HNF1B and SOX17

Number of citations: 106 (PubMedID 35140242)
Data Source: BioGRID (pull down)

		HNF1B	SOX17
Name		HNF1 homeobox B	SRY-box transcription factor 17
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Promoter-specific Chromatin Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endodermal Cell Fate Specification Kidney Development Inner Cell Mass Cell Differentiation Liver Development Regulation Of Transcription By RNA Polymerase II Apoptotic Process Notch Signaling Pathway Endoderm Development Response To Glucose Anterior/posterior Pattern Specification Gene Expression Positive Regulation Of Gene Expression Insulin Secretion Regulation Of Wnt Signaling Pathway Hindbrain Development Pancreas Development Endocrine Pancreas Development Regulation Of Pronephros Size Pronephric Nephron Tubule Development Negative Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development Embryonic Digestive Tract Morphogenesis System Development Branching Morphogenesis Of An Epithelial Tube Pronephros Development Genitalia Development Epithelial Cell Proliferation Positive Regulation Of Transcription Initiation By RNA Polymerase II Epithelium Development Ureteric Bud Elongation Kidney Morphogenesis Hepatoblast Differentiation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Mesonephric Nephron Morphogenesis Regulation Of Branch Elongation Involved In Ureteric Bud Branching Mesonephric Tubule Development Nephric Duct Development Mesonephric Duct Development Nephric Duct Formation Mesonephric Duct Formation Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development	Angiogenesis Vasculogenesis Metanephros Development Endoderm Formation Endodermal Cell Fate Specification Inner Cell Mass Cellular Morphogenesis Heart Looping Cardiogenic Plate Morphogenesis Embryonic Heart Tube Morphogenesis Outflow Tract Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Spermatogenesis Gastrulation Endoderm Development Endodermal Cell Fate Determination Heart Development Tissue Development Gene Expression Positive Regulation Of Gene Expression Wnt Signaling Pathway Rostrocaudal Neural Tube Patterning Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Protein Destabilization Embryonic Heart Tube Development Endodermal Cell Differentiation Cell Migration Involved In Gastrulation Response To Alkaloid Regulation Of Cell Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Embryonic Organ Development Embryonic Foregut Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Stem Cell Differentiation Stem Cell Fate Specification Protein Stabilization Endocardium Formation Cardiac Cell Fate Determination Heart Formation Endocardial Cell Differentiation Common Bile Duct Development Gallbladder Development Endodermal Digestive Tract Morphogenesis Regulation Of Stem Cell Proliferation Ureter Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Endodermal Cell Differentiation Cellular Response To Leukemia Inhibitory Factor Regulation Of Stem Cell Division Regulation Of Cardiac Cell Fate Specification Positive Regulation Of Stem Cell Differentiation
Pathways		Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells Regulation of gene expression in early pancreatic precursor cells Nephron development Developmental Lineage of Pancreatic Acinar Cells Developmental Lineage of Pancreatic Ductal Cells Developmental Lineage of Multipotent Pancreatic Progenitor Cells	Deactivation of the beta-catenin transactivating complex Formation of definitive endoderm Specification of primordial germ cells Developmental Lineage of Multipotent Pancreatic Progenitor Cells
Diseases		Uromodulin-associated kidney diseases, including: Medullary cystic kidney disease 2; Familial juvenile hyperuremic nephropathy; Glomerulocystic kidney disease Maturity onset diabetes of the young (MODY) Type II diabetes mellitus	Vesicoureteral reflux
GWAS		Alanine aminotransferase levels ( 34315874 33547301 ) Aspartate aminotransferase levels ( 34315874 33547301 ) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027 ) Blood urea nitrogen levels ( 29403010 31152163 ) Body mass index ( 28892062 ) C-reactive protein levels ( 33339817 ) Cancer ( 27197191 ) Cancer (pleiotropy) ( 27197191 ) Endometrial cancer ( 21499250 27135401 27008869 30093612 ) Endometrial cancer (endometrioid histology) ( 30093612 ) Endometrial endometrioid carcinoma ( 27135401 ) Epithelial ovarian cancer ( 25581431 ) Frontotemporal dementia ( 26154020 ) Gallstone disease ( 30504769 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Medication use (drugs used in diabetes) ( 31015401 ) Neuritic plaque ( 25188341 ) Ovarian cancer ( 23535730 ) Pancreatic cancer ( 29422604 ) Pancreatic ductal adenocarcinoma ( 30541042 ) Prostate cancer ( 34012061 30410027 31562322 18264097 25939597 18264096 20676098 26443449 27262462 ) Prostate-specific antigen levels ( 30410027 28139693 ) Serum prostate-specific antigen levels ( 21160077 ) Testicular germ cell tumor ( 28604728 28604732 25877299 ) Type 2 diabetes ( 24509480 30054458 20581827 22885922 22961080 23945395 32499647 28869590 30718926 26818947 30297969 )	Apolipoprotein B levels ( 32203549 ) Cholesterol, total ( 24097068 ) Factor VIII levels ( 30586737 ) Intracranial aneurysm ( 20364137 33199917 18997786 ) LDL cholesterol ( 24097068 ) LDL cholesterol levels ( 28334899 30698716 32203549 ) LDL cholesterol levels in current drinkers ( 30698716 ) LDL cholesterol levels in HIV infection ( 33109212 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Lung cancer ( 28604730 ) Lung cancer in ever smokers ( 28604730 ) Pulmonary arterial hypertension ( 30527956 ) Total cholesterol levels ( 28334899 )
Interacting Genes		35 interacting genes: ATF1 BPIFA1 C10orf55 CREB1 CREBBP CRX H3C1 HNF1A KRTAP26-1 LHX4 MLLT10 OTUD3 OTX2 OXER1 PAX2 PAX6 PAX7 PAX8 POU6F2 PRDM1 SOX10 SOX15 SOX17 SOX2 SOX5 SOX6 SOX9 SP7 TBR1 TLX2 TLX3 UFSP1 USP54 VAC14 YY1	4 interacting genes: CTNNB1 HNF1B NFIC NFIX
Entrez ID		6928	64321
HPRD ID		08926	18085
Ensembl ID		ENSG00000275410	ENSG00000164736
Uniprot IDs		A0A087WZC2 A0A0C4DGS8 E0YMJ6 P35680 Q6FHW6	Q9H6I2
PDB IDs		2DA6 2H8R 5K9S	2YUL 4A3N
GO Terms Enriched among Interactors		DNA-binding Transcription Factor Activity Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Transcription Cis-regulatory Region Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sequence-specific Double-stranded DNA Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Animal Organ Development Regulation Of Nucleobase-containing Compound Metabolic Process Cell Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Neuron Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Cell Fate Specification Positive Regulation Of Biosynthetic Process Positive Regulation Of Stem Cell Differentiation Transcription Regulator Complex Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Cellular Developmental Process Cell Fate Commitment Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Metanephric Nephron Tubule Formation Sequence-specific DNA Binding Regulation Of Developmental Process Metanephric Tubule Formation Positive Regulation Of Mesenchymal Stem Cell Differentiation Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Lacrimal Gland Development Regulation Of Metabolic Process Gene Expression Regulation Of Multicellular Organismal Development Ureter Development Developmental Process Central Nervous System Development Regulation Of Stem Cell Differentiation Negative Regulation Of Mesenchymal Cell Apoptotic Process Regulation Of Mesenchymal Stem Cell Differentiation	Genitalia Development Nephric Duct Development Mesonephric Duct Development Positive Regulation Of Transcription By RNA Polymerase II Nephron Tubule Formation Epithelial Tube Morphogenesis Animal Organ Morphogenesis Branching Morphogenesis Of An Epithelial Tube Nephron Tubule Morphogenesis Positive Regulation Of RNA Biosynthetic Process Kidney Morphogenesis Kidney Development Morphogenesis Of A Branching Structure Morphogenesis Of A Branching Epithelium Positive Regulation Of DNA-templated Transcription Renal Tubule Morphogenesis Hindbrain Development Positive Regulation Of RNA Metabolic Process Reproductive Structure Development Nephron Tubule Development Embryonic Epithelial Tube Formation Tube Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process Renal Tubule Development Pancreas Development Epithelium Development Epithelial Tube Formation Gland Development Negative Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Tube Morphogenesis Regulation Of Transcription By RNA Polymerase II Transcription Coregulator Binding Detection Of Mechanical Stimulus Morphogenesis Of An Epithelium Positive Regulation Of Macromolecule Biosynthetic Process Mesonephric Tubule Development Mesonephric Epithelium Development Skin Development Positive Regulation Of Biosynthetic Process Tissue Morphogenesis DNA-templated Transcription Lateral Plasma Membrane Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Odontogenesis Of Dentin-containing Tooth Kidney Epithelium Development Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process