CEBPE and GPR22

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		CEBPE	GPR22
Name		CCAAT enhancer binding protein epsilon	G protein-coupled receptor 22
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Plasma Membrane RNA Polymerase II Transcription Regulator Complex	Plasma Membrane Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein-containing Complex Binding Sequence-specific Double-stranded DNA Binding	G Protein-coupled Receptor Activity
	Biological Process	DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Phagocytosis Defense Response Positive Regulation Of Gene Expression Myeloid Cell Differentiation Macrophage Differentiation Granulocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide Integrated Stress Response Signaling	Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell Projection Organization Cellular Response To Hormone Stimulus
Pathways		Transcriptional regulation of granulopoiesis	None
Diseases		Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome	None
GWAS		Acute lymphoblastic leukemia (B-cell precursor) ( 23996088 ) Acute lymphoblastic leukemia (childhood) ( 22076464 23512250 29348612 19684604 ) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299 ) B-cell acute lymphoblastic leukaemia ( 31767839 ) Basophil count ( 32888494 ) Basophil percentage of granulocytes ( 27863252 ) Basophil percentage of white cells ( 32888494 27863252 ) Eosinophil count ( 32888494 27863252 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 32888494 27863252 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Monocyte count ( 27863252 32888494 29403010 ) Monocyte percentage of white cells ( 27863252 32888494 ) Neutrophil percentage of granulocytes ( 27863252 ) Neutrophil percentage of white cells ( 32888494 27863252 ) Sum eosinophil basophil counts ( 27863252 ) White blood cell count (basophil) ( 29403010 28158719 27863252 )	Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Interacting Genes		45 interacting genes: ALX4 ATF3 ATF4 ATF5 BATF BATF2 BATF3 CCT7 CEBPA CEBPD CEBPG COPS3 CSNK1A1L DDIT3 DENND4A E2F1 EDA2R ELOB FOS FOSL1 GATA1 GPR22 GTF2A1L IL7 JUN KDM2B LDOC1 MED16 MLLT6 MYB NELFB PIAS1 POU2F1 PSAT1 RB1 SIPA1L1 SPI1 STAT6 TAF5L TBX2 TRIB1 UBE2I ZFP2 ZMYM2 ZNF384	3 interacting genes: CEBPE NFATC4 TFAP2C
Entrez ID		1053	2845
HPRD ID		02852	03552
Ensembl ID		ENSG00000092067	ENSG00000172209
Uniprot IDs		Q15744	B3KV13 Q3KNS9 Q99680
PDB IDs		3T92	Not available
GO Terms Enriched among Interactors		RNA Polymerase II Transcription Regulator Complex Integrated Stress Response Signaling DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Transcription Regulator Complex Positive Regulation Of Biosynthetic Process Transcription Cis-regulatory Region Binding Nucleus Positive Regulation Of Macromolecule Metabolic Process Myeloid Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Sequence-specific DNA Binding Positive Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Negative Regulation Of Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Metabolic Process Myeloid Leukocyte Differentiation Positive Regulation Of MiRNA Transcription Mononuclear Cell Differentiation DNA-templated Transcription Negative Regulation Of Metabolic Process Positive Regulation Of MiRNA Metabolic Process Nucleoplasm DNA-binding Transcription Factor Binding	DNA-templated Transcription Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity Nucleobase-containing Compound Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Dichotomous Subdivision Of Terminal Units Involved In Mammary Gland Duct Morphogenesis RNA Metabolic Process Negative Regulation Of Synapse Maturation Morula Formation Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Brain-derived Neurotrophic Factor Receptor Signaling Pathway Transcription By RNA Polymerase II DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Germ-line Stem Cell Population Maintenance Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Morphogenesis Of An Epithelium Inner Cell Mass Cell Differentiation Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Negative Regulation Of Dendrite Morphogenesis Vascular Associated Smooth Muscle Cell Differentiation Sebaceous Gland Development Forebrain Neuron Fate Commitment Tissue Morphogenesis DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Keratinocyte Development Vascular Associated Smooth Muscle Cell Development Cell Differentiation Negative Regulation Of Synapse Organization Cellular Response To Lithium Ion Synapse Maturation Mammary Gland Epithelial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Response To Lithium Ion Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Trophectodermal Cell Differentiation Calcineurin-NFAT Signaling Cascade Positive Regulation Of Biosynthetic Process Cellular Developmental Process Smooth Muscle Cell Differentiation Negative Regulation Of MiRNA Transcription Regulation Of Synapse Maturation