RNASEL

Description		ribonuclease L
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Nuclear Matrix
	Molecular Function	Nucleotide Binding RNA Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity RNA Nuclease Activity Protein Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity RRNA Binding Identical Protein Binding Ribonucleoprotein Complex Binding Metal Ion Binding
	Biological Process	RRNA Processing RNA Processing MRNA Processing Protein Phosphorylation Regulation Of Gene Expression Regulation Of MRNA Stability Negative Regulation Of Viral Genome Replication Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of D-glucose Import Regulation Of RNA Metabolic Process Defense Response To Virus
Pathways		OAS antiviral response Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Morning vs. evening chronotype ( 26835600) Multiple sclerosis ( 23412934)
Interacting Genes		4 interacting genes: ABCE1 AR RNF10 TCF12
Entrez ID		6041
HPRD ID		01590
Ensembl ID		ENSG00000135828
Uniprot IDs		Q05823
PDB IDs		1WDY 4G8K 4G8L 4OAU 4OAV
Enriched GO Terms of Interacting Partners?		Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Transcription Cis-regulatory Region Binding Prostate Induction Male Somatic Sex Determination Cytosolic Ribosome Negative Regulation Of Endoribonuclease Activity Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Androgen Binding Male Genitalia Morphogenesis POU Domain Binding Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Integrin Biosynthetic Process Negative Regulation Of Nuclease Activity Regulation Of Ribonuclease Activity Endoribonuclease Inhibitor Activity Cytoplasmic Translational Elongation Regulation Of Endoribonuclease Activity CTPase Activity CAT Tailing Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Gene Expression RNA Polymerase II General Transcription Initiation Factor Binding Regulation Of RNA Metabolic Process Cellular Response To Testosterone Stimulus Regulation Of Prostatic Bud Formation Positive Regulation Of Transcription By RNA Polymerase II Response To Gonadotropin-releasing Hormone Negative Regulation Of Schwann Cell Proliferation Regulation Of Nucleobase-containing Compound Metabolic Process Genitalia Morphogenesis Lateral Sprouting From An Epithelium Leydig Cell Differentiation Estrogen Response Element Binding Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Macromolecule Biosynthetic Process Prostate Gland Growth Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Epithelial Cell Differentiation Involved In Prostate Gland Development Regulation Of Cell Differentiation Translational Termination Protein Ufmylation HMG Box Domain Binding CAMP Response Element Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ribonucleoside Triphosphate Phosphatase Activity Male Sex Determination Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of RNA Biosynthetic Process
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