DCLRE1B

Description		DNA cross-link repair 1B
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytoskeleton Nuclear Body
	Molecular Function	Damaged DNA Binding Nuclease Activity Exonuclease Activity Protein Binding 5'-3' Exonuclease Activity Beta-lactamase Activity Hydrolase Activity 5'-3' DNA Exonuclease Activity Protein Homodimerization Activity Protein-containing Complex Binding
	Biological Process	Telomere Maintenance DNA Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response Telomere Maintenance Via Telomere Lengthening Telomere Capping Telomeric Loop Formation Protection From Non-homologous End Joining At Telomere Telomeric 3' Overhang Formation Interstrand Cross-link Repair
Pathways		Fanconi Anemia Pathway
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Breast cancer ( 23535729 29059683) Coronary artery disease ( 33020668) Crohn's disease ( 23128233 28067908) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965)
Interacting Genes		4 interacting genes: NOXA1 SPAG5 TFR2 TRIM54
Entrez ID		64858
HPRD ID		16785
Ensembl ID		ENSG00000118655
Uniprot IDs		Q9H816
PDB IDs		3BUA 5AHO 7A1F 7B2X 7B9B
Enriched GO Terms of Interacting Partners?		Transferrin Receptor Activity Endocytic Iron Import Into Cell Regulation Of Microtubule Cytoskeleton Organization HFE-transferrin Receptor Complex Cellular Response To Iron Ion Iron Import Into Cell Regulation Of Microtubule-based Process Positive Regulation Of Spindle Assembly Ciliary Rootlet Microtubule Binding Superoxide-generating NADPH Oxidase Activator Activity Microtubule Transferrin Transport Co-receptor Binding Regulation Of Metaphase Plate Congression
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