ASMTL and HLA-DRB4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ASMTL	HLA-DRB4
Gene Name		acetylserotonin O-methyltransferase-like	major histocompatibility complex, class II, DR beta 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Golgi Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane ER To Golgi Transport Vesicle Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Molecular_function O-methyltransferase Activity	Protein Binding MHC Class II Receptor Activity Peptide Antigen Binding
	Biological Process	Biological_process Methylation	Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Inflammatory Response To Antigenic Stimulus Humoral Immune Response Mediated By Circulating Immunoglobulin Peptide Antigen Assembly With MHC Class II Protein Complex Negative Regulation Of Inflammatory Response To Antigenic Stimulus Immune Response Signal Transduction Detection Of Bacterium Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Costimulation Regulation Of Interleukin-4 Production Negative Regulation Of Interferon-gamma Production Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus T-helper 1 Type Immune Response Negative Regulation Of T Cell Proliferation T Cell Receptor Signaling Pathway Protein Tetramerization Interferon-gamma-mediated Signaling Pathway Regulation Of Interleukin-10 Secretion
Pathways			Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: APP HLA-DRB4 KRT31 KRT40 PNMA1 TDO2 UBC	3 interactors: ASMTL CTAG1B MAGEA6
Entrez ID		8623	3126
HPRD ID		02156	09986
Ensembl ID		ENSG00000169093
Uniprot IDs		B3KM43 E7ER97 O95671	P13762
PDB IDs		2P5X
Enriched GO Terms of Interacting Partners?		Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Immune Response Defense Response Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway T Cell Receptor Signaling Pathway Synaptic Growth At Neuromuscular Junction Tryptophan Catabolic Process To Acetyl-CoA Antigen Receptor-mediated Signaling Pathway Notch Signaling Pathway Innate Immune Response Collateral Sprouting In Absence Of Injury Immune System Process Intracellular Receptor Signaling Pathway Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Antigen Processing And Presentation Of Peptide Antigen Regulation Of Cell Cycle Phase Transition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Cycle Antigen Processing And Presentation Positive Regulation Of Proteolysis Neuron Remodeling Tryptophan Catabolic Process To Kynurenine Viral Protein Processing Kynurenine Metabolic Process
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