TCOF1

Name	treacle ribosome biogenesis factor 1
Structure	No pdb structure
Interactors	11 interactors: CRK CSNK2A1 CSNK2A2 NOP56 PCNA PKNOX1 SPOP SRPK2 TM9SF1 UBC UBTF
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytosol
	Molecular Function	RNA Binding Protein Binding Protein-macromolecule Adaptor Activity Protein Heterodimerization Activity Scaffold Protein Binding
	Biological Process	Skeletal System Development Regulation Of Translation Neural Crest Formation Neural Crest Cell Development Nucleolar Large RRNA Transcription By RNA Polymerase I
Diseases	Treacher Collins syndrome
GWAS	Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 28067908 )
Entrez ID	6949
HPRD ID	06026
Ensembl ID	ENSG00000070814
Uniprot IDs	B4DRA2 E7ETY2 Q13428
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Protein Kinase CK2 Complex Nucleic Acid Metabolic Process PcG Protein Complex Liver Regeneration Nucleus Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Helper T Cell Diapedesis Cerebral Cortex Development Protein Phosphorylated Amino Acid Binding Ubiquitin Protein Ligase Binding Receptor Tyrosine Kinase Binding Scaffold Protein Binding Response To Cholecystokinin Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Serine Kinase Activity Nucleoplasm Negative Regulation Of Proteasomal Protein Catabolic Process RNA Metabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Chromosome Separation Animal Organ Regeneration PCNA Complex PCNA-p21 Complex Replisome DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Proteolysis Cerebellar Neuron Development Response To Hydrogen Peroxide Protein Serine/threonine Kinase Activity Symbiont-mediated Disruption Of Host Cell PML Body Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Liver Development Positive Regulation Of Deoxyribonuclease Activity Leading Strand Elongation Nuclear Speck Organization Regulation Of Glucose Mediated Signaling Pathway Negative Regulation Of Protein Catabolic Process Regulation Of Primary Metabolic Process Regulation Of Chromosome Segregation Positive Regulation Of Aggrephagy Regeneration Chromatin Binding RNA Polymerase I General Transcription Initiation Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Kinase Activity