RNASEL and ABCE1

Number of citations of the paper that reports this interaction (PubMedID 7539425)
0

Data Source:
HPRD (in vitro)

		RNASEL	ABCE1
Description		ribonuclease L	ATP binding cassette subfamily E member 1
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Nuclear Matrix	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Membrane Cytosolic Ribosome
	Molecular Function	Nucleotide Binding RNA Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity RNA Nuclease Activity Protein Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity RRNA Binding Identical Protein Binding Ribonucleoprotein Complex Binding Metal Ion Binding	Nucleotide Binding GTPase Activity Iron Ion Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Ribonucleoside Triphosphate Phosphatase Activity Ribosomal Small Subunit Binding CTPase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding Endoribonuclease Inhibitor Activity
	Biological Process	RRNA Processing RNA Processing MRNA Processing Protein Phosphorylation Regulation Of Gene Expression Regulation Of MRNA Stability Negative Regulation Of Viral Genome Replication Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of D-glucose Import Regulation Of RNA Metabolic Process Defense Response To Virus	Translation Translational Initiation Translational Termination Regulation Of Translation Ribosome Disassembly Regulation Of Macromolecule Metabolic Process Negative Regulation Of Endoribonuclease Activity Protein Ufmylation Rescue Of Stalled Ribosome CAT Tailing Ribosome-associated Ubiquitin-dependent Protein Catabolic Process
Pathways		OAS antiviral response Interferon alpha/beta signaling	OAS antiviral response Interferon alpha/beta signaling PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA
Drugs
Diseases
GWAS		Morning vs. evening chronotype ( 26835600) Multiple sclerosis ( 23412934)	Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Hip circumference adjusted for BMI ( 34021172) Malaria ( 31844061) Subcortical volume (MOSTest) ( 32665545) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		4 interacting genes: ABCE1 AR RNF10 TCF12	4 interacting genes: CEBPA EIF3J RNASE2 RNASEL
Entrez ID		6041	6059
HPRD ID		01590	03132
Ensembl ID		ENSG00000135828	ENSG00000164163
Uniprot IDs		Q05823	P61221
PDB IDs		1WDY 4G8K 4G8L 4OAU 4OAV	6ZME 6ZVJ 7A09
Enriched GO Terms of Interacting Partners?		Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Transcription Cis-regulatory Region Binding Prostate Induction Male Somatic Sex Determination Cytosolic Ribosome Negative Regulation Of Endoribonuclease Activity Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Androgen Binding Male Genitalia Morphogenesis POU Domain Binding Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Integrin Biosynthetic Process Negative Regulation Of Nuclease Activity Regulation Of Ribonuclease Activity Endoribonuclease Inhibitor Activity Cytoplasmic Translational Elongation Regulation Of Endoribonuclease Activity CTPase Activity CAT Tailing Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Gene Expression RNA Polymerase II General Transcription Initiation Factor Binding Regulation Of RNA Metabolic Process Cellular Response To Testosterone Stimulus Regulation Of Prostatic Bud Formation Positive Regulation Of Transcription By RNA Polymerase II Response To Gonadotropin-releasing Hormone Negative Regulation Of Schwann Cell Proliferation Regulation Of Nucleobase-containing Compound Metabolic Process Genitalia Morphogenesis Lateral Sprouting From An Epithelium Leydig Cell Differentiation Estrogen Response Element Binding Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Macromolecule Biosynthetic Process Prostate Gland Growth Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Epithelial Cell Differentiation Involved In Prostate Gland Development Regulation Of Cell Differentiation Translational Termination Protein Ufmylation HMG Box Domain Binding CAMP Response Element Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ribonucleoside Triphosphate Phosphatase Activity Male Sex Determination Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of RNA Biosynthetic Process	RNA Nuclease Activity Fat Cell Differentiation Nuclear Matrix RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Nuclease Activity Ribonuclease A Activity Endonuclease Activity CHOP-C/EBP Complex White Fat Cell Proliferation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Induction Of Bacterial Agglutination Response To Phenylpropanoid Defense Response To Virus Defense Response Fat Cell Proliferation RNA Metabolic Process Response To Lithium Ion Transcription By RNA Polymerase I Urea Metabolic Process Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion HMG Box Domain Binding Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Urea Cycle Interleukin-6-mediated Signaling Pathway Identical Protein Binding STAT Family Protein Binding Osteoblast Development Response To Virus Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Innate Immune Response In Mucosa
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