ASMTL and HLA-DRB4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ASMTL	HLA-DRB4
Description		acetylserotonin O-methyltransferase like	major histocompatibility complex, class II, DR beta 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Golgi Membrane Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding Methyltransferase Activity O-methyltransferase Activity Transferase Activity Hydrolase Activity DTTP Diphosphatase Activity UTP Diphosphatase Activity Protein Dimerization Activity Nucleoside Triphosphate Diphosphatase Activity	MHC Class II Protein Complex Binding Peptide Antigen Binding
	Biological Process	Nucleotide Metabolic Process Methylation	Adaptive Immune Response Immune System Process Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Immune Response Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation
Pathways			Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation Co-inhibition by PD-1 Interferon gamma signaling
Drugs			1D09C3 Coccidioides immitis spherule
Diseases
GWAS
Interacting Genes		10 interacting genes: APP GORASP2 HLA-DRB4 KRT31 KRT34 KRT40 PNMA1 REL TDO2 ZNF655	3 interacting genes: ASMTL CTAG1B MAGEA6
Entrez ID		8623	3126
HPRD ID		02156	09986
Ensembl ID		ENSG00000169093
Uniprot IDs		B3KM43 O95671	P13762 X5D2U9
PDB IDs		2P5X 6XI4 6XI5
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Intermediate Filament Supramolecular Fiber Organization Structural Molecule Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway L-tryptophan Catabolic Process To Acetyl-CoA Morphogenesis Of An Epithelium Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Protein Tetramerization Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Epithelial Cell Differentiation Tissue Morphogenesis Tryptophan 2,3-dioxygenase Activity Response To Nitroglycerin Trans-Golgi Network Membrane Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling NF-kappaB Complex Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon L-tryptophan Catabolic Process To Kynurenine Epidermis Development Immune Response Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity	DTTP Diphosphatase Activity UTP Diphosphatase Activity O-methyltransferase Activity Nucleoside Triphosphate Diphosphatase Activity TRNA Threonylcarbamoyladenosine Metabolic Process
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