HNF1B and ALDOC

Data Source: HiPPIP (Novel)

		HNF1B	ALDOC
Name		HNF1 homeobox B	aldolase, fructose-bisphosphate C
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol	Extracellular Region Cytosol Cytoskeleton Secretory Granule Lumen Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Promoter-specific Chromatin Binding	Fructose-bisphosphate Aldolase Activity Protein Binding Cytoskeletal Protein Binding Lyase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endodermal Cell Fate Specification Kidney Development Inner Cell Mass Cell Differentiation Liver Development Regulation Of Transcription By RNA Polymerase II Apoptotic Process Notch Signaling Pathway Endoderm Development Response To Glucose Anterior/posterior Pattern Specification Gene Expression Positive Regulation Of Gene Expression Insulin Secretion Regulation Of Wnt Signaling Pathway Hindbrain Development Pancreas Development Endocrine Pancreas Development Regulation Of Pronephros Size Pronephric Nephron Tubule Development Negative Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development Embryonic Digestive Tract Morphogenesis System Development Branching Morphogenesis Of An Epithelial Tube Pronephros Development Genitalia Development Epithelial Cell Proliferation Positive Regulation Of Transcription Initiation By RNA Polymerase II Epithelium Development Ureteric Bud Elongation Kidney Morphogenesis Hepatoblast Differentiation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Mesonephric Nephron Morphogenesis Regulation Of Branch Elongation Involved In Ureteric Bud Branching Mesonephric Tubule Development Nephric Duct Development Mesonephric Duct Development Nephric Duct Formation Mesonephric Duct Formation Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development	Fructose Metabolic Process Gluconeogenesis Glycolytic Process Fructose 1,6-bisphosphate Metabolic Process Epithelial Cell Differentiation
Pathways		Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells Regulation of gene expression in early pancreatic precursor cells Nephron development Developmental Lineage of Pancreatic Acinar Cells Developmental Lineage of Pancreatic Ductal Cells Developmental Lineage of Multipotent Pancreatic Progenitor Cells	Neutrophil degranulation Glycolysis Gluconeogenesis
Diseases		Uromodulin-associated kidney diseases, including: Medullary cystic kidney disease 2; Familial juvenile hyperuremic nephropathy; Glomerulocystic kidney disease Maturity onset diabetes of the young (MODY) Type II diabetes mellitus	None
GWAS		Alanine aminotransferase levels ( 34315874 33547301 ) Aspartate aminotransferase levels ( 34315874 33547301 ) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027 ) Blood urea nitrogen levels ( 29403010 31152163 ) Body mass index ( 28892062 ) C-reactive protein levels ( 33339817 ) Cancer ( 27197191 ) Cancer (pleiotropy) ( 27197191 ) Endometrial cancer ( 21499250 27135401 27008869 30093612 ) Endometrial cancer (endometrioid histology) ( 30093612 ) Endometrial endometrioid carcinoma ( 27135401 ) Epithelial ovarian cancer ( 25581431 ) Frontotemporal dementia ( 26154020 ) Gallstone disease ( 30504769 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Medication use (drugs used in diabetes) ( 31015401 ) Neuritic plaque ( 25188341 ) Ovarian cancer ( 23535730 ) Pancreatic cancer ( 29422604 ) Pancreatic ductal adenocarcinoma ( 30541042 ) Prostate cancer ( 34012061 30410027 31562322 18264097 25939597 18264096 20676098 26443449 27262462 ) Prostate-specific antigen levels ( 30410027 28139693 ) Serum prostate-specific antigen levels ( 21160077 ) Testicular germ cell tumor ( 28604728 28604732 25877299 ) Type 2 diabetes ( 24509480 30054458 20581827 22885922 22961080 23945395 32499647 28869590 30718926 26818947 30297969 )	No GWAS studies recorded
Novel Interactors		5 novel interactors: ALDOC ASGR2 CDK5R1 ERC2 PARD3	1 novel interactors: HNF1B
Interacting Genes		35 interacting genes: ATF1 BPIFA1 C10orf55 CREB1 CREBBP CRX H3C1 HNF1A KRTAP26-1 LHX4 MLLT10 OTUD3 OTX2 OXER1 PAX2 PAX6 PAX7 PAX8 POU6F2 PRDM1 SOX10 SOX15 SOX17 SOX2 SOX5 SOX6 SOX9 SP7 TBR1 TLX2 TLX3 UFSP1 USP54 VAC14 YY1	9 interacting genes: ANKS1A ATP6V1E1 CFTR ERBB2 FMR1 LNX1 MAP2K3 PLD2 SQLE
Entrez ID		6928	230
HPRD ID		08926	02386
Ensembl ID		ENSG00000275410	ENSG00000109107
Uniprot IDs		A0A087WZC2 A0A0C4DGS8 E0YMJ6 P35680 Q6FHW6	A0A024QZ64 P09972
PDB IDs		2DA6 2H8R 5K9S	1XFB
GO Terms Enriched among Interactors		DNA-binding Transcription Factor Activity Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Transcription Cis-regulatory Region Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sequence-specific Double-stranded DNA Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Animal Organ Development Regulation Of Nucleobase-containing Compound Metabolic Process Cell Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Neuron Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Cell Fate Specification Positive Regulation Of Biosynthetic Process Positive Regulation Of Stem Cell Differentiation Transcription Regulator Complex Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Cellular Developmental Process Cell Fate Commitment Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Metanephric Nephron Tubule Formation Sequence-specific DNA Binding Regulation Of Developmental Process Metanephric Tubule Formation Positive Regulation Of Mesenchymal Stem Cell Differentiation Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Lacrimal Gland Development Regulation Of Metabolic Process Gene Expression Regulation Of Multicellular Organismal Development Ureter Development Developmental Process Central Nervous System Development Regulation Of Stem Cell Differentiation Negative Regulation Of Mesenchymal Cell Apoptotic Process Regulation Of Mesenchymal Stem Cell Differentiation	Apical Plasma Membrane Proton-transporting Two-sector ATPase Complex, Catalytic Domain Cholesterol Biosynthetic Process Regulation Of Transmembrane Transporter Activity Developmental Maturation Positive Regulation Of Anion Channel Activity Steroid Biosynthetic Process Sterol Biosynthetic Process Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding PDZ Domain Binding Regulation Of Monoatomic Ion Transmembrane Transporter Activity ERBB3:ERBB2 Complex Dendritic Filopodium Histone H3 Reader Activity Positive Regulation Of Intracellular Transport Of Viral Material Cellular Response To Sorbitol Squalene Monooxygenase Activity Mesonephric Duct Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Mesonephric Nephron Morphogenesis Ureteric Bud Elongation Pronephric Nephron Tubule Development Hepatoblast Differentiation Regulation Of Pronephros Size Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Positive Regulation Of Monoatomic Anion Transport RNA Polymerase I Core Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Negative Regulation Of Long-term Synaptic Depression Growth Cone Filopodium Response To Biphenyl Regulation Of Branch Elongation Involved In Ureteric Bud Branching Mesonephric Duct Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Proton-transporting Two-sector ATPase Complex Sterol Metabolic Process Cholesterol Metabolic Process Positive Regulation Of Tooth Mineralization Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Lipid Biosynthetic Process Cell Maturation Regulation Of Vesicle-mediated Transport Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Negative Regulation Of Immature T Cell Proliferation ErbB-3 Class Receptor Binding Presynaptic Membrane