ELOB and ACSM5

		ELOB	ACSM5
Description		elongin B	acyl-CoA synthetase medium chain family member 5
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol VCB Complex Cul2-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Elongin Complex	Mitochondrion Mitochondrial Matrix
	Molecular Function	Transcription Corepressor Binding Protein Binding Ubiquitin Protein Ligase Binding	Nucleotide Binding Fatty-acyl-CoA Synthase Activity ATP Binding GTP Binding Fatty Acid Ligase Activity CoA-ligase Activity Ligase Activity Acid-thiol Ligase Activity Medium-chain Fatty Acid-CoA Ligase Activity Metal Ion Binding
	Biological Process	Transcription Initiation At RNA Polymerase II Promoter Transcription Elongation By RNA Polymerase II Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Assembly Target-directed MiRNA Degradation	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Acyl-CoA Metabolic Process
Pathways		Formation of RNA Pol II elongation complex Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Vif-mediated degradation of APOBEC3G RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation Neddylation Regulation of expression of SLITs and ROBOs Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation Evasion by RSV of host interferon responses Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Conjugation of salicylate with glycine Aspirin ADME
Drugs
Diseases
GWAS			Chronic kidney disease ( 20383146)
Interacting Genes		23 interacting genes: ASB11 ASB2 ASB8 BRD4 CEBPA CEBPE ELOA ELOA2 ELOA3P ELOC EPOR GHR GPS1 LRRC41 MRPL53 PRAME RACK1 RBX1 SOCS1 SOCS3 SOCS6 VHL ZYG11B	1 interacting genes: EP300
Entrez ID		6923	54988
HPRD ID		02874	08627
Ensembl ID		ENSG00000103363	ENSG00000183549
Uniprot IDs		A0A384MDL3 Q15370	Q6NUN0
PDB IDs		1LM8 1LQB 1VCB 2C9W 2IZV 2JZ3 2MA9 3DCG 3ZKJ 3ZNG 3ZRC 3ZRF 3ZTC 3ZTD 3ZUN 4AJY 4AWJ 4B95 4B9K 4BKS 4BKT 4N9F 4W9C 4W9D 4W9E 4W9F 4W9G 4W9H 4W9I 4W9J 4W9K 4W9L 4WQO 5BO4 5LLI 5N4W 5NVV 5NVW 5NVX 5NVY 5NVZ 5NW0 5NW1 5NW2 5T35 6BVB 6C5X 6FMI 6FMJ 6FMK 6GFX 6GFY 6GFZ 6GMN 6GMQ 6GMR 6GMX 6HAX 6HAY 6HR2 6I4X 6I5J 6I5N 6I7Q 6I7R 6P59 6R6H 6R7F 6R7H 6R7I 6R7N 6SIS 6V9H 6ZHC 7CJB 7JTO 7JTP 7KHH 7M6T 7PI4 7PLO 7Q2J 7S4E 7UPN 7Z6L 7Z76 7Z77 7ZLM 7ZLN 7ZLO 7ZLP 7ZLR 7ZLS 7ZNT 8BB2 8BB3 8BB4 8BB5 8BDI 8BDJ 8BDL 8BDM 8BDN 8BDO 8BDS 8BDT 8BDX 8BEB 8C13 8CQE 8CQK 8CQL 8CX0 8CX1 8CX2 8EBN 8EI3 8EWV 8FVI 8FVJ 8FY0 8FY1 8FY2 8G1P 8G1Q 8IJ1 8JAL 8JAQ 8JAR 8JAS 8JAU 8JAV 8JE1 8JE2 8OEV 8OEW 8OF0 8OKX 8OL1 8P0F 8PC2 8PQL 8Q7R 8QJR 8QJS 8QU8 8QVU 8QW6 8QW7 8R5H 8RWZ 8RX0 8SH2 8SZK 8VL9 8VLB 8WDK 8WQA 8WQB 8WQC 8WQE 8WQF 8WQG 8WQH 8Y1U 8YMB 8ZV8 8ZVJ 9BJU 9BOL 9D1I 9D1Y 9D1Z 9D8P 9EQJ 9EQM 9IPW
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Metabolic Process Elongin Complex Proteolysis Involved In Protein Catabolic Process Cul2-RING Ubiquitin Ligase Complex Protein Modification Process Macromolecule Metabolic Process Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Proteasomal Protein Catabolic Process Cul5-RING Ubiquitin Ligase Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Receptor Signaling Pathway Via JAK-STAT VCB Complex Cell Surface Receptor Signaling Pathway Via STAT Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Intracellular Signal Transduction Macrophage Differentiation Transcription Elongation By RNA Polymerase II Protein Tyrosine Kinase Inhibitor Activity Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Cytokine-mediated Signaling Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Catabolic Process DNA-templated Transcription Elongation Negative Regulation Of Signal Transduction GTPase Inhibitor Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Insulin Receptor Signaling Pathway Interleukin-6-mediated Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Centrosome Duplication	Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Thigmotaxis Peptide Lactyltransferase (CoA-dependent) Activity VCB Complex Nucleobase-containing Compound Catabolic Process Negative Regulation Of Protein Oligomerization Target-directed MiRNA Degradation Elongin Complex L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Positive Regulation Of TORC2 Signaling Positive Regulation Of T-helper 17 Cell Lineage Commitment Regulation Of Tubulin Deacetylation Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Pre-mRNA Intronic Binding Positive Regulation Of T-helper 17 Cell Differentiation Regulation Of Protein Deacetylation Cellular Response To L-leucine N-terminal Protein Amino Acid Acetylation Internal Protein Amino Acid Acetylation Peptidyl-lysine Acetylation Regulation Of TORC2 Signaling Positive Regulation Of Cell Fate Commitment T-helper 17 Cell Lineage Commitment STAT Family Protein Binding Histone H4 Acetyltransferase Activity MiRNA Catabolic Process TORC2 Signaling Regulation Of Cellular Response To Heat Response To L-leucine Negative Regulation Of MiRNA-mediated Gene Silencing Cul5-RING Ubiquitin Ligase Complex Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Host-mediated Activation Of Viral Transcription
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