TCOF1 and UBTF

Number of citations: 61 (PubMedID 15249688)
Data Source: HPRD (in vivo, two hybrid)

		TCOF1	UBTF
Name		treacle ribosome biogenesis factor 1	upstream binding transcription factor
Structure		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytosol	Fibrillar Center Nucleus Nucleoplasm Nucleolus
	Molecular Function	RNA Binding Protein Binding Protein-macromolecule Adaptor Activity Protein Heterodimerization Activity Scaffold Protein Binding	RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase I General Transcription Initiation Factor Activity DNA Binding Chromatin Binding RNA Binding Protein Binding Scaffold Protein Binding
	Biological Process	Skeletal System Development Regulation Of Translation Neural Crest Formation Neural Crest Cell Development Nucleolar Large RRNA Transcription By RNA Polymerase I	RNA Polymerase I Preinitiation Complex Assembly Transcription By RNA Polymerase I Transcription Initiation At RNA Polymerase I Promoter Positive Regulation Of Transcription By RNA Polymerase I Regulation Of Glucose Mediated Signaling Pathway
Pathways		None	NoRC negatively regulates rRNA expression RNA Polymerase I Promoter Opening RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Diseases		Treacher Collins syndrome	None
GWAS		Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 28067908 )	Bipolar disorder ( 31043756 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Diverticular disease ( 30177863 ) hemolysis of donated blood (osmotic) ( 34014839 ) Mean corpuscular hemoglobin concentration ( 29403010 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 )
Interacting Genes		11 interacting genes: CRK CSNK2A1 CSNK2A2 NOP56 PCNA PKNOX1 SPOP SRPK2 TM9SF1 UBC UBTF	37 interacting genes: AURKA CCNA2 CCND1 CCNE1 CDK2 CDK4 CEBPA CENPC CHGB CREBBP CSNK2A1 EP300 GSK3A IRS1 IRS2 LEF1 MAD1L1 MAPK1 MAPK3 MDM2 POLR1E POLR1G RB1 RBL2 RNF10 RUNX2 SERPINH1 SMURF1 TAF1 TAF1A TAF1B TAF1C TAF1D TBP TCOF1 USP7 ZMYM2
Entrez ID		6949	7343
HPRD ID		06026	02814
Ensembl ID		ENSG00000070814	ENSG00000108312
Uniprot IDs		B4DRA2 E7ETY2 Q13428	P17480
PDB IDs		Not available	1K99 1L8Y 1L8Z 2HDZ
GO Terms Enriched among Interactors		Protein Kinase CK2 Complex Nucleic Acid Metabolic Process PcG Protein Complex Liver Regeneration Nucleus Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Helper T Cell Diapedesis Cerebral Cortex Development Protein Phosphorylated Amino Acid Binding Ubiquitin Protein Ligase Binding Receptor Tyrosine Kinase Binding Scaffold Protein Binding Response To Cholecystokinin Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Serine Kinase Activity Nucleoplasm Negative Regulation Of Proteasomal Protein Catabolic Process RNA Metabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Chromosome Separation Animal Organ Regeneration PCNA Complex PCNA-p21 Complex Replisome DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Proteolysis Cerebellar Neuron Development Response To Hydrogen Peroxide Protein Serine/threonine Kinase Activity Symbiont-mediated Disruption Of Host Cell PML Body Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Liver Development Positive Regulation Of Deoxyribonuclease Activity Leading Strand Elongation Nuclear Speck Organization Regulation Of Glucose Mediated Signaling Pathway Negative Regulation Of Protein Catabolic Process Regulation Of Primary Metabolic Process Regulation Of Chromosome Segregation Positive Regulation Of Aggrephagy Regeneration Chromatin Binding RNA Polymerase I General Transcription Initiation Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Kinase Activity	Transcription By RNA Polymerase I DNA-templated Transcription RNA Polymerase Transcription Factor SL1 Complex Nucleoplasm Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleus Transcription Regulator Complex Nucleobase-containing Compound Biosynthetic Process Regulation Of Proteasomal Protein Catabolic Process Transcription Initiation At RNA Polymerase I Promoter Regulation Of Cell Cycle Phase Transition Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Nucleic Acid Metabolic Process RNA Polymerase I Preinitiation Complex Assembly Regulation Of Proteolysis RNA Metabolic Process RNA Polymerase I Transcription Regulator Complex Positive Regulation Of Mitotic Cell Cycle Regulation Of Cell Population Proliferation Macromolecule Biosynthetic Process Positive Regulation Of Catabolic Process Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Process Regulation Of RNA Metabolic Process Positive Regulation Of Cell Population Proliferation Cell Division Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleolar Large RRNA Transcription By RNA Polymerase I Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Protein Catabolic Process Regulation Of Protein Stability Gland Development DNA-binding Transcription Factor Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle