CEBPE and IL7

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		CEBPE	IL7
Name		CCAAT enhancer binding protein epsilon	interleukin 7
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Plasma Membrane RNA Polymerase II Transcription Regulator Complex	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein-containing Complex Binding Sequence-specific Double-stranded DNA Binding	Cytokine Activity Cytokine Receptor Binding Interleukin-7 Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Phagocytosis Defense Response Positive Regulation Of Gene Expression Myeloid Cell Differentiation Macrophage Differentiation Granulocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide Integrated Stress Response Signaling	Positive Regulation Of Cytokine-mediated Signaling Pathway T Cell Lineage Commitment Immune Response Humoral Immune Response Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Regulation Of Gene Expression Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Cellular Homeostasis Positive Regulation Of B Cell Proliferation Positive Regulation Of Chemokine Production Organ Growth Interleukin-7-mediated Signaling Pathway B Cell Proliferation Negative Regulation Of Apoptotic Process Bone Resorption Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Organ Growth Homeostasis Of Number Of Cells Within A Tissue Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Transcriptional regulation of granulopoiesis	Interleukin-7 signaling Interleukin-7 signaling
Diseases		Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome	None
GWAS		Acute lymphoblastic leukemia (B-cell precursor) ( 23996088 ) Acute lymphoblastic leukemia (childhood) ( 22076464 23512250 29348612 19684604 ) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299 ) B-cell acute lymphoblastic leukaemia ( 31767839 ) Basophil count ( 32888494 ) Basophil percentage of granulocytes ( 27863252 ) Basophil percentage of white cells ( 32888494 27863252 ) Eosinophil count ( 32888494 27863252 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 32888494 27863252 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Monocyte count ( 27863252 32888494 29403010 ) Monocyte percentage of white cells ( 27863252 32888494 ) Neutrophil percentage of granulocytes ( 27863252 ) Neutrophil percentage of white cells ( 32888494 27863252 ) Sum eosinophil basophil counts ( 27863252 ) White blood cell count (basophil) ( 29403010 28158719 27863252 )	Blood protein levels ( 30072576 ) Lymphocyte count ( 27863252 32888494 ) Lymphocyte percentage of white cells ( 27863252 32888494 ) Monocyte percentage of white cells ( 32888494 ) Multiple sclerosis ( 21833088 ) Neutrophil percentage of white cells ( 27863252 32888494 ) Suicide in bipolar disorder ( 25917933 )
Novel Interactors		None recorded	1 novel interactors: LYN
Interacting Genes		45 interacting genes: ALX4 ATF3 ATF4 ATF5 BATF BATF2 BATF3 CCT7 CEBPA CEBPD CEBPG COPS3 CSNK1A1L DDIT3 DENND4A E2F1 EDA2R ELOB FOS FOSL1 GATA1 GPR22 GTF2A1L IL7 JUN KDM2B LDOC1 MED16 MLLT6 MYB NELFB PIAS1 POU2F1 PSAT1 RB1 SIPA1L1 SPI1 STAT6 TAF5L TBX2 TRIB1 UBE2I ZFP2 ZMYM2 ZNF384	5 interacting genes: APP CEBPE FBXO7 IL2RG IL7R
Entrez ID		1053	3574
HPRD ID		02852	00892
Ensembl ID		ENSG00000092067	ENSG00000104432
Uniprot IDs		Q15744	A0A0A0MTG5 A8K673 P13232 Q5FBX5
PDB IDs		3T92	3DI2 3DI3
GO Terms Enriched among Interactors		RNA Polymerase II Transcription Regulator Complex Integrated Stress Response Signaling DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Transcription Regulator Complex Positive Regulation Of Biosynthetic Process Transcription Cis-regulatory Region Binding Nucleus Positive Regulation Of Macromolecule Metabolic Process Myeloid Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Sequence-specific DNA Binding Positive Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Negative Regulation Of Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Metabolic Process Myeloid Leukocyte Differentiation Positive Regulation Of MiRNA Transcription Mononuclear Cell Differentiation DNA-templated Transcription Negative Regulation Of Metabolic Process Positive Regulation Of MiRNA Metabolic Process Nucleoplasm DNA-binding Transcription Factor Binding	Mononuclear Cell Differentiation Leukocyte Differentiation Interleukin-7 Receptor Activity Leukocyte Activation Regulation Of Cell Activation Cell Activation Signaling Receptor Activator Activity Interleukin-7-mediated Signaling Pathway Positive Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Cell Activation Regulation Of Hemopoiesis Lymphocyte Activation Regulation Of Lymphocyte Activation Hemopoiesis Cellular Developmental Process Regulation Of T Cell Differentiation In Thymus B Cell Activation Regulation Of Cell Differentiation Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Immune System Process Ephrin Receptor Binding Granulocyte Differentiation Regulation Of Lymphocyte Differentiation B Cell Homeostasis Regulation Of Monocyte Chemotaxis Lymphocyte Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of T Cell Activation Regulation Of Cell Development Immune System Process Positive Regulation Of Leukocyte Cell-cell Adhesion B Cell Proliferation Positive Regulation Of Cell Differentiation T Cell Differentiation In Thymus Cytokine Receptor Activity Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation External Side Of Plasma Membrane Positive Regulation Of Immune System Process Regulation Of Lymphocyte Apoptotic Process Lymphocyte Homeostasis Glial Cell Development Regulation Of Leukocyte Cell-cell Adhesion Immune Effector Process Regulation Of T Cell Activation Cell Differentiation Cytokine-mediated Signaling Pathway Amyloid-beta Complex Immune Response