DCLRE1B and SPAG5

Number of citations of the paper that reports this interaction (PubMedID 19197158)
0

Data Source:
BioGRID (pull down)

		DCLRE1B	SPAG5
Description		DNA cross-link repair 1B	sperm associated antigen 5
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytoskeleton Nuclear Body	Chromosome, Centromeric Region Kinetochore Spindle Pole Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Microtubule Nuclear Body Midbody Centriolar Satellite Ciliary Rootlet Microtubule Plus-end Ciliary Basal Body Mitotic Spindle Mitotic Spindle Pole
	Molecular Function	Damaged DNA Binding Nuclease Activity Exonuclease Activity Protein Binding 5'-3' Exonuclease Activity Beta-lactamase Activity Hydrolase Activity 5'-3' DNA Exonuclease Activity Protein Homodimerization Activity Protein-containing Complex Binding	Protein Binding Microtubule Binding
	Biological Process	Telomere Maintenance DNA Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response Telomere Maintenance Via Telomere Lengthening Telomere Capping Telomeric Loop Formation Protection From Non-homologous End Joining At Telomere Telomeric 3' Overhang Formation Interstrand Cross-link Repair	Mitotic Sister Chromatid Segregation Spindle Organization Chromosome Segregation Positive Regulation Of Intracellular Transport Establishment Of Spindle Orientation Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Protein Localization To Centrosome Regulation Of Metaphase Plate Congression Positive Regulation Of Spindle Assembly
Pathways		Fanconi Anemia Pathway
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Breast cancer ( 23535729 29059683) Coronary artery disease ( 33020668) Crohn's disease ( 23128233 28067908) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965)
Interacting Genes		4 interacting genes: NOXA1 SPAG5 TFR2 TRIM54	59 interacting genes: AIRIM AMOTL2 ARNT2 ATN1 BARD1 CCDC33 CCHCR1 CDC20B CDK1 CENPH CHCHD3 DCLRE1B DCX EIF4E2 EIF4ENIF1 ENKD1 FBXO28 FMR1 GEM GOLGA8EP GOLGA8F HAUS1 IGFN1 IQCE KANSL1 KRT3 KRT75 LGALS14 LINGO1 MID1 MID2 NEBL NLGN3 ODF1 ORC6 PIMREG PKN1 PLK4 POLR2L POM121 RBM41 SH2D4A SHANK3 SMARCA2 SMARCE1 SNAP47 SNAPIN SPAG5-AS1 TSC1 TSHZ3 TTC23 ZC2HC1C ZFC3H1 ZFYVE26 ZGPAT ZMAT2 ZNF385C ZNF572 ZNF688
Entrez ID		64858	10615
HPRD ID		16785	10246
Ensembl ID		ENSG00000118655	ENSG00000076382
Uniprot IDs		Q9H816	Q96R06
PDB IDs		3BUA 5AHO 7A1F 7B2X 7B9B
Enriched GO Terms of Interacting Partners?		Transferrin Receptor Activity Endocytic Iron Import Into Cell Regulation Of Microtubule Cytoskeleton Organization HFE-transferrin Receptor Complex Cellular Response To Iron Ion Iron Import Into Cell Regulation Of Microtubule-based Process Positive Regulation Of Spindle Assembly Ciliary Rootlet Microtubule Binding Superoxide-generating NADPH Oxidase Activator Activity Microtubule Transferrin Transport Co-receptor Binding Regulation Of Metaphase Plate Congression
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