HNF1B and PARD3

		HNF1B	PARD3
Description		HNF1 homeobox B	par-3 family cell polarity regulator
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Cell Cortex Endomembrane System Membrane Apical Plasma Membrane Cell Junction Internode Region Of Axon Apical Junction Complex Tight Junction Anchoring Junction PAR Polarity Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Promoter-specific Chromatin Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Lipid Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endodermal Cell Fate Specification Kidney Development Inner Cell Mass Cell Differentiation Liver Development Regulation Of Transcription By RNA Polymerase II Apoptotic Process Notch Signaling Pathway Endoderm Development Response To Glucose Anterior/posterior Pattern Specification Gene Expression Positive Regulation Of Gene Expression Insulin Secretion Regulation Of Wnt Signaling Pathway Hindbrain Development Pancreas Development Endocrine Pancreas Development Regulation Of Pronephros Size Pronephric Nephron Tubule Development Negative Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development Embryonic Digestive Tract Morphogenesis System Development Branching Morphogenesis Of An Epithelial Tube Pronephros Development Genitalia Development Epithelial Cell Proliferation Positive Regulation Of Transcription Initiation By RNA Polymerase II Epithelium Development Ureteric Bud Elongation Kidney Morphogenesis Hepatoblast Differentiation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Mesonephric Nephron Morphogenesis Regulation Of Branch Elongation Involved In Ureteric Bud Branching Mesonephric Tubule Development Nephric Duct Development Mesonephric Duct Development Nephric Duct Formation Mesonephric Duct Formation Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development	Microtubule Cytoskeleton Organization Protein Targeting To Membrane Cell Adhesion Establishment Or Maintenance Of Cell Polarity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Axonogenesis Intracellular Protein Localization Asymmetric Cell Division Negative Regulation Of Peptidyl-threonine Phosphorylation Myelination In Peripheral Nervous System Establishment Of Cell Polarity Cell Differentiation Positive Regulation Of Myelination Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Division Establishment Of Centrosome Localization Protein-containing Complex Assembly Bicellular Tight Junction Assembly Establishment Of Epithelial Cell Polarity
Pathways		Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells Regulation of gene expression in early pancreatic precursor cells Nephron development Developmental Lineage of Pancreatic Acinar Cells Developmental Lineage of Pancreatic Ductal Cells Developmental Lineage of Multipotent Pancreatic Progenitor Cells	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions
Drugs
Diseases		Uromodulin-associated kidney diseases, including: Medullary cystic kidney disease 2; Familial juvenile hyperuremic nephropathy; Glomerulocystic kidney disease Maturity onset diabetes of the young (MODY) Type II diabetes mellitus
GWAS		Alanine aminotransferase levels ( 34315874 33547301) Aspartate aminotransferase levels ( 34315874 33547301) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Blood urea nitrogen levels ( 29403010 31152163) Body mass index ( 28892062) C-reactive protein levels ( 33339817) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Endometrial cancer ( 21499250 27135401 27008869 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Endometrial endometrioid carcinoma ( 27135401) Epithelial ovarian cancer ( 25581431) Frontotemporal dementia ( 26154020) Gallstone disease ( 30504769) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Medication use (drugs used in diabetes) ( 31015401) Neuritic plaque ( 25188341) Ovarian cancer ( 23535730) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042) Prostate cancer ( 34012061 30410027 31562322 18264097 25939597 18264096 20676098 26443449 27262462) Prostate-specific antigen levels ( 30410027 28139693) Serum prostate-specific antigen levels ( 21160077) Testicular germ cell tumor ( 28604728 28604732 25877299) Type 2 diabetes ( 24509480 30054458 20581827 22885922 22961080 23945395 32499647 28869590 30718926 26818947 30297969)	Acute lymphoblastic leukemia (childhood) ( 19684603) Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Corneal astigmatism ( 30306274) Emphysema-related traits ( 20709820) Estimated glomerular filtration rate ( 31015462) Gut microbiota relative abundance (Sutterella) ( 33208821) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 28552196) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung function (FEV1/FVC) ( 30804560) Major depressive disorder ( 21621269) Parkinson's disease progression (composite) ( 33111402) Schizophrenia ( 21682944)
Interacting Genes		35 interacting genes: ATF1 BPIFA1 C10orf55 CREB1 CREBBP CRX H3C1 HNF1A KRTAP26-1 LHX4 MLLT10 OTUD3 OTX2 OXER1 PAX2 PAX6 PAX7 PAX8 POU6F2 PRDM1 SOX10 SOX15 SOX17 SOX2 SOX5 SOX6 SOX9 SP7 TBR1 TLX2 TLX3 UFSP1 USP54 VAC14 YY1	31 interacting genes: ACE2 CDC42 DYNLL1 F11R INSC LIMK2 NECTIN1 NECTIN3 PARD6A PARD6B PARD6G PATJ PLCB1 PLCB3 PNMA1 PRKCG PRKCI SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 STK11 TIAM1 TIAM2 TTN UBC YWHAB YWHAG YWHAH YWHAZ
Entrez ID		6928	56288
HPRD ID		08926	05994
Ensembl ID		ENSG00000275410	ENSG00000148498
Uniprot IDs		A0A087WZC2 A0A0C4DGS8 E0YMJ6 P35680 Q6FHW6	Q8TEW0
PDB IDs		2DA6 2H8R 5K9S	2KOM
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Activity Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Transcription Cis-regulatory Region Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sequence-specific Double-stranded DNA Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Animal Organ Development Regulation Of Nucleobase-containing Compound Metabolic Process Cell Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Neuron Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Cell Fate Specification Positive Regulation Of Biosynthetic Process Positive Regulation Of Stem Cell Differentiation Transcription Regulator Complex Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Cellular Developmental Process Cell Fate Commitment Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Metanephric Nephron Tubule Formation Sequence-specific DNA Binding Regulation Of Developmental Process Metanephric Tubule Formation Positive Regulation Of Mesenchymal Stem Cell Differentiation Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Lacrimal Gland Development Regulation Of Metabolic Process Gene Expression Regulation Of Multicellular Organismal Development Ureter Development Developmental Process Central Nervous System Development Regulation Of Stem Cell Differentiation Negative Regulation Of Mesenchymal Cell Apoptotic Process Regulation Of Mesenchymal Stem Cell Differentiation	Heteromeric SMAD Protein Complex Intracellular Signal Transduction I-SMAD Binding Tight Junction PAR Polarity Complex Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity SMAD Protein Complex Establishment Or Maintenance Of Apical/basal Cell Polarity SMAD Protein Signal Transduction Cell-cell Junction Organization Cytosol Protein-containing Complex Establishment Or Maintenance Of Cell Polarity Mesonephric Tubule Development Mesonephric Epithelium Development Identical Protein Binding Cytoplasm Regulation Of Cellular Component Organization Bicellular Tight Junction Tube Development Kidney Epithelium Development Positive Regulation Of Cell Differentiation Endoderm Development Regulation Of Protein Localization Anchoring Junction Ureteric Bud Development Co-SMAD Binding Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Localization Primary MiRNA Processing Golgi Localization Cell Junction Organization Intracellular Protein Localization Extracellular Exosome Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Transport Homomeric SMAD Protein Complex Cardiac Conduction System Development Regulation Of Cell Differentiation Intracellular Signaling Cassette Regulation Of Signaling Regulation Of Cell Communication Regulation Of Transport Signal Transduction Embryonic Pattern Specification Epithelium Development Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Cellular Localization Transcription Regulator Complex Response To Monosaccharide
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