SLC6A3

Description		solute carrier family 6 member 3
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Surface Membrane Flotillin Complex Axon Presynaptic Membrane Cell Projection Neuron Projection Neuronal Cell Body Axon Terminus Membrane Raft Postsynaptic Membrane Dopaminergic Synapse
	Molecular Function	Protease Binding Signaling Receptor Binding Neurotransmitter Transmembrane Transporter Activity Dopamine:sodium Symporter Activity Norepinephrine:sodium Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Symporter Activity Transmembrane Transporter Activity Dopamine Binding Amine Binding Protein-containing Complex Binding Metal Ion Binding Protein Phosphatase 2A Binding Heterocyclic Compound Binding
	Biological Process	Neurotransmitter Uptake Neurotransmitter Transport Amino Acid Transport Lactation Sensory Perception Of Smell Locomotory Behavior Response To Xenobiotic Stimulus Response To Iron Ion Monoamine Transport Dopamine Transport Adenohypophysis Development Response To Nicotine Sodium Ion Transmembrane Transport Positive Regulation Of Multicellular Organism Growth Regulation Of Dopamine Metabolic Process Response To Cocaine Dopamine Biosynthetic Process Dopamine Catabolic Process Response To Ethanol Cognition Dopamine Uptake Involved In Synaptic Transmission Response To CAMP Norepinephrine Uptake Prepulse Inhibition Dopamine Uptake Hyaloid Vascular Plexus Regression
Pathways		Dopamine clearance from the synaptic cleft SLC-mediated transport of neurotransmitters Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)
Drugs		Amphetamine Phentermine Benzatropine Venlafaxine Loxapine Methylphenidate Meperidine Imipramine Duloxetine Amoxapine Mazindol Procaine Trimipramine Modafinil Phenmetrazine Pseudoephedrine Benzphetamine Cocaine Diethylpropion Dopamine Sertraline Sibutramine Chlorpheniramine Diphenylpyraline Nefazodone Bupropion Chloroprocaine Escitalopram Aripiprazole Ephedra sinica root MMDA Midomafetamine Fencamfamin 4-Methoxyamphetamine Dextroamphetamine Metamfetamine Vanoxerine Nomifensine Altropane Mianserin Tesofensine Trodusquemine Armodafinil Desvenlafaxine Dexmethylphenidate Dasotraline Solriamfetol Serdexmethylphenidate
Diseases
GWAS		Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Pancreatic cancer ( 25086665)
Novel Interacting Genes		2 novel interacting genes: AHRR MRPL36
Interacting Genes		9 interacting genes: DRD2 MTNR1A NEDD4 PICK1 RACK1 SNCA SNTA1 STX1A TGFB1I1
Entrez ID		6531
HPRD ID		00543
Ensembl ID		ENSG00000142319
Uniprot IDs		Q01959
PDB IDs		8VBY 8Y2C 8Y2D 8Y2E 8Y2F 8Y2G 9EO4
Enriched GO Terms of Interacting Partners?		Regulation Of Membrane Potential Monoamine Transport Regulation Of Catecholamine Secretion Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Transport Regulation Of Sodium Ion Transport Receptor Internalization Regulation Of Vesicle-mediated Transport Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Transport Regulation Of Amine Transport Catecholamine Uptake Dopamine Uptake SNARE Complex Assembly Neurotransmitter Transport Regulation Of Endocytosis Synaptic Transmission, Dopaminergic Behavioral Response To Cocaine Regulation Of Metal Ion Transport Presynaptic Membrane Dopamine Transport Neurotransmitter Reuptake Synaptic Vesicle Membrane Regulation Of Neurotransmitter Uptake Positive Regulation Of Neurotransmitter Secretion Synaptic Vesicle Transmembrane Transporter Binding Positive Regulation Of Synaptic Transmission Regulation Of Dopamine Secretion Regulation Of Monoatomic Ion Transport Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Transport Regulation Of Protein Transport Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Endocytosis Endocytosis Regulation Of Insulin Secretion Regulation Of Protein Localization Positive Regulation Of Receptor Internalization Neurotransmitter Uptake Receptor-mediated Endocytosis Dopamine Metabolic Process Ionotropic Glutamate Receptor Binding Response To Iron Ion Modulation Of Chemical Synaptic Transmission Synaptic Vesicle Exocytosis Ribosome Regulation Of Peptide Hormone Secretion Regulation Of Synaptic Plasticity Regulation Of Establishment Of Protein Localization
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