulation Of Peptide Hormone Secretion Regulation Of Synaptic Plasticity Regulation Of Establishment Of Protein Localization	Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway Developmental Process Focal Adhesion Regulation Of Signal Transduction Regulation Of Cell Adhesion Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Anchoring Junction Regulation Of Multicellular Organismal Process Response To Growth Factor Negative Regulation Of Signal Transduction Cell Activation Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell-cell Adhesion Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of T Cell Tolerance Induction Type I Transforming Growth Factor Beta Receptor Binding Cellular Response To Growth Factor Stimulus Leukocyte Activation Positive Regulation Of Tolerance Induction Regulation Of Cell Population Proliferation Signal Transduction Positive Regulation Of Multicellular Organismal Process Regulation Of T Cell Tolerance Induction Anatomical Structure Morphogenesis Transferase Activity Costamere Negative Regulation Of Cell-cell Adhesion Regulation Of Protein Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Regulation Of Alpha-beta T Cell Activation Positive Regulation Of Cell Adhesion Plasma Membrane Proline-rich Region Binding Cytosol Regulation Of Immune System Process Regulation Of Tolerance Induction Negative Regulation Of T Cell Activation Developmental Growth Protein Modification Process Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Regulation Of T Cell Activation Positive Regulation Of Catabolic Process Regulation Of Apoptotic Process Tissue Morphogenesis
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