TBCD and POLR2I

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		TBCD	POLR2I
Description		tubulin folding cofactor D	RNA polymerase II subunit I
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytoskeleton Microtubule Plasma Membrane Adherens Junction Bicellular Tight Junction Membrane Lateral Plasma Membrane Anchoring Junction	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm RNA Polymerase II, Core Complex Nucleolus
	Molecular Function	GTPase Activator Activity Protein Binding Beta-tubulin Binding Protein-folding Chaperone Binding	Nucleic Acid Binding DNA-directed RNA Polymerase Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Protein Folding Tubulin Complex Assembly Post-chaperonin Tubulin Folding Pathway Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Microtubule Polymerization Adherens Junction Assembly Cell Morphogenesis Involved In Neuron Differentiation Bicellular Tight Junction Assembly	Maintenance Of Transcriptional Fidelity During Transcription Elongation By RNA Polymerase II Transcription-coupled Nucleotide-excision Repair DNA-templated Transcription Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter
Pathways		Post-chaperonin tubulin folding pathway	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Bone mineral accretion in asthma (oral corticosteroid dose interaction) ( 26025128) Mean platelet volume ( 32888494) Moderate-to-late spontaneous preterm birth ( 31194736) Response to cognitive-behavioural therapy in anxiety and major depressive disorders ( 31123309)
Interacting Genes		14 interacting genes: ACD APP ARL2 COMMD4 DEXI MTDH MTNR1B POLR2I POT1 SMAD9 TBCE TERF1 TUBB XRCC6	2 interacting genes: POLR2H TBCD
Entrez ID		6904	5438
HPRD ID		05227	15944
Ensembl ID		ENSG00000141556	ENSG00000105258
Uniprot IDs		A0A804HI02 A0A804HIN6 A0A804HJ32 A0A804HJU6 A0A804HLI2 Q9BTW9	P36954
PDB IDs			5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L 6XRE 7LBM 9EHZ 9EI1 9EI3 9EI4
Enriched GO Terms of Interacting Partners?		Nuclear Telomere Cap Complex Telomeric DNA Binding Shelterin Complex Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Telomere Maintenance RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Organization Negative Regulation Of Telomere Maintenance Telomere Assembly Regulation Of Telomere Maintenance Via Telomerase Chromosome, Telomeric Region Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Double-stranded Telomeric DNA Binding Telomeric D-loop Disassembly Positive Regulation Of Telomere Maintenance G-rich Strand Telomeric DNA Binding Nuclear Envelope Lumen Telomeric Loop Disassembly Negative Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process DNA Biosynthetic Process Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Chromosome Organization Negative Regulation Of DNA Metabolic Process DNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Establishment Of Protein Localization Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleolus Positive Regulation Of Organelle Organization Maintenance Of Transcriptional Fidelity During Transcription Elongation By RNA Polymerase II Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly	RNA Polymerase III Complex RNA Polymerase I Complex RNA Polymerase II, Core Complex Adherens Junction Assembly Negative Regulation Of Microtubule Polymerization Post-chaperonin Tubulin Folding Pathway Tubulin Complex Assembly Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Retinoic Acid-responsive Element Binding Regulation Of Retinoic Acid Receptor Signaling Pathway
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